Carbonic Anhydrase Inhibition with Sulfonamides Incorporating Pyrazole- and Pyridazinecarboxamide Moieties Provides Examples of Isoform-Selective Inhibitors

Carbonic Anhydrase Inhibition with Sulfonamides Incorporating Pyrazole- and Pyridazinecarboxamide Moieties Provides Examples of Isoform-Selective Inhibitors

A series of benzenesulfonamides incorporating pyrazole- and pyridazinecarboxamides decorated with several bulky moieties has been obtained by original procedures. The new derivatives were investigated for the inhibition of four physiologically crucial human carbonic anhydrase (hCA, EC 4.2.2.1.1) iso...

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Auteurs principaux: Andrea Angeli, Victor Kartsev, Anthi Petrou, Mariana Pinteala, Volodymyr Brovarets, Roman Vydzhak, Svitlana Panchishin, Athina Geronikaki, Claudiu T. Supuran
Format: article
Langue:EN
Publié: MDPI AG 2021
Sujets:
carbonic anhydrase
inhibitors
metalloenzymes
pyrazole derivatives
Organic chemistry
QD241-441
Accès en ligne:https://doaj.org/article/aa1769f52e1f4f7da32c13f9256e6dee
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Internet

https://doaj.org/article/aa1769f52e1f4f7da32c13f9256e6dee

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