Frailty Is Associated with Oxidative Stress in Older Patients with Type 2 Diabetes

Aging has increased the prevalence of frailty, and type 2 diabetes (T2D) has also increased in prevalence. Diabetes and oxidative stress (OS) have been shown to be related to frailty. However, the exact mechanism by which it occurs is not fully known. Our aim was to analyze body composition in commu...

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Autores principales:	Blanca Alabadi, Miguel Civera, Adrián De la Rosa, Sergio Martinez-Hervas, Mari Carmen Gomez-Cabrera, José T. Real
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	frailty diabetes aging body composition oxidative stress Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/a9ff0e3eb8a340209965711e9dce3562
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id	oai:doaj.org-article:a9ff0e3eb8a340209965711e9dce3562
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spelling	oai:doaj.org-article:a9ff0e3eb8a340209965711e9dce35622021-11-25T18:35:48ZFrailty Is Associated with Oxidative Stress in Older Patients with Type 2 Diabetes10.3390/nu131139832072-6643https://doaj.org/article/a9ff0e3eb8a340209965711e9dce35622021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6643/13/11/3983https://doaj.org/toc/2072-6643Aging has increased the prevalence of frailty, and type 2 diabetes (T2D) has also increased in prevalence. Diabetes and oxidative stress (OS) have been shown to be related to frailty. However, the exact mechanism by which it occurs is not fully known. Our aim was to analyze body composition in community-dwelling older diabetic people treated in our center and to evaluate the possible relation between OS, frailty, and body composition. We included 100 adults older than 65 years with T2D. We found that 15% were frail and 57% were prefrail. The patients included in the nonrobust group showed increased levels of OS. Our study shows that the presence of T2D in the geriatric population is associated with a high prevalence of frailty and high OS levels, conditions that cause greater morbidity and mortality and that highlight the importance of the diagnosis of frailty in this population.Blanca AlabadiMiguel CiveraAdrián De la RosaSergio Martinez-HervasMari Carmen Gomez-CabreraJosé T. RealMDPI AGarticlefrailtydiabetesagingbody compositionoxidative stressNutrition. Foods and food supplyTX341-641ENNutrients, Vol 13, Iss 3983, p 3983 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	frailty diabetes aging body composition oxidative stress Nutrition. Foods and food supply TX341-641
spellingShingle	frailty diabetes aging body composition oxidative stress Nutrition. Foods and food supply TX341-641 Blanca Alabadi Miguel Civera Adrián De la Rosa Sergio Martinez-Hervas Mari Carmen Gomez-Cabrera José T. Real Frailty Is Associated with Oxidative Stress in Older Patients with Type 2 Diabetes
description	Aging has increased the prevalence of frailty, and type 2 diabetes (T2D) has also increased in prevalence. Diabetes and oxidative stress (OS) have been shown to be related to frailty. However, the exact mechanism by which it occurs is not fully known. Our aim was to analyze body composition in community-dwelling older diabetic people treated in our center and to evaluate the possible relation between OS, frailty, and body composition. We included 100 adults older than 65 years with T2D. We found that 15% were frail and 57% were prefrail. The patients included in the nonrobust group showed increased levels of OS. Our study shows that the presence of T2D in the geriatric population is associated with a high prevalence of frailty and high OS levels, conditions that cause greater morbidity and mortality and that highlight the importance of the diagnosis of frailty in this population.
format	article
author	Blanca Alabadi Miguel Civera Adrián De la Rosa Sergio Martinez-Hervas Mari Carmen Gomez-Cabrera José T. Real
author_facet	Blanca Alabadi Miguel Civera Adrián De la Rosa Sergio Martinez-Hervas Mari Carmen Gomez-Cabrera José T. Real
author_sort	Blanca Alabadi
title	Frailty Is Associated with Oxidative Stress in Older Patients with Type 2 Diabetes
title_short	Frailty Is Associated with Oxidative Stress in Older Patients with Type 2 Diabetes
title_full	Frailty Is Associated with Oxidative Stress in Older Patients with Type 2 Diabetes
title_fullStr	Frailty Is Associated with Oxidative Stress in Older Patients with Type 2 Diabetes
title_full_unstemmed	Frailty Is Associated with Oxidative Stress in Older Patients with Type 2 Diabetes
title_sort	frailty is associated with oxidative stress in older patients with type 2 diabetes
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/a9ff0e3eb8a340209965711e9dce3562
work_keys_str_mv	AT blancaalabadi frailtyisassociatedwithoxidativestressinolderpatientswithtype2diabetes AT miguelcivera frailtyisassociatedwithoxidativestressinolderpatientswithtype2diabetes AT adriandelarosa frailtyisassociatedwithoxidativestressinolderpatientswithtype2diabetes AT sergiomartinezhervas frailtyisassociatedwithoxidativestressinolderpatientswithtype2diabetes AT maricarmengomezcabrera frailtyisassociatedwithoxidativestressinolderpatientswithtype2diabetes AT josetreal frailtyisassociatedwithoxidativestressinolderpatientswithtype2diabetes
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Frailty Is Associated with Oxidative Stress in Older Patients with Type 2 Diabetes

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