Stability and function of adult vasculature is sustained by Akt/Jagged1 signalling axis in endothelium

The Akt pathway integrates multiple signals, but whether it affects vasculature function is debatable. Here the authors show that Akt pathway shutdown in adult mouse endothelium causes destabilization of vasculature leading to cardiac and retinal dysfunction, due to decreased levels of Jagged1 and i...

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Autores principales: Bethany A. Kerr, Xiaoxia Z. West, Young-Woong Kim, Yongzhong Zhao, Miroslava Tischenko, Rebecca M. Cull, Timothy W. Phares, Xiao-Ding Peng, Jeremiah Bernier-Latmani, Tatiana V. Petrova, Ralf H. Adams, Nissim Hay, Sathyamangla V. Naga Prasad, Tatiana V. Byzova
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/aa2930f6d9ad490f80a89a4237983af6
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spelling oai:doaj.org-article:aa2930f6d9ad490f80a89a4237983af62021-12-02T14:38:35ZStability and function of adult vasculature is sustained by Akt/Jagged1 signalling axis in endothelium10.1038/ncomms109602041-1723https://doaj.org/article/aa2930f6d9ad490f80a89a4237983af62016-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms10960https://doaj.org/toc/2041-1723The Akt pathway integrates multiple signals, but whether it affects vasculature function is debatable. Here the authors show that Akt pathway shutdown in adult mouse endothelium causes destabilization of vasculature leading to cardiac and retinal dysfunction, due to decreased levels of Jagged1 and impaired Notch signaling.Bethany A. KerrXiaoxia Z. WestYoung-Woong KimYongzhong ZhaoMiroslava TischenkoRebecca M. CullTimothy W. PharesXiao-Ding PengJeremiah Bernier-LatmaniTatiana V. PetrovaRalf H. AdamsNissim HaySathyamangla V. Naga PrasadTatiana V. ByzovaNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-18 (2016)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Bethany A. Kerr
Xiaoxia Z. West
Young-Woong Kim
Yongzhong Zhao
Miroslava Tischenko
Rebecca M. Cull
Timothy W. Phares
Xiao-Ding Peng
Jeremiah Bernier-Latmani
Tatiana V. Petrova
Ralf H. Adams
Nissim Hay
Sathyamangla V. Naga Prasad
Tatiana V. Byzova
Stability and function of adult vasculature is sustained by Akt/Jagged1 signalling axis in endothelium
description The Akt pathway integrates multiple signals, but whether it affects vasculature function is debatable. Here the authors show that Akt pathway shutdown in adult mouse endothelium causes destabilization of vasculature leading to cardiac and retinal dysfunction, due to decreased levels of Jagged1 and impaired Notch signaling.
format article
author Bethany A. Kerr
Xiaoxia Z. West
Young-Woong Kim
Yongzhong Zhao
Miroslava Tischenko
Rebecca M. Cull
Timothy W. Phares
Xiao-Ding Peng
Jeremiah Bernier-Latmani
Tatiana V. Petrova
Ralf H. Adams
Nissim Hay
Sathyamangla V. Naga Prasad
Tatiana V. Byzova
author_facet Bethany A. Kerr
Xiaoxia Z. West
Young-Woong Kim
Yongzhong Zhao
Miroslava Tischenko
Rebecca M. Cull
Timothy W. Phares
Xiao-Ding Peng
Jeremiah Bernier-Latmani
Tatiana V. Petrova
Ralf H. Adams
Nissim Hay
Sathyamangla V. Naga Prasad
Tatiana V. Byzova
author_sort Bethany A. Kerr
title Stability and function of adult vasculature is sustained by Akt/Jagged1 signalling axis in endothelium
title_short Stability and function of adult vasculature is sustained by Akt/Jagged1 signalling axis in endothelium
title_full Stability and function of adult vasculature is sustained by Akt/Jagged1 signalling axis in endothelium
title_fullStr Stability and function of adult vasculature is sustained by Akt/Jagged1 signalling axis in endothelium
title_full_unstemmed Stability and function of adult vasculature is sustained by Akt/Jagged1 signalling axis in endothelium
title_sort stability and function of adult vasculature is sustained by akt/jagged1 signalling axis in endothelium
publisher Nature Portfolio
publishDate 2016
url https://doaj.org/article/aa2930f6d9ad490f80a89a4237983af6
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