Reduction of Derlin activity suppresses Notch-dependent tumours in the C. elegans germ line.

Regulating the balance between self-renewal (proliferation) and differentiation is key to the long-term functioning of all stem cell pools. In the Caenorhabditis elegans germline, the primary signal controlling this balance is the conserved Notch signaling pathway. Gain-of-function mutations in the...

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Bibliographic Details
Main Authors: Ramya Singh, Ryan B Smit, Xin Wang, Chris Wang, Hilary Racher, Dave Hansen
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2021
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Online Access:https://doaj.org/article/aa2dd44ee7fb48f49da522b91b00bc1a
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