Inhibitory mechanism of reveromycin A at the tRNA binding site of a class I synthetase

Reveromycin A (RM-A) selectively inhibits eukaryotic cytoplasmic isoleucyltRNA synthetase (IleRS). Herein, the authors show that RM-A molecule occupies the tRNAIle binding site of Saccharomyces cerevisiae IleRS, and that RM-A cooperates with isoleucine or isoleucyl-adenylate for IleRS binding.

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Main Authors:	Bingyi Chen, Siting Luo, Songxuan Zhang, Yingchen Ju, Qiong Gu, Jun Xu, Xiang-Lei Yang, Huihao Zhou
Format:	article
Language:	EN
Published:	Nature Portfolio 2021
Subjects:	Science Q
Online Access:	https://doaj.org/article/aa106fd7577240a4b8e1ff9e7d96b4fa
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spelling	oai:doaj.org-article:aa106fd7577240a4b8e1ff9e7d96b4fa2021-12-02T13:16:18ZInhibitory mechanism of reveromycin A at the tRNA binding site of a class I synthetase10.1038/s41467-021-21902-02041-1723https://doaj.org/article/aa106fd7577240a4b8e1ff9e7d96b4fa2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21902-0https://doaj.org/toc/2041-1723Reveromycin A (RM-A) selectively inhibits eukaryotic cytoplasmic isoleucyltRNA synthetase (IleRS). Herein, the authors show that RM-A molecule occupies the tRNAIle binding site of Saccharomyces cerevisiae IleRS, and that RM-A cooperates with isoleucine or isoleucyl-adenylate for IleRS binding.Bingyi ChenSiting LuoSongxuan ZhangYingchen JuQiong GuJun XuXiang-Lei YangHuihao ZhouNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Bingyi Chen Siting Luo Songxuan Zhang Yingchen Ju Qiong Gu Jun Xu Xiang-Lei Yang Huihao Zhou Inhibitory mechanism of reveromycin A at the tRNA binding site of a class I synthetase
description	Reveromycin A (RM-A) selectively inhibits eukaryotic cytoplasmic isoleucyltRNA synthetase (IleRS). Herein, the authors show that RM-A molecule occupies the tRNAIle binding site of Saccharomyces cerevisiae IleRS, and that RM-A cooperates with isoleucine or isoleucyl-adenylate for IleRS binding.
format	article
author	Bingyi Chen Siting Luo Songxuan Zhang Yingchen Ju Qiong Gu Jun Xu Xiang-Lei Yang Huihao Zhou
author_facet	Bingyi Chen Siting Luo Songxuan Zhang Yingchen Ju Qiong Gu Jun Xu Xiang-Lei Yang Huihao Zhou
author_sort	Bingyi Chen
title	Inhibitory mechanism of reveromycin A at the tRNA binding site of a class I synthetase
title_short	Inhibitory mechanism of reveromycin A at the tRNA binding site of a class I synthetase
title_full	Inhibitory mechanism of reveromycin A at the tRNA binding site of a class I synthetase
title_fullStr	Inhibitory mechanism of reveromycin A at the tRNA binding site of a class I synthetase
title_full_unstemmed	Inhibitory mechanism of reveromycin A at the tRNA binding site of a class I synthetase
title_sort	inhibitory mechanism of reveromycin a at the trna binding site of a class i synthetase
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/aa106fd7577240a4b8e1ff9e7d96b4fa
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Inhibitory mechanism of reveromycin A at the tRNA binding site of a class I synthetase

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