Western-style diet consumption impairs maternal insulin sensitivity and glucose metabolism during pregnancy in a Japanese macaque model

Abstract The prevalence of maternal obesity is increasing in the United States. Offspring born to women with obesity or poor glycemic control have greater odds of becoming obese and developing metabolic disease later in life. Our group has utilized a macaque model to study the metabolic effects of c...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Joseph M. Elsakr, Sifang Kathy Zhao, Valerie Ricciardi, Tyler A. Dean, Diana L. Takahashi, Elinor Sullivan, Stephanie R. Wesolowski, Carrie E. McCurdy, Paul Kievit, Jacob E. Friedman, Kjersti M. Aagaard, Digna R. Velez Edwards, Maureen Gannon
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/aa19a82e9f5149fe9535985f2027cb5b
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:aa19a82e9f5149fe9535985f2027cb5b
record_format	dspace
spelling	oai:doaj.org-article:aa19a82e9f5149fe9535985f2027cb5b2021-12-02T16:07:04ZWestern-style diet consumption impairs maternal insulin sensitivity and glucose metabolism during pregnancy in a Japanese macaque model10.1038/s41598-021-92464-w2045-2322https://doaj.org/article/aa19a82e9f5149fe9535985f2027cb5b2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-92464-whttps://doaj.org/toc/2045-2322Abstract The prevalence of maternal obesity is increasing in the United States. Offspring born to women with obesity or poor glycemic control have greater odds of becoming obese and developing metabolic disease later in life. Our group has utilized a macaque model to study the metabolic effects of consumption of a calorically-dense, Western-style diet (WSD; 36.3% fat) during pregnancy. Here, our objective was to characterize the effects of WSD and obesity, alone and together, on maternal glucose tolerance and insulin levels in dams during each pregnancy. Recognizing the collinearity of maternal measures, we adjusted for confounding factors including maternal age and parity. Based on intravenous glucose tolerance tests, dams consuming a WSD showed lower glucose area under the curve during first study pregnancies despite increased body fat percentage and increased insulin area under the curve. However, with (1) prolonged WSD feeding, (2) multiple diet switches, and/or (3) increasing age and parity, WSD was associated with increasingly higher insulin levels during glucose tolerance testing, indicative of insulin resistance. Our results suggest that prolonged or recurrent calorically-dense WSD and/or increased parity, rather than obesity per se, drive excess insulin resistance and metabolic dysfunction. These observations in a highly relevant species are likely of clinical and public health importance given the comparative ease of maternal dietary modifications relative to the low likelihood of successfully reversing obesity in the course of any given pregnancy.Joseph M. ElsakrSifang Kathy ZhaoValerie RicciardiTyler A. DeanDiana L. TakahashiElinor SullivanStephanie R. WesolowskiCarrie E. McCurdyPaul KievitJacob E. FriedmanKjersti M. AagaardDigna R. Velez EdwardsMaureen GannonNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Joseph M. Elsakr Sifang Kathy Zhao Valerie Ricciardi Tyler A. Dean Diana L. Takahashi Elinor Sullivan Stephanie R. Wesolowski Carrie E. McCurdy Paul Kievit Jacob E. Friedman Kjersti M. Aagaard Digna R. Velez Edwards Maureen Gannon Western-style diet consumption impairs maternal insulin sensitivity and glucose metabolism during pregnancy in a Japanese macaque model
description	Abstract The prevalence of maternal obesity is increasing in the United States. Offspring born to women with obesity or poor glycemic control have greater odds of becoming obese and developing metabolic disease later in life. Our group has utilized a macaque model to study the metabolic effects of consumption of a calorically-dense, Western-style diet (WSD; 36.3% fat) during pregnancy. Here, our objective was to characterize the effects of WSD and obesity, alone and together, on maternal glucose tolerance and insulin levels in dams during each pregnancy. Recognizing the collinearity of maternal measures, we adjusted for confounding factors including maternal age and parity. Based on intravenous glucose tolerance tests, dams consuming a WSD showed lower glucose area under the curve during first study pregnancies despite increased body fat percentage and increased insulin area under the curve. However, with (1) prolonged WSD feeding, (2) multiple diet switches, and/or (3) increasing age and parity, WSD was associated with increasingly higher insulin levels during glucose tolerance testing, indicative of insulin resistance. Our results suggest that prolonged or recurrent calorically-dense WSD and/or increased parity, rather than obesity per se, drive excess insulin resistance and metabolic dysfunction. These observations in a highly relevant species are likely of clinical and public health importance given the comparative ease of maternal dietary modifications relative to the low likelihood of successfully reversing obesity in the course of any given pregnancy.
format	article
author	Joseph M. Elsakr Sifang Kathy Zhao Valerie Ricciardi Tyler A. Dean Diana L. Takahashi Elinor Sullivan Stephanie R. Wesolowski Carrie E. McCurdy Paul Kievit Jacob E. Friedman Kjersti M. Aagaard Digna R. Velez Edwards Maureen Gannon
author_facet	Joseph M. Elsakr Sifang Kathy Zhao Valerie Ricciardi Tyler A. Dean Diana L. Takahashi Elinor Sullivan Stephanie R. Wesolowski Carrie E. McCurdy Paul Kievit Jacob E. Friedman Kjersti M. Aagaard Digna R. Velez Edwards Maureen Gannon
author_sort	Joseph M. Elsakr
title	Western-style diet consumption impairs maternal insulin sensitivity and glucose metabolism during pregnancy in a Japanese macaque model
title_short	Western-style diet consumption impairs maternal insulin sensitivity and glucose metabolism during pregnancy in a Japanese macaque model
title_full	Western-style diet consumption impairs maternal insulin sensitivity and glucose metabolism during pregnancy in a Japanese macaque model
title_fullStr	Western-style diet consumption impairs maternal insulin sensitivity and glucose metabolism during pregnancy in a Japanese macaque model
title_full_unstemmed	Western-style diet consumption impairs maternal insulin sensitivity and glucose metabolism during pregnancy in a Japanese macaque model
title_sort	western-style diet consumption impairs maternal insulin sensitivity and glucose metabolism during pregnancy in a japanese macaque model
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/aa19a82e9f5149fe9535985f2027cb5b
work_keys_str_mv	AT josephmelsakr westernstyledietconsumptionimpairsmaternalinsulinsensitivityandglucosemetabolismduringpregnancyinajapanesemacaquemodel AT sifangkathyzhao westernstyledietconsumptionimpairsmaternalinsulinsensitivityandglucosemetabolismduringpregnancyinajapanesemacaquemodel AT valeriericciardi westernstyledietconsumptionimpairsmaternalinsulinsensitivityandglucosemetabolismduringpregnancyinajapanesemacaquemodel AT tyleradean westernstyledietconsumptionimpairsmaternalinsulinsensitivityandglucosemetabolismduringpregnancyinajapanesemacaquemodel AT dianaltakahashi westernstyledietconsumptionimpairsmaternalinsulinsensitivityandglucosemetabolismduringpregnancyinajapanesemacaquemodel AT elinorsullivan westernstyledietconsumptionimpairsmaternalinsulinsensitivityandglucosemetabolismduringpregnancyinajapanesemacaquemodel AT stephanierwesolowski westernstyledietconsumptionimpairsmaternalinsulinsensitivityandglucosemetabolismduringpregnancyinajapanesemacaquemodel AT carrieemccurdy westernstyledietconsumptionimpairsmaternalinsulinsensitivityandglucosemetabolismduringpregnancyinajapanesemacaquemodel AT paulkievit westernstyledietconsumptionimpairsmaternalinsulinsensitivityandglucosemetabolismduringpregnancyinajapanesemacaquemodel AT jacobefriedman westernstyledietconsumptionimpairsmaternalinsulinsensitivityandglucosemetabolismduringpregnancyinajapanesemacaquemodel AT kjerstimaagaard westernstyledietconsumptionimpairsmaternalinsulinsensitivityandglucosemetabolismduringpregnancyinajapanesemacaquemodel AT dignarvelezedwards westernstyledietconsumptionimpairsmaternalinsulinsensitivityandglucosemetabolismduringpregnancyinajapanesemacaquemodel AT maureengannon westernstyledietconsumptionimpairsmaternalinsulinsensitivityandglucosemetabolismduringpregnancyinajapanesemacaquemodel
_version_	1718384797516038144

Western-style diet consumption impairs maternal insulin sensitivity and glucose metabolism during pregnancy in a Japanese macaque model

Ejemplares similares