Quantifying the influence of mutation detection on tumour subclonal reconstruction

The impact of variant calling algorithms on the analysis of intra-tumour heterogeneity has not been properly quantified. Here the authors measure the variability of 22 pipelines with different variant callers and clustering algorithms for subclonal reconstruction to inform future analyses.

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Auteurs principaux:	Lydia Y. Liu, Vinayak Bhandari, Adriana Salcedo, Shadrielle M. G. Espiritu, Quaid D. Morris, Thomas Kislinger, Paul C. Boutros
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2020
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/aa348a33ae6a40059a2acc59be8bbea2
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spelling	oai:doaj.org-article:aa348a33ae6a40059a2acc59be8bbea22021-12-02T13:24:24ZQuantifying the influence of mutation detection on tumour subclonal reconstruction10.1038/s41467-020-20055-w2041-1723https://doaj.org/article/aa348a33ae6a40059a2acc59be8bbea22020-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20055-whttps://doaj.org/toc/2041-1723The impact of variant calling algorithms on the analysis of intra-tumour heterogeneity has not been properly quantified. Here the authors measure the variability of 22 pipelines with different variant callers and clustering algorithms for subclonal reconstruction to inform future analyses.Lydia Y. LiuVinayak BhandariAdriana SalcedoShadrielle M. G. EspirituQuaid D. MorrisThomas KislingerPaul C. BoutrosNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Lydia Y. Liu Vinayak Bhandari Adriana Salcedo Shadrielle M. G. Espiritu Quaid D. Morris Thomas Kislinger Paul C. Boutros Quantifying the influence of mutation detection on tumour subclonal reconstruction
description	The impact of variant calling algorithms on the analysis of intra-tumour heterogeneity has not been properly quantified. Here the authors measure the variability of 22 pipelines with different variant callers and clustering algorithms for subclonal reconstruction to inform future analyses.
format	article
author	Lydia Y. Liu Vinayak Bhandari Adriana Salcedo Shadrielle M. G. Espiritu Quaid D. Morris Thomas Kislinger Paul C. Boutros
author_facet	Lydia Y. Liu Vinayak Bhandari Adriana Salcedo Shadrielle M. G. Espiritu Quaid D. Morris Thomas Kislinger Paul C. Boutros
author_sort	Lydia Y. Liu
title	Quantifying the influence of mutation detection on tumour subclonal reconstruction
title_short	Quantifying the influence of mutation detection on tumour subclonal reconstruction
title_full	Quantifying the influence of mutation detection on tumour subclonal reconstruction
title_fullStr	Quantifying the influence of mutation detection on tumour subclonal reconstruction
title_full_unstemmed	Quantifying the influence of mutation detection on tumour subclonal reconstruction
title_sort	quantifying the influence of mutation detection on tumour subclonal reconstruction
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/aa348a33ae6a40059a2acc59be8bbea2
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Quantifying the influence of mutation detection on tumour subclonal reconstruction

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