A systematic review and meta-analysis of regional risk factors for critical outcomes of COVID-19 during early phase of the pandemic

Abstract The mortality rates of COVID-19 vary across the globe. While some risk factors for poor prognosis of the disease are known, regional differences are suspected. We reviewed the risk factors for critical outcomes of COVID-19 according to the location of the infected patients, from various lit...

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Autores principales:	Hyung-Jun Kim, Hyeontaek Hwang, Hyunsook Hong, Jae-Joon Yim, Jinwoo Lee
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/aa32ea93317e41afbfaf915217aa16bd
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spelling	oai:doaj.org-article:aa32ea93317e41afbfaf915217aa16bd2021-12-02T14:49:33ZA systematic review and meta-analysis of regional risk factors for critical outcomes of COVID-19 during early phase of the pandemic10.1038/s41598-021-89182-82045-2322https://doaj.org/article/aa32ea93317e41afbfaf915217aa16bd2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-89182-8https://doaj.org/toc/2045-2322Abstract The mortality rates of COVID-19 vary across the globe. While some risk factors for poor prognosis of the disease are known, regional differences are suspected. We reviewed the risk factors for critical outcomes of COVID-19 according to the location of the infected patients, from various literature databases from January 1 through June 8, 2020. Candidate variables to predict the outcome included patient demographics, underlying medical conditions, symptoms, and laboratory findings. The risk factors in the overall population included sex, age, and all inspected underlying medical conditions. Symptoms of dyspnea, anorexia, dizziness, fatigue, and certain laboratory findings were also indicators of the critical outcome. Underlying respiratory disease was associated higher risk of the critical outcome in studies from Asia and Europe, but not North America. Underlying hepatic disease was associated with a higher risk of the critical outcome from Europe, but not from Asia and North America. Symptoms of vomiting, anorexia, dizziness, and fatigue were significantly associated with the critical outcome in studies from Asia, but not from Europe and North America. Hemoglobin and platelet count affected patients differently in Asia compared to those in Europe and North America. Such regional discrepancies should be considered when treating patients with COVID-19.Hyung-Jun KimHyeontaek HwangHyunsook HongJae-Joon YimJinwoo LeeNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hyung-Jun Kim Hyeontaek Hwang Hyunsook Hong Jae-Joon Yim Jinwoo Lee A systematic review and meta-analysis of regional risk factors for critical outcomes of COVID-19 during early phase of the pandemic
description	Abstract The mortality rates of COVID-19 vary across the globe. While some risk factors for poor prognosis of the disease are known, regional differences are suspected. We reviewed the risk factors for critical outcomes of COVID-19 according to the location of the infected patients, from various literature databases from January 1 through June 8, 2020. Candidate variables to predict the outcome included patient demographics, underlying medical conditions, symptoms, and laboratory findings. The risk factors in the overall population included sex, age, and all inspected underlying medical conditions. Symptoms of dyspnea, anorexia, dizziness, fatigue, and certain laboratory findings were also indicators of the critical outcome. Underlying respiratory disease was associated higher risk of the critical outcome in studies from Asia and Europe, but not North America. Underlying hepatic disease was associated with a higher risk of the critical outcome from Europe, but not from Asia and North America. Symptoms of vomiting, anorexia, dizziness, and fatigue were significantly associated with the critical outcome in studies from Asia, but not from Europe and North America. Hemoglobin and platelet count affected patients differently in Asia compared to those in Europe and North America. Such regional discrepancies should be considered when treating patients with COVID-19.
format	article
author	Hyung-Jun Kim Hyeontaek Hwang Hyunsook Hong Jae-Joon Yim Jinwoo Lee
author_facet	Hyung-Jun Kim Hyeontaek Hwang Hyunsook Hong Jae-Joon Yim Jinwoo Lee
author_sort	Hyung-Jun Kim
title	A systematic review and meta-analysis of regional risk factors for critical outcomes of COVID-19 during early phase of the pandemic
title_short	A systematic review and meta-analysis of regional risk factors for critical outcomes of COVID-19 during early phase of the pandemic
title_full	A systematic review and meta-analysis of regional risk factors for critical outcomes of COVID-19 during early phase of the pandemic
title_fullStr	A systematic review and meta-analysis of regional risk factors for critical outcomes of COVID-19 during early phase of the pandemic
title_full_unstemmed	A systematic review and meta-analysis of regional risk factors for critical outcomes of COVID-19 during early phase of the pandemic
title_sort	systematic review and meta-analysis of regional risk factors for critical outcomes of covid-19 during early phase of the pandemic
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/aa32ea93317e41afbfaf915217aa16bd
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A systematic review and meta-analysis of regional risk factors for critical outcomes of COVID-19 during early phase of the pandemic

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