Biomedical Applications of Multifunctional Polymeric Nanocarriers: A Review of Current Literature

Alicja Karabasz,1 Monika Bzowska,1 Krzysztof Szczepanowicz2 1Department of Cell Biochemistry, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Kraków, Poland; 2Jerzy Haber Institute of Catalysis and Surface Chemistry, Polish Academy of Sciences, Krak&oac...

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Autores principales:	Karabasz A, Bzowska M, Szczepanowicz K
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	polymeric nanocarriers biomedical application anti-cancer cancer immunotherapy modern vaccines regenerative medicine lifestyle diseases - diabetes Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/aa3a3d17cf35431d822d03c031e8f754
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spelling	oai:doaj.org-article:aa3a3d17cf35431d822d03c031e8f7542021-12-02T13:41:52ZBiomedical Applications of Multifunctional Polymeric Nanocarriers: A Review of Current Literature1178-2013https://doaj.org/article/aa3a3d17cf35431d822d03c031e8f7542020-11-01T00:00:00Zhttps://www.dovepress.com/biomedical-applications-of-multifunctional-polymeric-nanocarriers-a-re-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Alicja Karabasz,1 Monika Bzowska,1 Krzysztof Szczepanowicz2 1Department of Cell Biochemistry, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Kraków, Poland; 2Jerzy Haber Institute of Catalysis and Surface Chemistry, Polish Academy of Sciences, Kraków, PolandCorrespondence: Monika BzowskaDepartment of Cell Biochemistry, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, 7 Gronostajowa Street, Kraków 30-387, PolandTel/Fax +48 12 664 63 88Email monika.bzowska@uj.edu.plKrzysztof SzczepanowiczJerzy Haber Institute of Catalysis and Surface Chemistry, Polish Academy of Sciences, 8 Niezapominajek Street, Kraków 30-239, PolandTel/Fax +48 12 639 51 21Email ncszczep@cyf-kr.edu.plAbstract: Polymeric nanomaterials have become a prominent area of research in the field of drug delivery. Their application in nanomedicine can improve bioavailability, pharmacokinetics, and, therefore, the effectiveness of various therapeutics or contrast agents. There are many studies for developing new polymeric nanocarriers; however, their clinical application is somewhat limited. In this review, we present new complex and multifunctional polymeric nanocarriers as promising and innovative diagnostic or therapeutic systems. Their multifunctionality, resulting from the unique chemical and biological properties of the polymers used, ensures better delivery, and a controlled, sequential release of many different therapeutics to the diseased tissue. We present a brief introduction of the classical formulation techniques and describe examples of multifunctional nanocarriers, whose biological assessment has been carried out at least in vitro. Most of them, however, also underwent evaluation in vivo on animal models. Selected polymeric nanocarriers were grouped depending on their medical application: anti-cancer drug nanocarriers, nanomaterials delivering compounds for cancer immunotherapy or regenerative medicine, components of vaccines nanomaterials used for topical application, and lifestyle diseases, ie, diabetes.Keywords: polymeric nanocarriers, biomedical application, anti-cancer, cancer immunotherapy, modern vaccines, regenerative medicine, lifestyle diseases – diabetesKarabasz ABzowska MSzczepanowicz KDove Medical Pressarticlepolymeric nanocarriersbiomedical applicationanti-cancercancer immunotherapymodern vaccinesregenerative medicinelifestyle diseases - diabetesMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 15, Pp 8673-8696 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	polymeric nanocarriers biomedical application anti-cancer cancer immunotherapy modern vaccines regenerative medicine lifestyle diseases - diabetes Medicine (General) R5-920
spellingShingle	polymeric nanocarriers biomedical application anti-cancer cancer immunotherapy modern vaccines regenerative medicine lifestyle diseases - diabetes Medicine (General) R5-920 Karabasz A Bzowska M Szczepanowicz K Biomedical Applications of Multifunctional Polymeric Nanocarriers: A Review of Current Literature
description	Alicja Karabasz,1 Monika Bzowska,1 Krzysztof Szczepanowicz2 1Department of Cell Biochemistry, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Kraków, Poland; 2Jerzy Haber Institute of Catalysis and Surface Chemistry, Polish Academy of Sciences, Kraków, PolandCorrespondence: Monika BzowskaDepartment of Cell Biochemistry, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, 7 Gronostajowa Street, Kraków 30-387, PolandTel/Fax +48 12 664 63 88Email monika.bzowska@uj.edu.plKrzysztof SzczepanowiczJerzy Haber Institute of Catalysis and Surface Chemistry, Polish Academy of Sciences, 8 Niezapominajek Street, Kraków 30-239, PolandTel/Fax +48 12 639 51 21Email ncszczep@cyf-kr.edu.plAbstract: Polymeric nanomaterials have become a prominent area of research in the field of drug delivery. Their application in nanomedicine can improve bioavailability, pharmacokinetics, and, therefore, the effectiveness of various therapeutics or contrast agents. There are many studies for developing new polymeric nanocarriers; however, their clinical application is somewhat limited. In this review, we present new complex and multifunctional polymeric nanocarriers as promising and innovative diagnostic or therapeutic systems. Their multifunctionality, resulting from the unique chemical and biological properties of the polymers used, ensures better delivery, and a controlled, sequential release of many different therapeutics to the diseased tissue. We present a brief introduction of the classical formulation techniques and describe examples of multifunctional nanocarriers, whose biological assessment has been carried out at least in vitro. Most of them, however, also underwent evaluation in vivo on animal models. Selected polymeric nanocarriers were grouped depending on their medical application: anti-cancer drug nanocarriers, nanomaterials delivering compounds for cancer immunotherapy or regenerative medicine, components of vaccines nanomaterials used for topical application, and lifestyle diseases, ie, diabetes.Keywords: polymeric nanocarriers, biomedical application, anti-cancer, cancer immunotherapy, modern vaccines, regenerative medicine, lifestyle diseases – diabetes
format	article
author	Karabasz A Bzowska M Szczepanowicz K
author_facet	Karabasz A Bzowska M Szczepanowicz K
author_sort	Karabasz A
title	Biomedical Applications of Multifunctional Polymeric Nanocarriers: A Review of Current Literature
title_short	Biomedical Applications of Multifunctional Polymeric Nanocarriers: A Review of Current Literature
title_full	Biomedical Applications of Multifunctional Polymeric Nanocarriers: A Review of Current Literature
title_fullStr	Biomedical Applications of Multifunctional Polymeric Nanocarriers: A Review of Current Literature
title_full_unstemmed	Biomedical Applications of Multifunctional Polymeric Nanocarriers: A Review of Current Literature
title_sort	biomedical applications of multifunctional polymeric nanocarriers: a review of current literature
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/aa3a3d17cf35431d822d03c031e8f754
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Biomedical Applications of Multifunctional Polymeric Nanocarriers: A Review of Current Literature

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