Variant surface glycoprotein density defines an immune evasion threshold for African trypanosomes undergoing antigenic variation

Trypanosoma brucei evades the host immune system through replacement of a variant surface glycoprotein (VSG) coat. Here, the authors show that VSG replacement takes several days to complete, and the parasite is vulnerable to the host immune system for a short period of time during the process.

Guardado en:

Detalles Bibliográficos
Autores principales:	Jason Pinger, Shanin Chowdhury, F. Nina Papavasiliou
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/aa06b14acc704be0b85627d28f67eda1
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:aa06b14acc704be0b85627d28f67eda1
record_format	dspace
spelling	oai:doaj.org-article:aa06b14acc704be0b85627d28f67eda12021-12-02T17:06:23ZVariant surface glycoprotein density defines an immune evasion threshold for African trypanosomes undergoing antigenic variation10.1038/s41467-017-00959-w2041-1723https://doaj.org/article/aa06b14acc704be0b85627d28f67eda12017-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00959-whttps://doaj.org/toc/2041-1723Trypanosoma brucei evades the host immune system through replacement of a variant surface glycoprotein (VSG) coat. Here, the authors show that VSG replacement takes several days to complete, and the parasite is vulnerable to the host immune system for a short period of time during the process.Jason PingerShanin ChowdhuryF. Nina PapavasiliouNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jason Pinger Shanin Chowdhury F. Nina Papavasiliou Variant surface glycoprotein density defines an immune evasion threshold for African trypanosomes undergoing antigenic variation
description	Trypanosoma brucei evades the host immune system through replacement of a variant surface glycoprotein (VSG) coat. Here, the authors show that VSG replacement takes several days to complete, and the parasite is vulnerable to the host immune system for a short period of time during the process.
format	article
author	Jason Pinger Shanin Chowdhury F. Nina Papavasiliou
author_facet	Jason Pinger Shanin Chowdhury F. Nina Papavasiliou
author_sort	Jason Pinger
title	Variant surface glycoprotein density defines an immune evasion threshold for African trypanosomes undergoing antigenic variation
title_short	Variant surface glycoprotein density defines an immune evasion threshold for African trypanosomes undergoing antigenic variation
title_full	Variant surface glycoprotein density defines an immune evasion threshold for African trypanosomes undergoing antigenic variation
title_fullStr	Variant surface glycoprotein density defines an immune evasion threshold for African trypanosomes undergoing antigenic variation
title_full_unstemmed	Variant surface glycoprotein density defines an immune evasion threshold for African trypanosomes undergoing antigenic variation
title_sort	variant surface glycoprotein density defines an immune evasion threshold for african trypanosomes undergoing antigenic variation
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/aa06b14acc704be0b85627d28f67eda1
work_keys_str_mv	AT jasonpinger variantsurfaceglycoproteindensitydefinesanimmuneevasionthresholdforafricantrypanosomesundergoingantigenicvariation AT shaninchowdhury variantsurfaceglycoproteindensitydefinesanimmuneevasionthresholdforafricantrypanosomesundergoingantigenicvariation AT fninapapavasiliou variantsurfaceglycoproteindensitydefinesanimmuneevasionthresholdforafricantrypanosomesundergoingantigenicvariation
_version_	1718381630429593600

Variant surface glycoprotein density defines an immune evasion threshold for African trypanosomes undergoing antigenic variation

Ejemplares similares