Similarities and differences in patterns of germline mutation between mice and humans

Estimates of mutation rates differ between species. Here, Lindsay et al. perform side-by-side analyses of germline mutation rates using multi-sibling mouse and human pedigrees and find different mutation rates between species, also stratified by sex and temporal stage of mutation acquisition.

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Detalles Bibliográficos
Autores principales: Sarah J. Lindsay, Raheleh Rahbari, Joanna Kaplanis, Thomas Keane, Matthew E. Hurles
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/aa0dc48964e54ac386e118a6c152dd33
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Descripción
Sumario:Estimates of mutation rates differ between species. Here, Lindsay et al. perform side-by-side analyses of germline mutation rates using multi-sibling mouse and human pedigrees and find different mutation rates between species, also stratified by sex and temporal stage of mutation acquisition.