CHARACTERISTICS OF CYTOKINE PROFILE LEVEL (TNFα, IL-6, IL-10) AND THEIR SOLUBLE RECEPTORS (SRр55 TNFα, SRр75 TNFα, SR IL-6) IN THE PATIENTS WITH HIV, HIV-ASSOCIATED TUBERCULOSIS AND PULMONARY TUBERCULOSIS

Abstract. Three groups of patients were investigated as follows: 1st group, HIV-infected patients, 2nd group, patients with HIV-associated tuberculosis, the 3rd group, persons with pulmonary tuberculosis. The amounts of cytokines (TNFα, IL-6, IL-10) and their soluble receptors (SRp55 TNFα, SRp75 TNF...

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Autores principales:	E. V. Markelova, S. A. Sotnichenko, L. F. Sklyar, A. E. Safronov
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	cytokines soluble cytokines receptors hiv-infected patients hiv-associated tuberculosis Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/aa2b3729efb24627bfb1f5203f3330e4
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spelling	oai:doaj.org-article:aa2b3729efb24627bfb1f5203f3330e42021-11-18T08:03:39ZCHARACTERISTICS OF CYTOKINE PROFILE LEVEL (TNFα, IL-6, IL-10) AND THEIR SOLUBLE RECEPTORS (SRр55 TNFα, SRр75 TNFα, SR IL-6) IN THE PATIENTS WITH HIV, HIV-ASSOCIATED TUBERCULOSIS AND PULMONARY TUBERCULOSIS1563-06252313-741X10.15789/1563-0625-2008-6-519-526https://doaj.org/article/aa2b3729efb24627bfb1f5203f3330e42014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/257https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. Three groups of patients were investigated as follows: 1st group, HIV-infected patients, 2nd group, patients with HIV-associated tuberculosis, the 3rd group, persons with pulmonary tuberculosis. The amounts of cytokines (TNFα, IL-6, IL-10) and their soluble receptors (SRp55 TNFα, SRp75 TNFα, SR IL-6) were evaluated in blood serum by solid-phase immuno-enzyme technique. The patients did not receive antiviral therapy before, or during the investigations. Some features are revealed reflecting a direction and significance of changes in immune reactivity of the patients. In the patients with tuberculosis, IL-10 and IL-6 levels were increased, along with pronounced rise of srIL-6, relatively low index of SRp75 TNFα and deficiency of SRp55 TNFα, associated with moderate increase in TNFα. In the patients with HIV and HIV-associated tuberculosis, the direction of alterations were found to be similar, except of IL-10, i.e., a hyper-production of TNFα and its soluble type I and II receptors, increased IL-6 level in combination with lack of its soluble receptor. Correlation analysis showed a strict dependence between TNFα and viral load in the patients with IVB and V stage of HIV, and HIV-associated tuberculosis that argues for significance of TNFα in pathogenesis of HIV-infection and its progression. We have found differential trends in dynamics of cytokines under study and their soluble receptors in the course of HIV-infection progression in the groups I and II of patients, that allowing us of elaborating additional diagnostic criteria of HIV-associated tuberculosis. (Med. Immunol., vol. 10, N 6, pp 519-526).E. V. MarkelovaS. A. SotnichenkoL. F. SklyarA. E. SafronovSPb RAACIarticlecytokinessoluble cytokines receptorshiv-infected patientshiv-associated tuberculosisImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 10, Iss 6, Pp 519-526 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	cytokines soluble cytokines receptors hiv-infected patients hiv-associated tuberculosis Immunologic diseases. Allergy RC581-607
spellingShingle	cytokines soluble cytokines receptors hiv-infected patients hiv-associated tuberculosis Immunologic diseases. Allergy RC581-607 E. V. Markelova S. A. Sotnichenko L. F. Sklyar A. E. Safronov CHARACTERISTICS OF CYTOKINE PROFILE LEVEL (TNFα, IL-6, IL-10) AND THEIR SOLUBLE RECEPTORS (SRр55 TNFα, SRр75 TNFα, SR IL-6) IN THE PATIENTS WITH HIV, HIV-ASSOCIATED TUBERCULOSIS AND PULMONARY TUBERCULOSIS
description	Abstract. Three groups of patients were investigated as follows: 1st group, HIV-infected patients, 2nd group, patients with HIV-associated tuberculosis, the 3rd group, persons with pulmonary tuberculosis. The amounts of cytokines (TNFα, IL-6, IL-10) and their soluble receptors (SRp55 TNFα, SRp75 TNFα, SR IL-6) were evaluated in blood serum by solid-phase immuno-enzyme technique. The patients did not receive antiviral therapy before, or during the investigations. Some features are revealed reflecting a direction and significance of changes in immune reactivity of the patients. In the patients with tuberculosis, IL-10 and IL-6 levels were increased, along with pronounced rise of srIL-6, relatively low index of SRp75 TNFα and deficiency of SRp55 TNFα, associated with moderate increase in TNFα. In the patients with HIV and HIV-associated tuberculosis, the direction of alterations were found to be similar, except of IL-10, i.e., a hyper-production of TNFα and its soluble type I and II receptors, increased IL-6 level in combination with lack of its soluble receptor. Correlation analysis showed a strict dependence between TNFα and viral load in the patients with IVB and V stage of HIV, and HIV-associated tuberculosis that argues for significance of TNFα in pathogenesis of HIV-infection and its progression. We have found differential trends in dynamics of cytokines under study and their soluble receptors in the course of HIV-infection progression in the groups I and II of patients, that allowing us of elaborating additional diagnostic criteria of HIV-associated tuberculosis. (Med. Immunol., vol. 10, N 6, pp 519-526).
format	article
author	E. V. Markelova S. A. Sotnichenko L. F. Sklyar A. E. Safronov
author_facet	E. V. Markelova S. A. Sotnichenko L. F. Sklyar A. E. Safronov
author_sort	E. V. Markelova
title	CHARACTERISTICS OF CYTOKINE PROFILE LEVEL (TNFα, IL-6, IL-10) AND THEIR SOLUBLE RECEPTORS (SRр55 TNFα, SRр75 TNFα, SR IL-6) IN THE PATIENTS WITH HIV, HIV-ASSOCIATED TUBERCULOSIS AND PULMONARY TUBERCULOSIS
title_short	CHARACTERISTICS OF CYTOKINE PROFILE LEVEL (TNFα, IL-6, IL-10) AND THEIR SOLUBLE RECEPTORS (SRр55 TNFα, SRр75 TNFα, SR IL-6) IN THE PATIENTS WITH HIV, HIV-ASSOCIATED TUBERCULOSIS AND PULMONARY TUBERCULOSIS
title_full	CHARACTERISTICS OF CYTOKINE PROFILE LEVEL (TNFα, IL-6, IL-10) AND THEIR SOLUBLE RECEPTORS (SRр55 TNFα, SRр75 TNFα, SR IL-6) IN THE PATIENTS WITH HIV, HIV-ASSOCIATED TUBERCULOSIS AND PULMONARY TUBERCULOSIS
title_fullStr	CHARACTERISTICS OF CYTOKINE PROFILE LEVEL (TNFα, IL-6, IL-10) AND THEIR SOLUBLE RECEPTORS (SRр55 TNFα, SRр75 TNFα, SR IL-6) IN THE PATIENTS WITH HIV, HIV-ASSOCIATED TUBERCULOSIS AND PULMONARY TUBERCULOSIS
title_full_unstemmed	CHARACTERISTICS OF CYTOKINE PROFILE LEVEL (TNFα, IL-6, IL-10) AND THEIR SOLUBLE RECEPTORS (SRр55 TNFα, SRр75 TNFα, SR IL-6) IN THE PATIENTS WITH HIV, HIV-ASSOCIATED TUBERCULOSIS AND PULMONARY TUBERCULOSIS
title_sort	characteristics of cytokine profile level (tnfα, il-6, il-10) and their soluble receptors (srр55 tnfα, srр75 tnfα, sr il-6) in the patients with hiv, hiv-associated tuberculosis and pulmonary tuberculosis
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/aa2b3729efb24627bfb1f5203f3330e4
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CHARACTERISTICS OF CYTOKINE PROFILE LEVEL (TNFα, IL-6, IL-10) AND THEIR SOLUBLE RECEPTORS (SRр55 TNFα, SRр75 TNFα, SR IL-6) IN THE PATIENTS WITH HIV, HIV-ASSOCIATED TUBERCULOSIS AND PULMONARY TUBERCULOSIS

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