Impact of obesity on the clinical profile of a population-based sample with chronic obstructive pulmonary disease.

<h4>Aims</h4>To characterize the distribution of BMI in a population-based sample of COPD patients and to evaluate the impact of obesity on their health status, exercise tolerance, systemic inflammation and comorbidity.<h4>Methods</h4>A population-based sample of 3,797 subjec...

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Autores principales:	Francisco García-Rio, Joan B Soriano, Marc Miravitlles, Luis Muñoz, Enric Duran-Tauleria, Guadalupe Sánchez, Victor Sobradillo, Julio Ancochea
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/aa09088d0d104592a1a911f7f550b810
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spelling	oai:doaj.org-article:aa09088d0d104592a1a911f7f550b8102021-11-25T06:03:21ZImpact of obesity on the clinical profile of a population-based sample with chronic obstructive pulmonary disease.1932-620310.1371/journal.pone.0105220https://doaj.org/article/aa09088d0d104592a1a911f7f550b8102014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/25153331/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Aims</h4>To characterize the distribution of BMI in a population-based sample of COPD patients and to evaluate the impact of obesity on their health status, exercise tolerance, systemic inflammation and comorbidity.<h4>Methods</h4>A population-based sample of 3,797 subjects aged 40-80 years from the EPI-SCAN study was selected. Subjects were categorized according their body mass index (BMI) as underweight (<18.5 kg/m2), normal weight (18.5-24.9 kg/m2), overweight (25.0-29.9 kg/m2) or obese (BMI≥30.0 kg/m2). Subjects were evaluated with post-bronchodilator spirometry and 6-minute walk tests. Smoking habits, respiratory symptoms, generic and specific quality of life, daily physical activities, comorbidities and systemic inflammatory biomarkers were recorded.<h4>Results</h4>The prevalence of obesity or being overweight was higher in the 382 COPD patients than in the subjects without airflow limitation (29.4%, 95%CI 24.8-33.9% vs. 24.3, 95%CI 22.9-25.8; and 44.7%, 95%CI 39.7-49.6% vs. 43.0%, 95%CI 41.3-44.6, respectively; p = 0.020). In the COPD subgroup, obese subjects presented more dyspnea and less chronic cough, chronic bronchitis or chronic phlegm than normal-weight patients, as well as a worse health status. Moreover, reduced exercise tolerance and higher plasmatic C-reactive protein levels were found in the obese patients, who also presented a greater prevalence of cardiovascular disease (adjusted odds ratio 4.796, 95%CI 1.806-12.736, p = 0.002).<h4>Conclusions</h4>In a population-based sample, obesity is more prevalent in COPD patients than in subjects without airflow limitation. Furthermore, obesity affects the clinical manifestations, quality of life and exercise tolerance of COPD patients, and it may contribute to a phenotype characterized by increased systemic inflammation and greater frequency of cardiovascular comorbidity.Francisco García-RioJoan B SorianoMarc MiravitllesLuis MuñozEnric Duran-TauleriaGuadalupe SánchezVictor SobradilloJulio AncocheaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 8, p e105220 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Francisco García-Rio Joan B Soriano Marc Miravitlles Luis Muñoz Enric Duran-Tauleria Guadalupe Sánchez Victor Sobradillo Julio Ancochea Impact of obesity on the clinical profile of a population-based sample with chronic obstructive pulmonary disease.
description	<h4>Aims</h4>To characterize the distribution of BMI in a population-based sample of COPD patients and to evaluate the impact of obesity on their health status, exercise tolerance, systemic inflammation and comorbidity.<h4>Methods</h4>A population-based sample of 3,797 subjects aged 40-80 years from the EPI-SCAN study was selected. Subjects were categorized according their body mass index (BMI) as underweight (<18.5 kg/m2), normal weight (18.5-24.9 kg/m2), overweight (25.0-29.9 kg/m2) or obese (BMI≥30.0 kg/m2). Subjects were evaluated with post-bronchodilator spirometry and 6-minute walk tests. Smoking habits, respiratory symptoms, generic and specific quality of life, daily physical activities, comorbidities and systemic inflammatory biomarkers were recorded.<h4>Results</h4>The prevalence of obesity or being overweight was higher in the 382 COPD patients than in the subjects without airflow limitation (29.4%, 95%CI 24.8-33.9% vs. 24.3, 95%CI 22.9-25.8; and 44.7%, 95%CI 39.7-49.6% vs. 43.0%, 95%CI 41.3-44.6, respectively; p = 0.020). In the COPD subgroup, obese subjects presented more dyspnea and less chronic cough, chronic bronchitis or chronic phlegm than normal-weight patients, as well as a worse health status. Moreover, reduced exercise tolerance and higher plasmatic C-reactive protein levels were found in the obese patients, who also presented a greater prevalence of cardiovascular disease (adjusted odds ratio 4.796, 95%CI 1.806-12.736, p = 0.002).<h4>Conclusions</h4>In a population-based sample, obesity is more prevalent in COPD patients than in subjects without airflow limitation. Furthermore, obesity affects the clinical manifestations, quality of life and exercise tolerance of COPD patients, and it may contribute to a phenotype characterized by increased systemic inflammation and greater frequency of cardiovascular comorbidity.
format	article
author	Francisco García-Rio Joan B Soriano Marc Miravitlles Luis Muñoz Enric Duran-Tauleria Guadalupe Sánchez Victor Sobradillo Julio Ancochea
author_facet	Francisco García-Rio Joan B Soriano Marc Miravitlles Luis Muñoz Enric Duran-Tauleria Guadalupe Sánchez Victor Sobradillo Julio Ancochea
author_sort	Francisco García-Rio
title	Impact of obesity on the clinical profile of a population-based sample with chronic obstructive pulmonary disease.
title_short	Impact of obesity on the clinical profile of a population-based sample with chronic obstructive pulmonary disease.
title_full	Impact of obesity on the clinical profile of a population-based sample with chronic obstructive pulmonary disease.
title_fullStr	Impact of obesity on the clinical profile of a population-based sample with chronic obstructive pulmonary disease.
title_full_unstemmed	Impact of obesity on the clinical profile of a population-based sample with chronic obstructive pulmonary disease.
title_sort	impact of obesity on the clinical profile of a population-based sample with chronic obstructive pulmonary disease.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/aa09088d0d104592a1a911f7f550b810
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Impact of obesity on the clinical profile of a population-based sample with chronic obstructive pulmonary disease.

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