Statin on insulin and adiponectin levels: true or false prophecy?

Venu Gopal Jonnalagadda,1 Afsar Shaik21Department of Pharmacology & Toxicology, National Institute of Pharmaceutical Education and Research, Bhangagarh, Guwahati, Assam, India; 2Department of Pharmacology, Narayana Pharmacy College, Chinthareddy Palem, Nellore, Andhra Pradesh, IndiaWe read t...

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Autores principales:	Jonnalagadda VG, Shaik A
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	Insulin Adipokines type 2 diabetes mellitus glucose Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/aa03c57f733a4cecae1bf54bb98fec3a
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spelling	oai:doaj.org-article:aa03c57f733a4cecae1bf54bb98fec3a2021-12-02T07:28:34ZStatin on insulin and adiponectin levels: true or false prophecy?1178-7007https://doaj.org/article/aa03c57f733a4cecae1bf54bb98fec3a2018-04-01T00:00:00Zhttps://www.dovepress.com/statin-on-insulin-and-adiponectin-levels-true-or-false-prophecy-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Venu Gopal Jonnalagadda,1 Afsar Shaik21Department of Pharmacology & Toxicology, National Institute of Pharmaceutical Education and Research, Bhangagarh, Guwahati, Assam, India; 2Department of Pharmacology, Narayana Pharmacy College, Chinthareddy Palem, Nellore, Andhra Pradesh, IndiaWe read the article “Effect of different doses of statins on the development of type 2 diabetes mellitus in patients with myocardial infarction” by Gruzdeva et al1 with interest. The authors conducted a prospective cohort study on patients with diagnosed myocardial infarction who were on different doses of atorvastatin, ie, 20 mg/d or 40 mg/d, for new onset of diabetes for a duration of 12 months.Authors’ replyEvgenya Uchasova, Olga GruzdevaFederal State Budgetary Institution, Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo, Russian FederationWe would like to thank Venu Gopal Jonnalagadda and Afsar Shaik for the letter in response to our article.1 Yes, indeed in our study, statins at a dose of 20 and 40 mg/mL, at 20 mg/d atorvastatin, were observed to improve the sensitivity to insulin and eliminate adipokine imbalance and ghrelin deficiency. At a dose of 40 mg/d, atorvastatin showed increased negative effects, such as a reduction in insulin secretion, hyperglycemia, impaired glucose tolerance, high levels of leptin, ghrelin deficiency, and manifestation of type 2 diabetes mellitus. Statins at a dose of 80 mg/mL were not included in this work; however, at this dose in this study, we observed a decrease in levels of adiponectin and insulin.1View the original paper by Gruzdeva and colleagues.Jonnalagadda VGShaik ADove Medical PressarticleInsulinAdipokinestype 2 diabetes mellitusglucoseSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 11, Pp 131-132 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Insulin Adipokines type 2 diabetes mellitus glucose Specialties of internal medicine RC581-951
spellingShingle	Insulin Adipokines type 2 diabetes mellitus glucose Specialties of internal medicine RC581-951 Jonnalagadda VG Shaik A Statin on insulin and adiponectin levels: true or false prophecy?
description	Venu Gopal Jonnalagadda,1 Afsar Shaik21Department of Pharmacology & Toxicology, National Institute of Pharmaceutical Education and Research, Bhangagarh, Guwahati, Assam, India; 2Department of Pharmacology, Narayana Pharmacy College, Chinthareddy Palem, Nellore, Andhra Pradesh, IndiaWe read the article “Effect of different doses of statins on the development of type 2 diabetes mellitus in patients with myocardial infarction” by Gruzdeva et al1 with interest. The authors conducted a prospective cohort study on patients with diagnosed myocardial infarction who were on different doses of atorvastatin, ie, 20 mg/d or 40 mg/d, for new onset of diabetes for a duration of 12 months.Authors’ replyEvgenya Uchasova, Olga GruzdevaFederal State Budgetary Institution, Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo, Russian FederationWe would like to thank Venu Gopal Jonnalagadda and Afsar Shaik for the letter in response to our article.1 Yes, indeed in our study, statins at a dose of 20 and 40 mg/mL, at 20 mg/d atorvastatin, were observed to improve the sensitivity to insulin and eliminate adipokine imbalance and ghrelin deficiency. At a dose of 40 mg/d, atorvastatin showed increased negative effects, such as a reduction in insulin secretion, hyperglycemia, impaired glucose tolerance, high levels of leptin, ghrelin deficiency, and manifestation of type 2 diabetes mellitus. Statins at a dose of 80 mg/mL were not included in this work; however, at this dose in this study, we observed a decrease in levels of adiponectin and insulin.1View the original paper by Gruzdeva and colleagues.
format	article
author	Jonnalagadda VG Shaik A
author_facet	Jonnalagadda VG Shaik A
author_sort	Jonnalagadda VG
title	Statin on insulin and adiponectin levels: true or false prophecy?
title_short	Statin on insulin and adiponectin levels: true or false prophecy?
title_full	Statin on insulin and adiponectin levels: true or false prophecy?
title_fullStr	Statin on insulin and adiponectin levels: true or false prophecy?
title_full_unstemmed	Statin on insulin and adiponectin levels: true or false prophecy?
title_sort	statin on insulin and adiponectin levels: true or false prophecy?
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/aa03c57f733a4cecae1bf54bb98fec3a
work_keys_str_mv	AT jonnalagaddavg statinoninsulinandadiponectinlevelstrueorfalseprophecy AT shaika statinoninsulinandadiponectinlevelstrueorfalseprophecy
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Statin on insulin and adiponectin levels: true or false prophecy?

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