Comparative transcriptome analyses indicate molecular homology of zebrafish swimbladder and mammalian lung.

The fish swimbladder is a unique organ in vertebrate evolution and it functions for regulating buoyancy in most teleost species. It has long been postulated as a homolog of the tetrapod lung, but the molecular evidence is scarce. In order to understand the molecular function of swimbladder as well a...

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Autores principales:	Weiling Zheng, Zhengyuan Wang, John E Collins, Robert M Andrews, Derek Stemple, Zhiyuan Gong
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/aa36e23c0a9a48f5aaae0bbc906daabd
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spelling	oai:doaj.org-article:aa36e23c0a9a48f5aaae0bbc906daabd2021-11-18T06:47:10ZComparative transcriptome analyses indicate molecular homology of zebrafish swimbladder and mammalian lung.1932-620310.1371/journal.pone.0024019https://doaj.org/article/aa36e23c0a9a48f5aaae0bbc906daabd2011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21887364/?tool=EBIhttps://doaj.org/toc/1932-6203The fish swimbladder is a unique organ in vertebrate evolution and it functions for regulating buoyancy in most teleost species. It has long been postulated as a homolog of the tetrapod lung, but the molecular evidence is scarce. In order to understand the molecular function of swimbladder as well as its relationship with lungs in tetrapods, transcriptomic analyses of zebrafish swimbladder were carried out by RNA-seq. Gene ontology classification showed that genes in cytoskeleton and endoplasmic reticulum were enriched in the swimbladder. Further analyses depicted gene sets and pathways closely related to cytoskeleton constitution and regulation, cell adhesion, and extracellular matrix. Several prominent transcription factor genes in the swimbladder including hoxc4a, hoxc6a, hoxc8a and foxf1 were identified and their expressions in developing swimbladder during embryogenesis were confirmed. By comparison of enriched transcripts in the swimbladder with those in human and mouse lungs, we established the resemblance of transcriptome of the zebrafish swimbladder and mammalian lungs. Based on the transcriptomic data of zebrafish swimbladder, the predominant functions of swimbladder are in its epithelial and muscular tissues. Our comparative analyses also provide molecular evidence of the relatedness of the fish swimbladder and mammalian lung.Weiling ZhengZhengyuan WangJohn E CollinsRobert M AndrewsDerek StempleZhiyuan GongPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 8, p e24019 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Weiling Zheng Zhengyuan Wang John E Collins Robert M Andrews Derek Stemple Zhiyuan Gong Comparative transcriptome analyses indicate molecular homology of zebrafish swimbladder and mammalian lung.
description	The fish swimbladder is a unique organ in vertebrate evolution and it functions for regulating buoyancy in most teleost species. It has long been postulated as a homolog of the tetrapod lung, but the molecular evidence is scarce. In order to understand the molecular function of swimbladder as well as its relationship with lungs in tetrapods, transcriptomic analyses of zebrafish swimbladder were carried out by RNA-seq. Gene ontology classification showed that genes in cytoskeleton and endoplasmic reticulum were enriched in the swimbladder. Further analyses depicted gene sets and pathways closely related to cytoskeleton constitution and regulation, cell adhesion, and extracellular matrix. Several prominent transcription factor genes in the swimbladder including hoxc4a, hoxc6a, hoxc8a and foxf1 were identified and their expressions in developing swimbladder during embryogenesis were confirmed. By comparison of enriched transcripts in the swimbladder with those in human and mouse lungs, we established the resemblance of transcriptome of the zebrafish swimbladder and mammalian lungs. Based on the transcriptomic data of zebrafish swimbladder, the predominant functions of swimbladder are in its epithelial and muscular tissues. Our comparative analyses also provide molecular evidence of the relatedness of the fish swimbladder and mammalian lung.
format	article
author	Weiling Zheng Zhengyuan Wang John E Collins Robert M Andrews Derek Stemple Zhiyuan Gong
author_facet	Weiling Zheng Zhengyuan Wang John E Collins Robert M Andrews Derek Stemple Zhiyuan Gong
author_sort	Weiling Zheng
title	Comparative transcriptome analyses indicate molecular homology of zebrafish swimbladder and mammalian lung.
title_short	Comparative transcriptome analyses indicate molecular homology of zebrafish swimbladder and mammalian lung.
title_full	Comparative transcriptome analyses indicate molecular homology of zebrafish swimbladder and mammalian lung.
title_fullStr	Comparative transcriptome analyses indicate molecular homology of zebrafish swimbladder and mammalian lung.
title_full_unstemmed	Comparative transcriptome analyses indicate molecular homology of zebrafish swimbladder and mammalian lung.
title_sort	comparative transcriptome analyses indicate molecular homology of zebrafish swimbladder and mammalian lung.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/aa36e23c0a9a48f5aaae0bbc906daabd
work_keys_str_mv	AT weilingzheng comparativetranscriptomeanalysesindicatemolecularhomologyofzebrafishswimbladderandmammalianlung AT zhengyuanwang comparativetranscriptomeanalysesindicatemolecularhomologyofzebrafishswimbladderandmammalianlung AT johnecollins comparativetranscriptomeanalysesindicatemolecularhomologyofzebrafishswimbladderandmammalianlung AT robertmandrews comparativetranscriptomeanalysesindicatemolecularhomologyofzebrafishswimbladderandmammalianlung AT derekstemple comparativetranscriptomeanalysesindicatemolecularhomologyofzebrafishswimbladderandmammalianlung AT zhiyuangong comparativetranscriptomeanalysesindicatemolecularhomologyofzebrafishswimbladderandmammalianlung
_version_	1718424435679035392

Comparative transcriptome analyses indicate molecular homology of zebrafish swimbladder and mammalian lung.

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