Effect of gestational age and postnatal age on the endothelial glycocalyx in neonates

Abstract Prematurity predisposes to cardiovascular disease; however the underlying mechanisms remain elusive. Disturbance of the endothelial glycocalyx (EG), an important regulator of vessel function, is thought to contribute to vascular pathology. Here, we studied the EG with respect to gestational...

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Autores principales:	Alexandra Puchwein-Schwepcke, Stefanie Artmann, Lea Rajwich, Orsolya Genzel-Boroviczény, Claudia Nussbaum
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/aa38f59c8ec54480a7c98bfeac25b48f
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spelling	oai:doaj.org-article:aa38f59c8ec54480a7c98bfeac25b48f2021-12-02T10:44:21ZEffect of gestational age and postnatal age on the endothelial glycocalyx in neonates10.1038/s41598-021-81847-82045-2322https://doaj.org/article/aa38f59c8ec54480a7c98bfeac25b48f2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-81847-8https://doaj.org/toc/2045-2322Abstract Prematurity predisposes to cardiovascular disease; however the underlying mechanisms remain elusive. Disturbance of the endothelial glycocalyx (EG), an important regulator of vessel function, is thought to contribute to vascular pathology. Here, we studied the EG with respect to gestational and postnatal age in preterm and term neonates. The Perfused Boundary Region (PBR), an inverse measure of glycocalyx thickness, was measured postnatally in 85 term and 39 preterm neonates. Preterm neonates were further analyzed in two subgroups i.e., neonates born < 30 weeks gestational age (group A) and neonates born ≥ 30 weeks (group B). In preterm neonates, weekly follow-up measurements were performed if possible. PBR differed significantly between preterm and term neonates with lowest values representing largest EG dimension in extremely premature infants possibly reflecting its importance in fetal vascular development. Linear regression revealed a dependence of PBR on both, gestational age and postnatal age. Furthermore, hematocrit predicted longitudinal PBR changes. PBR measured in group A at a corrected age of > 30 weeks was significantly higher than in group B at birth, pointing towards an alteration of intrinsic maturational effects by extrinsic factors. These changes might contribute to the increased cardiovascular risk associated with extreme prematurity.Alexandra Puchwein-SchwepckeStefanie ArtmannLea RajwichOrsolya Genzel-BoroviczényClaudia NussbaumNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Alexandra Puchwein-Schwepcke Stefanie Artmann Lea Rajwich Orsolya Genzel-Boroviczény Claudia Nussbaum Effect of gestational age and postnatal age on the endothelial glycocalyx in neonates
description	Abstract Prematurity predisposes to cardiovascular disease; however the underlying mechanisms remain elusive. Disturbance of the endothelial glycocalyx (EG), an important regulator of vessel function, is thought to contribute to vascular pathology. Here, we studied the EG with respect to gestational and postnatal age in preterm and term neonates. The Perfused Boundary Region (PBR), an inverse measure of glycocalyx thickness, was measured postnatally in 85 term and 39 preterm neonates. Preterm neonates were further analyzed in two subgroups i.e., neonates born < 30 weeks gestational age (group A) and neonates born ≥ 30 weeks (group B). In preterm neonates, weekly follow-up measurements were performed if possible. PBR differed significantly between preterm and term neonates with lowest values representing largest EG dimension in extremely premature infants possibly reflecting its importance in fetal vascular development. Linear regression revealed a dependence of PBR on both, gestational age and postnatal age. Furthermore, hematocrit predicted longitudinal PBR changes. PBR measured in group A at a corrected age of > 30 weeks was significantly higher than in group B at birth, pointing towards an alteration of intrinsic maturational effects by extrinsic factors. These changes might contribute to the increased cardiovascular risk associated with extreme prematurity.
format	article
author	Alexandra Puchwein-Schwepcke Stefanie Artmann Lea Rajwich Orsolya Genzel-Boroviczény Claudia Nussbaum
author_facet	Alexandra Puchwein-Schwepcke Stefanie Artmann Lea Rajwich Orsolya Genzel-Boroviczény Claudia Nussbaum
author_sort	Alexandra Puchwein-Schwepcke
title	Effect of gestational age and postnatal age on the endothelial glycocalyx in neonates
title_short	Effect of gestational age and postnatal age on the endothelial glycocalyx in neonates
title_full	Effect of gestational age and postnatal age on the endothelial glycocalyx in neonates
title_fullStr	Effect of gestational age and postnatal age on the endothelial glycocalyx in neonates
title_full_unstemmed	Effect of gestational age and postnatal age on the endothelial glycocalyx in neonates
title_sort	effect of gestational age and postnatal age on the endothelial glycocalyx in neonates
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/aa38f59c8ec54480a7c98bfeac25b48f
work_keys_str_mv	AT alexandrapuchweinschwepcke effectofgestationalageandpostnatalageontheendothelialglycocalyxinneonates AT stefanieartmann effectofgestationalageandpostnatalageontheendothelialglycocalyxinneonates AT learajwich effectofgestationalageandpostnatalageontheendothelialglycocalyxinneonates AT orsolyagenzelboroviczeny effectofgestationalageandpostnatalageontheendothelialglycocalyxinneonates AT claudianussbaum effectofgestationalageandpostnatalageontheendothelialglycocalyxinneonates
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Effect of gestational age and postnatal age on the endothelial glycocalyx in neonates

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