Are Dilated Fundus Examinations Needed for OCT-Guided Retreatment of Exudative Age-Related Macular Degeneration? A Prospective, Randomized, Pilot Study

Sharon D Solomon,1 Victoria Kyerematen,2 Madiha Qutab,3 Adam S Wenick,1 Jiangxia Wang,4 Barbara S Hawkins1,4 1Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD, USA; 2Bloomfield Court Hospital, National Health Services, London, UK; 3Department of Neurology, John...

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Autores principales:	Solomon SD, Kyerematen V, Qutab M, Wenick AS, Wang J, Hawkins BS
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	neovascular age-related macular degeneration anti-vegf injection time in clinic Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/a9ff6d23695247d6bddab7d9ce49adde
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spelling	oai:doaj.org-article:a9ff6d23695247d6bddab7d9ce49adde2021-12-02T17:08:01ZAre Dilated Fundus Examinations Needed for OCT-Guided Retreatment of Exudative Age-Related Macular Degeneration? A Prospective, Randomized, Pilot Study1177-5483https://doaj.org/article/a9ff6d23695247d6bddab7d9ce49adde2021-08-01T00:00:00Zhttps://www.dovepress.com/are-dilated-fundus-examinations-needed-for-oct-guided-retreatment-of-e-peer-reviewed-fulltext-article-OPTHhttps://doaj.org/toc/1177-5483Sharon D Solomon,1 Victoria Kyerematen,2 Madiha Qutab,3 Adam S Wenick,1 Jiangxia Wang,4 Barbara S Hawkins1,4 1Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD, USA; 2Bloomfield Court Hospital, National Health Services, London, UK; 3Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA; 4Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USACorrespondence: Sharon D Solomon Email ssolomon1@jhmi.eduPurpose: To report findings when dilated fundus examination (DFE) is omitted from follow-up of patients receiving anti-VEGF injections for neovascular age-related macular degeneration (NVAMD).Design: Randomized pilot study.Participants: NVAMD patients with two or more injections of anti-VEGF within prior six months who were expected to require treatment for at least eight more months.Methods and Interventions: Participants were assigned to either retinal imaging and DFE or retinal imaging without a DFE except at 16 weeks and 32 weeks and at study completion.Outcomes: Primary safety outcomes were change in usual-corrected visual acuity (UCVA) and central subfield thickness (CST). Primary efficacy outcomes included time spent in clinic and patient satisfaction with clinic visits.Results: The 66 participants had mean baseline UCVA of 20/50 in the study eye. Median change in UCVA from baseline to each clinic visit in each arm was “no change”. Mean change in CST was less than 15 microns from baseline to any follow-up clinic visit. Time spent in the clinic at follow-up visits averaged 20 minutes less for participants in the Imaging Only group than those in the Full Exam group. More participants in the Imaging Only group were satisfied with the time spent in clinic and with the clinic visits overall than participants in the Full Exam group: means of 71 vs 91 minutes, respectively, per clinic visit.Conclusion: Based on findings from this randomized pilot study, follow-up retina clinic visits for established patients who have NVAMD and are under treatment with intravitreous injection of anti-VEGF agents could be streamlined by implementing longer intervals between DFE and by relying on imaging alone to make most decisions regarding the need for retreatment, thereby reducing the time spent by patients in clinic and increasing their satisfaction with care received, without excess adverse events.Trial Registration: NCT02251366.Keywords: neovascular age-related macular degeneration, anti-VEGF injection, time in clinicSolomon SDKyerematen VQutab MWenick ASWang JHawkins BSDove Medical Pressarticleneovascular age-related macular degenerationanti-vegf injectiontime in clinicOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 15, Pp 3401-3417 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	neovascular age-related macular degeneration anti-vegf injection time in clinic Ophthalmology RE1-994
spellingShingle	neovascular age-related macular degeneration anti-vegf injection time in clinic Ophthalmology RE1-994 Solomon SD Kyerematen V Qutab M Wenick AS Wang J Hawkins BS Are Dilated Fundus Examinations Needed for OCT-Guided Retreatment of Exudative Age-Related Macular Degeneration? A Prospective, Randomized, Pilot Study
description	Sharon D Solomon,1 Victoria Kyerematen,2 Madiha Qutab,3 Adam S Wenick,1 Jiangxia Wang,4 Barbara S Hawkins1,4 1Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD, USA; 2Bloomfield Court Hospital, National Health Services, London, UK; 3Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA; 4Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USACorrespondence: Sharon D Solomon Email ssolomon1@jhmi.eduPurpose: To report findings when dilated fundus examination (DFE) is omitted from follow-up of patients receiving anti-VEGF injections for neovascular age-related macular degeneration (NVAMD).Design: Randomized pilot study.Participants: NVAMD patients with two or more injections of anti-VEGF within prior six months who were expected to require treatment for at least eight more months.Methods and Interventions: Participants were assigned to either retinal imaging and DFE or retinal imaging without a DFE except at 16 weeks and 32 weeks and at study completion.Outcomes: Primary safety outcomes were change in usual-corrected visual acuity (UCVA) and central subfield thickness (CST). Primary efficacy outcomes included time spent in clinic and patient satisfaction with clinic visits.Results: The 66 participants had mean baseline UCVA of 20/50 in the study eye. Median change in UCVA from baseline to each clinic visit in each arm was “no change”. Mean change in CST was less than 15 microns from baseline to any follow-up clinic visit. Time spent in the clinic at follow-up visits averaged 20 minutes less for participants in the Imaging Only group than those in the Full Exam group. More participants in the Imaging Only group were satisfied with the time spent in clinic and with the clinic visits overall than participants in the Full Exam group: means of 71 vs 91 minutes, respectively, per clinic visit.Conclusion: Based on findings from this randomized pilot study, follow-up retina clinic visits for established patients who have NVAMD and are under treatment with intravitreous injection of anti-VEGF agents could be streamlined by implementing longer intervals between DFE and by relying on imaging alone to make most decisions regarding the need for retreatment, thereby reducing the time spent by patients in clinic and increasing their satisfaction with care received, without excess adverse events.Trial Registration: NCT02251366.Keywords: neovascular age-related macular degeneration, anti-VEGF injection, time in clinic
format	article
author	Solomon SD Kyerematen V Qutab M Wenick AS Wang J Hawkins BS
author_facet	Solomon SD Kyerematen V Qutab M Wenick AS Wang J Hawkins BS
author_sort	Solomon SD
title	Are Dilated Fundus Examinations Needed for OCT-Guided Retreatment of Exudative Age-Related Macular Degeneration? A Prospective, Randomized, Pilot Study
title_short	Are Dilated Fundus Examinations Needed for OCT-Guided Retreatment of Exudative Age-Related Macular Degeneration? A Prospective, Randomized, Pilot Study
title_full	Are Dilated Fundus Examinations Needed for OCT-Guided Retreatment of Exudative Age-Related Macular Degeneration? A Prospective, Randomized, Pilot Study
title_fullStr	Are Dilated Fundus Examinations Needed for OCT-Guided Retreatment of Exudative Age-Related Macular Degeneration? A Prospective, Randomized, Pilot Study
title_full_unstemmed	Are Dilated Fundus Examinations Needed for OCT-Guided Retreatment of Exudative Age-Related Macular Degeneration? A Prospective, Randomized, Pilot Study
title_sort	are dilated fundus examinations needed for oct-guided retreatment of exudative age-related macular degeneration? a prospective, randomized, pilot study
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/a9ff6d23695247d6bddab7d9ce49adde
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Are Dilated Fundus Examinations Needed for OCT-Guided Retreatment of Exudative Age-Related Macular Degeneration? A Prospective, Randomized, Pilot Study

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