Cryo-EM of mammalian PA28αβ-iCP immunoproteasome reveals a distinct mechanism of proteasome activation by PA28αβ

The proteasome activator PA28αβ affects MHC class I antigen presentation by associating with immunoproteasome core particles (iCPs). Cryo-EM structures of the mammalian PA28αβ -iCP immunoproteasome and free iCP, combined with cross-linking data, reveal the complex architecture and suggest a distinct...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Jinhuan Chen, Yifan Wang, Cong Xu, Kaijian Chen, Qiaoyu Zhao, Shutian Wang, Yue Yin, Chao Peng, Zhanyu Ding, Yao Cong
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/aa03cc969f924ebc806c416e0c938a9d
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:aa03cc969f924ebc806c416e0c938a9d
record_format	dspace
spelling	oai:doaj.org-article:aa03cc969f924ebc806c416e0c938a9d2021-12-02T14:06:10ZCryo-EM of mammalian PA28αβ-iCP immunoproteasome reveals a distinct mechanism of proteasome activation by PA28αβ10.1038/s41467-021-21028-32041-1723https://doaj.org/article/aa03cc969f924ebc806c416e0c938a9d2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21028-3https://doaj.org/toc/2041-1723The proteasome activator PA28αβ affects MHC class I antigen presentation by associating with immunoproteasome core particles (iCPs). Cryo-EM structures of the mammalian PA28αβ -iCP immunoproteasome and free iCP, combined with cross-linking data, reveal the complex architecture and suggest a distinct immunoproteasome activation mechanism.Jinhuan ChenYifan WangCong XuKaijian ChenQiaoyu ZhaoShutian WangYue YinChao PengZhanyu DingYao CongNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jinhuan Chen Yifan Wang Cong Xu Kaijian Chen Qiaoyu Zhao Shutian Wang Yue Yin Chao Peng Zhanyu Ding Yao Cong Cryo-EM of mammalian PA28αβ-iCP immunoproteasome reveals a distinct mechanism of proteasome activation by PA28αβ
description	The proteasome activator PA28αβ affects MHC class I antigen presentation by associating with immunoproteasome core particles (iCPs). Cryo-EM structures of the mammalian PA28αβ -iCP immunoproteasome and free iCP, combined with cross-linking data, reveal the complex architecture and suggest a distinct immunoproteasome activation mechanism.
format	article
author	Jinhuan Chen Yifan Wang Cong Xu Kaijian Chen Qiaoyu Zhao Shutian Wang Yue Yin Chao Peng Zhanyu Ding Yao Cong
author_facet	Jinhuan Chen Yifan Wang Cong Xu Kaijian Chen Qiaoyu Zhao Shutian Wang Yue Yin Chao Peng Zhanyu Ding Yao Cong
author_sort	Jinhuan Chen
title	Cryo-EM of mammalian PA28αβ-iCP immunoproteasome reveals a distinct mechanism of proteasome activation by PA28αβ
title_short	Cryo-EM of mammalian PA28αβ-iCP immunoproteasome reveals a distinct mechanism of proteasome activation by PA28αβ
title_full	Cryo-EM of mammalian PA28αβ-iCP immunoproteasome reveals a distinct mechanism of proteasome activation by PA28αβ
title_fullStr	Cryo-EM of mammalian PA28αβ-iCP immunoproteasome reveals a distinct mechanism of proteasome activation by PA28αβ
title_full_unstemmed	Cryo-EM of mammalian PA28αβ-iCP immunoproteasome reveals a distinct mechanism of proteasome activation by PA28αβ
title_sort	cryo-em of mammalian pa28αβ-icp immunoproteasome reveals a distinct mechanism of proteasome activation by pa28αβ
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/aa03cc969f924ebc806c416e0c938a9d
work_keys_str_mv	AT jinhuanchen cryoemofmammalianpa28abicpimmunoproteasomerevealsadistinctmechanismofproteasomeactivationbypa28ab AT yifanwang cryoemofmammalianpa28abicpimmunoproteasomerevealsadistinctmechanismofproteasomeactivationbypa28ab AT congxu cryoemofmammalianpa28abicpimmunoproteasomerevealsadistinctmechanismofproteasomeactivationbypa28ab AT kaijianchen cryoemofmammalianpa28abicpimmunoproteasomerevealsadistinctmechanismofproteasomeactivationbypa28ab AT qiaoyuzhao cryoemofmammalianpa28abicpimmunoproteasomerevealsadistinctmechanismofproteasomeactivationbypa28ab AT shutianwang cryoemofmammalianpa28abicpimmunoproteasomerevealsadistinctmechanismofproteasomeactivationbypa28ab AT yueyin cryoemofmammalianpa28abicpimmunoproteasomerevealsadistinctmechanismofproteasomeactivationbypa28ab AT chaopeng cryoemofmammalianpa28abicpimmunoproteasomerevealsadistinctmechanismofproteasomeactivationbypa28ab AT zhanyuding cryoemofmammalianpa28abicpimmunoproteasomerevealsadistinctmechanismofproteasomeactivationbypa28ab AT yaocong cryoemofmammalianpa28abicpimmunoproteasomerevealsadistinctmechanismofproteasomeactivationbypa28ab
_version_	1718392041010888704

Cryo-EM of mammalian PA28αβ-iCP immunoproteasome reveals a distinct mechanism of proteasome activation by PA28αβ

Ejemplares similares