Stability and function of adult vasculature is sustained by Akt/Jagged1 signalling axis in endothelium
The Akt pathway integrates multiple signals, but whether it affects vasculature function is debatable. Here the authors show that Akt pathway shutdown in adult mouse endothelium causes destabilization of vasculature leading to cardiac and retinal dysfunction, due to decreased levels of Jagged1 and i...
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Nature Portfolio
2016
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oai:doaj.org-article:aa2930f6d9ad490f80a89a4237983af62021-12-02T14:38:35ZStability and function of adult vasculature is sustained by Akt/Jagged1 signalling axis in endothelium10.1038/ncomms109602041-1723https://doaj.org/article/aa2930f6d9ad490f80a89a4237983af62016-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms10960https://doaj.org/toc/2041-1723The Akt pathway integrates multiple signals, but whether it affects vasculature function is debatable. Here the authors show that Akt pathway shutdown in adult mouse endothelium causes destabilization of vasculature leading to cardiac and retinal dysfunction, due to decreased levels of Jagged1 and impaired Notch signaling.Bethany A. KerrXiaoxia Z. WestYoung-Woong KimYongzhong ZhaoMiroslava TischenkoRebecca M. CullTimothy W. PharesXiao-Ding PengJeremiah Bernier-LatmaniTatiana V. PetrovaRalf H. AdamsNissim HaySathyamangla V. Naga PrasadTatiana V. ByzovaNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-18 (2016) |
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Science Q Bethany A. Kerr Xiaoxia Z. West Young-Woong Kim Yongzhong Zhao Miroslava Tischenko Rebecca M. Cull Timothy W. Phares Xiao-Ding Peng Jeremiah Bernier-Latmani Tatiana V. Petrova Ralf H. Adams Nissim Hay Sathyamangla V. Naga Prasad Tatiana V. Byzova Stability and function of adult vasculature is sustained by Akt/Jagged1 signalling axis in endothelium |
description |
The Akt pathway integrates multiple signals, but whether it affects vasculature function is debatable. Here the authors show that Akt pathway shutdown in adult mouse endothelium causes destabilization of vasculature leading to cardiac and retinal dysfunction, due to decreased levels of Jagged1 and impaired Notch signaling. |
format |
article |
author |
Bethany A. Kerr Xiaoxia Z. West Young-Woong Kim Yongzhong Zhao Miroslava Tischenko Rebecca M. Cull Timothy W. Phares Xiao-Ding Peng Jeremiah Bernier-Latmani Tatiana V. Petrova Ralf H. Adams Nissim Hay Sathyamangla V. Naga Prasad Tatiana V. Byzova |
author_facet |
Bethany A. Kerr Xiaoxia Z. West Young-Woong Kim Yongzhong Zhao Miroslava Tischenko Rebecca M. Cull Timothy W. Phares Xiao-Ding Peng Jeremiah Bernier-Latmani Tatiana V. Petrova Ralf H. Adams Nissim Hay Sathyamangla V. Naga Prasad Tatiana V. Byzova |
author_sort |
Bethany A. Kerr |
title |
Stability and function of adult vasculature is sustained by Akt/Jagged1 signalling axis in endothelium |
title_short |
Stability and function of adult vasculature is sustained by Akt/Jagged1 signalling axis in endothelium |
title_full |
Stability and function of adult vasculature is sustained by Akt/Jagged1 signalling axis in endothelium |
title_fullStr |
Stability and function of adult vasculature is sustained by Akt/Jagged1 signalling axis in endothelium |
title_full_unstemmed |
Stability and function of adult vasculature is sustained by Akt/Jagged1 signalling axis in endothelium |
title_sort |
stability and function of adult vasculature is sustained by akt/jagged1 signalling axis in endothelium |
publisher |
Nature Portfolio |
publishDate |
2016 |
url |
https://doaj.org/article/aa2930f6d9ad490f80a89a4237983af6 |
work_keys_str_mv |
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