Carbonic Anhydrase Inhibition with Sulfonamides Incorporating Pyrazole- and Pyridazinecarboxamide Moieties Provides Examples of Isoform-Selective Inhibitors

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Carbonic Anhydrase Inhibition with Sulfonamides Incorporating Pyrazole- and Pyridazinecarboxamide Moieties Provides Examples of Isoform-Selective Inhibitors

A series of benzenesulfonamides incorporating pyrazole- and pyridazinecarboxamides decorated with several bulky moieties has been obtained by original procedures. The new derivatives were investigated for the inhibition of four physiologically crucial human carbonic anhydrase (hCA, EC 4.2.2.1.1) iso...

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Détails bibliographiques
Auteurs principaux:	Andrea Angeli, Victor Kartsev, Anthi Petrou, Mariana Pinteala, Volodymyr Brovarets, Roman Vydzhak, Svitlana Panchishin, Athina Geronikaki, Claudiu T. Supuran
Format:	article
Langue:	EN
Publié:	MDPI AG 2021
Sujets:	carbonic anhydrase inhibitors metalloenzymes pyrazole derivatives Organic chemistry QD241-441
Accès en ligne:	https://doaj.org/article/aa1769f52e1f4f7da32c13f9256e6dee
Tags:	Ajouter un tag Pas de tags, Soyez le premier à ajouter un tag!

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