Altered heart rate dynamics associated with antipsychotic-induced subjective restlessness in patients with schizophrenia

Jong-Hoon Kim,1,2 Jun-Hyung Ann,2 Jinyoung Lee,1 Mee-Hee Kim,1 Ah-Young Han1 1Department of Psychiatry, Gil Medical Center, 2Graduate School of Medicine, Gachon University, Incheon, South Korea Background: Antipsychotic-induced subjective inner restlessness is one of the common and distressing adver...

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Autores principales:	Kim JH, Ann JH, Lee J, Kim MH, Han AY
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2013
Materias:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/aa11d8e4ed974b438556df129787863e
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spelling	oai:doaj.org-article:aa11d8e4ed974b438556df129787863e2021-12-02T07:43:51ZAltered heart rate dynamics associated with antipsychotic-induced subjective restlessness in patients with schizophrenia1176-63281178-2021https://doaj.org/article/aa11d8e4ed974b438556df129787863e2013-07-01T00:00:00Zhttp://www.dovepress.com/altered-heart-rate-dynamics-associated-with-antipsychotic-induced-subj-a13700https://doaj.org/toc/1176-6328https://doaj.org/toc/1178-2021Jong-Hoon Kim,1,2 Jun-Hyung Ann,2 Jinyoung Lee,1 Mee-Hee Kim,1 Ah-Young Han1 1Department of Psychiatry, Gil Medical Center, 2Graduate School of Medicine, Gachon University, Incheon, South Korea Background: Antipsychotic-induced subjective inner restlessness is one of the common and distressing adverse effects associated with antipsychotics; however, its underlying neurobiological basis is not well understood. We examined the relationship between antipsychotic-induced subjective inner restlessness and autonomic neurocardiac function. Methods: Twenty-two schizophrenia patients with antipsychotic-induced subjective restlessness, 28 schizophrenia patients without antipsychotic-induced subjective restlessness, and 28 matched healthy control subjects were evaluated. Assessments of the linear and nonlinear complexity measures of heart rate dynamics were performed. Multivariate analysis of variance and correlation analysis were conducted. Results: The mean interbeat (RR) interval value was significantly higher in control subjects than in patients with and without antipsychotic-induced subjective restlessness (P < 0.05). The low frequency/high frequency ratio was significantly higher in patients with antipsychotic-induced subjective restlessness than in control subjects and in patients without antipsychotic-induced subjective restlessness (P < 0.05), while the approximate entropy value was significantly lower in patients with antipsychotic-induced subjective restlessness than in control subjects and in patients without antipsychotic-induced subjective restlessness (P < 0.05). Correlation analyses controlling for psychotic symptom severity showed that the degree of antipsychotic-induced restlessness had a significant negative correlation with the value of approximate entropy (P < 0.05). Conclusion: The results indicate that antipsychotic-induced subjective restlessness is associated with altered heart rate dynamics parameters, particularly the nonlinear complexity measure, suggesting that it might adversely affect autonomic neurocardiac integrity. Further prospective research is necessary to elucidate the precise interrelationships and causality. Keywords: antipsychotics, subjective restlessness, heart rate dynamicsKim JHAnn JHLee JKim MHHan AYDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2013, Iss default, Pp 989-994 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Kim JH Ann JH Lee J Kim MH Han AY Altered heart rate dynamics associated with antipsychotic-induced subjective restlessness in patients with schizophrenia
description	Jong-Hoon Kim,1,2 Jun-Hyung Ann,2 Jinyoung Lee,1 Mee-Hee Kim,1 Ah-Young Han1 1Department of Psychiatry, Gil Medical Center, 2Graduate School of Medicine, Gachon University, Incheon, South Korea Background: Antipsychotic-induced subjective inner restlessness is one of the common and distressing adverse effects associated with antipsychotics; however, its underlying neurobiological basis is not well understood. We examined the relationship between antipsychotic-induced subjective inner restlessness and autonomic neurocardiac function. Methods: Twenty-two schizophrenia patients with antipsychotic-induced subjective restlessness, 28 schizophrenia patients without antipsychotic-induced subjective restlessness, and 28 matched healthy control subjects were evaluated. Assessments of the linear and nonlinear complexity measures of heart rate dynamics were performed. Multivariate analysis of variance and correlation analysis were conducted. Results: The mean interbeat (RR) interval value was significantly higher in control subjects than in patients with and without antipsychotic-induced subjective restlessness (P < 0.05). The low frequency/high frequency ratio was significantly higher in patients with antipsychotic-induced subjective restlessness than in control subjects and in patients without antipsychotic-induced subjective restlessness (P < 0.05), while the approximate entropy value was significantly lower in patients with antipsychotic-induced subjective restlessness than in control subjects and in patients without antipsychotic-induced subjective restlessness (P < 0.05). Correlation analyses controlling for psychotic symptom severity showed that the degree of antipsychotic-induced restlessness had a significant negative correlation with the value of approximate entropy (P < 0.05). Conclusion: The results indicate that antipsychotic-induced subjective restlessness is associated with altered heart rate dynamics parameters, particularly the nonlinear complexity measure, suggesting that it might adversely affect autonomic neurocardiac integrity. Further prospective research is necessary to elucidate the precise interrelationships and causality. Keywords: antipsychotics, subjective restlessness, heart rate dynamics
format	article
author	Kim JH Ann JH Lee J Kim MH Han AY
author_facet	Kim JH Ann JH Lee J Kim MH Han AY
author_sort	Kim JH
title	Altered heart rate dynamics associated with antipsychotic-induced subjective restlessness in patients with schizophrenia
title_short	Altered heart rate dynamics associated with antipsychotic-induced subjective restlessness in patients with schizophrenia
title_full	Altered heart rate dynamics associated with antipsychotic-induced subjective restlessness in patients with schizophrenia
title_fullStr	Altered heart rate dynamics associated with antipsychotic-induced subjective restlessness in patients with schizophrenia
title_full_unstemmed	Altered heart rate dynamics associated with antipsychotic-induced subjective restlessness in patients with schizophrenia
title_sort	altered heart rate dynamics associated with antipsychotic-induced subjective restlessness in patients with schizophrenia
publisher	Dove Medical Press
publishDate	2013
url	https://doaj.org/article/aa11d8e4ed974b438556df129787863e
work_keys_str_mv	AT kimjh alteredheartratedynamicsassociatedwithantipsychoticinducedsubjectiverestlessnessinpatientswithschizophrenia AT annjh alteredheartratedynamicsassociatedwithantipsychoticinducedsubjectiverestlessnessinpatientswithschizophrenia AT leej alteredheartratedynamicsassociatedwithantipsychoticinducedsubjectiverestlessnessinpatientswithschizophrenia AT kimmh alteredheartratedynamicsassociatedwithantipsychoticinducedsubjectiverestlessnessinpatientswithschizophrenia AT hanay alteredheartratedynamicsassociatedwithantipsychoticinducedsubjectiverestlessnessinpatientswithschizophrenia
_version_	1718399241731178496

Altered heart rate dynamics associated with antipsychotic-induced subjective restlessness in patients with schizophrenia

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