Similarities and differences in patterns of germline mutation between mice and humans

Estimates of mutation rates differ between species. Here, Lindsay et al. perform side-by-side analyses of germline mutation rates using multi-sibling mouse and human pedigrees and find different mutation rates between species, also stratified by sex and temporal stage of mutation acquisition.

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Autores principales:	Sarah J. Lindsay, Raheleh Rahbari, Joanna Kaplanis, Thomas Keane, Matthew E. Hurles
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/aa0dc48964e54ac386e118a6c152dd33
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spelling	oai:doaj.org-article:aa0dc48964e54ac386e118a6c152dd332021-12-02T15:36:22ZSimilarities and differences in patterns of germline mutation between mice and humans10.1038/s41467-019-12023-w2041-1723https://doaj.org/article/aa0dc48964e54ac386e118a6c152dd332019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12023-whttps://doaj.org/toc/2041-1723Estimates of mutation rates differ between species. Here, Lindsay et al. perform side-by-side analyses of germline mutation rates using multi-sibling mouse and human pedigrees and find different mutation rates between species, also stratified by sex and temporal stage of mutation acquisition.Sarah J. LindsayRaheleh RahbariJoanna KaplanisThomas KeaneMatthew E. HurlesNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sarah J. Lindsay Raheleh Rahbari Joanna Kaplanis Thomas Keane Matthew E. Hurles Similarities and differences in patterns of germline mutation between mice and humans
description	Estimates of mutation rates differ between species. Here, Lindsay et al. perform side-by-side analyses of germline mutation rates using multi-sibling mouse and human pedigrees and find different mutation rates between species, also stratified by sex and temporal stage of mutation acquisition.
format	article
author	Sarah J. Lindsay Raheleh Rahbari Joanna Kaplanis Thomas Keane Matthew E. Hurles
author_facet	Sarah J. Lindsay Raheleh Rahbari Joanna Kaplanis Thomas Keane Matthew E. Hurles
author_sort	Sarah J. Lindsay
title	Similarities and differences in patterns of germline mutation between mice and humans
title_short	Similarities and differences in patterns of germline mutation between mice and humans
title_full	Similarities and differences in patterns of germline mutation between mice and humans
title_fullStr	Similarities and differences in patterns of germline mutation between mice and humans
title_full_unstemmed	Similarities and differences in patterns of germline mutation between mice and humans
title_sort	similarities and differences in patterns of germline mutation between mice and humans
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/aa0dc48964e54ac386e118a6c152dd33
work_keys_str_mv	AT sarahjlindsay similaritiesanddifferencesinpatternsofgermlinemutationbetweenmiceandhumans AT rahelehrahbari similaritiesanddifferencesinpatternsofgermlinemutationbetweenmiceandhumans AT joannakaplanis similaritiesanddifferencesinpatternsofgermlinemutationbetweenmiceandhumans AT thomaskeane similaritiesanddifferencesinpatternsofgermlinemutationbetweenmiceandhumans AT matthewehurles similaritiesanddifferencesinpatternsofgermlinemutationbetweenmiceandhumans
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Similarities and differences in patterns of germline mutation between mice and humans

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