Antibiotics: Combatting Tolerance To Stop Resistance

ABSTRACT Antibiotic resistance poses an alarming and ever-increasing threat to modern health care. Although the current antibiotic crisis is widely acknowledged, actions taken so far have proved insufficient to slow down the rampant spread of resistant pathogens. Problematically, routine screening m...

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Autores principales:	Etthel M. Windels, Joran E. Michiels, Bram Van den Bergh, Maarten Fauvart, Jan Michiels
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2019
Materias:	antibiotic resistance antibiotics evolution persistence Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/a9ffdb274011483bbbc56301d959b350
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spelling	oai:doaj.org-article:a9ffdb274011483bbbc56301d959b3502021-11-15T15:59:42ZAntibiotics: Combatting Tolerance To Stop Resistance10.1128/mBio.02095-192150-7511https://doaj.org/article/a9ffdb274011483bbbc56301d959b3502019-10-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.02095-19https://doaj.org/toc/2150-7511ABSTRACT Antibiotic resistance poses an alarming and ever-increasing threat to modern health care. Although the current antibiotic crisis is widely acknowledged, actions taken so far have proved insufficient to slow down the rampant spread of resistant pathogens. Problematically, routine screening methods and strategies to restrict therapy failure almost exclusively focus on genetic resistance, while evidence for dangers posed by other bacterial survival strategies is mounting. Antibiotic tolerance, occurring either population-wide or in a subpopulation of cells, allows bacteria to transiently overcome antibiotic treatment and is overlooked in clinical practice. In addition to prolonging treatment and causing relapsing infections, recent studies have revealed that tolerance also accelerates the emergence of resistance. These critical findings emphasize the need for strategies to combat tolerance, not only to improve treatment of recurrent infections but also to effectively address the problem of antibiotic resistance at the root.Etthel M. WindelsJoran E. MichielsBram Van den BerghMaarten FauvartJan MichielsAmerican Society for Microbiologyarticleantibiotic resistanceantibioticsevolutionpersistenceMicrobiologyQR1-502ENmBio, Vol 10, Iss 5 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	antibiotic resistance antibiotics evolution persistence Microbiology QR1-502
spellingShingle	antibiotic resistance antibiotics evolution persistence Microbiology QR1-502 Etthel M. Windels Joran E. Michiels Bram Van den Bergh Maarten Fauvart Jan Michiels Antibiotics: Combatting Tolerance To Stop Resistance
description	ABSTRACT Antibiotic resistance poses an alarming and ever-increasing threat to modern health care. Although the current antibiotic crisis is widely acknowledged, actions taken so far have proved insufficient to slow down the rampant spread of resistant pathogens. Problematically, routine screening methods and strategies to restrict therapy failure almost exclusively focus on genetic resistance, while evidence for dangers posed by other bacterial survival strategies is mounting. Antibiotic tolerance, occurring either population-wide or in a subpopulation of cells, allows bacteria to transiently overcome antibiotic treatment and is overlooked in clinical practice. In addition to prolonging treatment and causing relapsing infections, recent studies have revealed that tolerance also accelerates the emergence of resistance. These critical findings emphasize the need for strategies to combat tolerance, not only to improve treatment of recurrent infections but also to effectively address the problem of antibiotic resistance at the root.
format	article
author	Etthel M. Windels Joran E. Michiels Bram Van den Bergh Maarten Fauvart Jan Michiels
author_facet	Etthel M. Windels Joran E. Michiels Bram Van den Bergh Maarten Fauvart Jan Michiels
author_sort	Etthel M. Windels
title	Antibiotics: Combatting Tolerance To Stop Resistance
title_short	Antibiotics: Combatting Tolerance To Stop Resistance
title_full	Antibiotics: Combatting Tolerance To Stop Resistance
title_fullStr	Antibiotics: Combatting Tolerance To Stop Resistance
title_full_unstemmed	Antibiotics: Combatting Tolerance To Stop Resistance
title_sort	antibiotics: combatting tolerance to stop resistance
publisher	American Society for Microbiology
publishDate	2019
url	https://doaj.org/article/a9ffdb274011483bbbc56301d959b350
work_keys_str_mv	AT etthelmwindels antibioticscombattingtolerancetostopresistance AT joranemichiels antibioticscombattingtolerancetostopresistance AT bramvandenbergh antibioticscombattingtolerancetostopresistance AT maartenfauvart antibioticscombattingtolerancetostopresistance AT janmichiels antibioticscombattingtolerancetostopresistance
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Antibiotics: Combatting Tolerance To Stop Resistance

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