Stability and function of adult vasculature is sustained by Akt/Jagged1 signalling axis in endothelium

The Akt pathway integrates multiple signals, but whether it affects vasculature function is debatable. Here the authors show that Akt pathway shutdown in adult mouse endothelium causes destabilization of vasculature leading to cardiac and retinal dysfunction, due to decreased levels of Jagged1 and i...

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Main Authors:	Bethany A. Kerr, Xiaoxia Z. West, Young-Woong Kim, Yongzhong Zhao, Miroslava Tischenko, Rebecca M. Cull, Timothy W. Phares, Xiao-Ding Peng, Jeremiah Bernier-Latmani, Tatiana V. Petrova, Ralf H. Adams, Nissim Hay, Sathyamangla V. Naga Prasad, Tatiana V. Byzova
Format:	article
Language:	EN
Published:	Nature Portfolio 2016
Subjects:	Science Q
Online Access:	https://doaj.org/article/aa2930f6d9ad490f80a89a4237983af6
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spelling	oai:doaj.org-article:aa2930f6d9ad490f80a89a4237983af62021-12-02T14:38:35ZStability and function of adult vasculature is sustained by Akt/Jagged1 signalling axis in endothelium10.1038/ncomms109602041-1723https://doaj.org/article/aa2930f6d9ad490f80a89a4237983af62016-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms10960https://doaj.org/toc/2041-1723The Akt pathway integrates multiple signals, but whether it affects vasculature function is debatable. Here the authors show that Akt pathway shutdown in adult mouse endothelium causes destabilization of vasculature leading to cardiac and retinal dysfunction, due to decreased levels of Jagged1 and impaired Notch signaling.Bethany A. KerrXiaoxia Z. WestYoung-Woong KimYongzhong ZhaoMiroslava TischenkoRebecca M. CullTimothy W. PharesXiao-Ding PengJeremiah Bernier-LatmaniTatiana V. PetrovaRalf H. AdamsNissim HaySathyamangla V. Naga PrasadTatiana V. ByzovaNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-18 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Bethany A. Kerr Xiaoxia Z. West Young-Woong Kim Yongzhong Zhao Miroslava Tischenko Rebecca M. Cull Timothy W. Phares Xiao-Ding Peng Jeremiah Bernier-Latmani Tatiana V. Petrova Ralf H. Adams Nissim Hay Sathyamangla V. Naga Prasad Tatiana V. Byzova Stability and function of adult vasculature is sustained by Akt/Jagged1 signalling axis in endothelium
description	The Akt pathway integrates multiple signals, but whether it affects vasculature function is debatable. Here the authors show that Akt pathway shutdown in adult mouse endothelium causes destabilization of vasculature leading to cardiac and retinal dysfunction, due to decreased levels of Jagged1 and impaired Notch signaling.
format	article
author	Bethany A. Kerr Xiaoxia Z. West Young-Woong Kim Yongzhong Zhao Miroslava Tischenko Rebecca M. Cull Timothy W. Phares Xiao-Ding Peng Jeremiah Bernier-Latmani Tatiana V. Petrova Ralf H. Adams Nissim Hay Sathyamangla V. Naga Prasad Tatiana V. Byzova
author_facet	Bethany A. Kerr Xiaoxia Z. West Young-Woong Kim Yongzhong Zhao Miroslava Tischenko Rebecca M. Cull Timothy W. Phares Xiao-Ding Peng Jeremiah Bernier-Latmani Tatiana V. Petrova Ralf H. Adams Nissim Hay Sathyamangla V. Naga Prasad Tatiana V. Byzova
author_sort	Bethany A. Kerr
title	Stability and function of adult vasculature is sustained by Akt/Jagged1 signalling axis in endothelium
title_short	Stability and function of adult vasculature is sustained by Akt/Jagged1 signalling axis in endothelium
title_full	Stability and function of adult vasculature is sustained by Akt/Jagged1 signalling axis in endothelium
title_fullStr	Stability and function of adult vasculature is sustained by Akt/Jagged1 signalling axis in endothelium
title_full_unstemmed	Stability and function of adult vasculature is sustained by Akt/Jagged1 signalling axis in endothelium
title_sort	stability and function of adult vasculature is sustained by akt/jagged1 signalling axis in endothelium
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/aa2930f6d9ad490f80a89a4237983af6
work_keys_str_mv	AT bethanyakerr stabilityandfunctionofadultvasculatureissustainedbyaktjagged1signallingaxisinendothelium AT xiaoxiazwest stabilityandfunctionofadultvasculatureissustainedbyaktjagged1signallingaxisinendothelium AT youngwoongkim stabilityandfunctionofadultvasculatureissustainedbyaktjagged1signallingaxisinendothelium AT yongzhongzhao stabilityandfunctionofadultvasculatureissustainedbyaktjagged1signallingaxisinendothelium AT miroslavatischenko stabilityandfunctionofadultvasculatureissustainedbyaktjagged1signallingaxisinendothelium AT rebeccamcull stabilityandfunctionofadultvasculatureissustainedbyaktjagged1signallingaxisinendothelium AT timothywphares stabilityandfunctionofadultvasculatureissustainedbyaktjagged1signallingaxisinendothelium AT xiaodingpeng stabilityandfunctionofadultvasculatureissustainedbyaktjagged1signallingaxisinendothelium AT jeremiahbernierlatmani stabilityandfunctionofadultvasculatureissustainedbyaktjagged1signallingaxisinendothelium AT tatianavpetrova stabilityandfunctionofadultvasculatureissustainedbyaktjagged1signallingaxisinendothelium AT ralfhadams stabilityandfunctionofadultvasculatureissustainedbyaktjagged1signallingaxisinendothelium AT nissimhay stabilityandfunctionofadultvasculatureissustainedbyaktjagged1signallingaxisinendothelium AT sathyamanglavnagaprasad stabilityandfunctionofadultvasculatureissustainedbyaktjagged1signallingaxisinendothelium AT tatianavbyzova stabilityandfunctionofadultvasculatureissustainedbyaktjagged1signallingaxisinendothelium
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Stability and function of adult vasculature is sustained by Akt/Jagged1 signalling axis in endothelium

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