In vivo toxicologic study of larger silica nanoparticles in mice

Wai-Tao Chan,1–3 Cheng-Che Liu,4 Jen-Shiu Chiang Chiau,5 Shang-Ting Tsai,6 Chih-Kai Liang,6 Mei-Lien Cheng,5 Hung-Chang Lee,7,8 Chun-Yun Yeung,1,3,9 Shao-Yi Hou2,6 1Department of Pediatric Gastroenterology, Hepatology and Nutrition, MacKay Children’s Hospital, 2Graduate Institut...

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Autores principales:	Chan WT, Liu CC, Chiang Chiau JS, Tsai ST, Liang CK, Cheng ML, Lee HC, Yeung CY, Hou SY
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	In vivo mice silica nanoparticle nanotoxicity Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/aa3a6a4924254594932d6f190216c788
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spelling	oai:doaj.org-article:aa3a6a4924254594932d6f190216c7882021-12-02T01:46:44ZIn vivo toxicologic study of larger silica nanoparticles in mice1178-2013https://doaj.org/article/aa3a6a4924254594932d6f190216c7882017-04-01T00:00:00Zhttps://www.dovepress.com/in-vivo-toxicologic-study-of-larger-silica-nanoparticles-in-mice-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Wai-Tao Chan,1–3 Cheng-Che Liu,4 Jen-Shiu Chiang Chiau,5 Shang-Ting Tsai,6 Chih-Kai Liang,6 Mei-Lien Cheng,5 Hung-Chang Lee,7,8 Chun-Yun Yeung,1,3,9 Shao-Yi Hou2,6 1Department of Pediatric Gastroenterology, Hepatology and Nutrition, MacKay Children’s Hospital, 2Graduate Institute of Engineering Technology, National Taipei University of Technology, 3Mackay Medicine, Nursing, and Management College, 4Institute of Preventive Medicine, National Defense Medical Center, Taipei, 5Department of Medical Research, MacKay Memorial Hospital, Hsinchu, 6Graduate Institute of Biochemical and Biomedical Engineering, National Taipei University of Technology, Taipei, 7Department of Pediatrics, MacKay Memorial Hospital, Hsinchu, 8Department of Pediatrics, Taipei Medical University, Taipei, 9Department of Medicine, Mackay Medical College, New Taipei, Taiwan, Republic of China Abstract: Silica nanoparticles (SiNPs) are being studied and used for medical purposes. As nanotechnology grows rapidly, its biosafety and toxicity have frequently raised concerns. However, diverse results have been reported about the safety of SiNPs; several studies reported that smaller particles might exhibit toxic effects to some cell lines, and larger particles of 100 nm were reported to be genotoxic to the cocultured cells. Here, we investigated the in vivo toxicity of SiNPs of 150 nm in various dosages via intravenous administration in mice. The mice were observed for 14 days before blood examination and histopathological assay. All the mice survived and behaved normally after the administration of nanoparticles. No significant weight change was noted. Blood examinations showed no definite systemic dysfunction of organ systems. Histopathological studies of vital organs confirmed no SiNP-related adverse effects. We concluded that 150 nm SiNPs were biocompatible and safe for in vivo use in mice. Keywords: in vivo, mice, silica nanoparticle, nanotoxicityChan WTLiu CCChiang Chiau JSTsai STLiang CKCheng MLLee HCYeung CYHou SYDove Medical PressarticleIn vivomicesilica nanoparticlenanotoxicityMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 12, Pp 3421-3432 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	In vivo mice silica nanoparticle nanotoxicity Medicine (General) R5-920
spellingShingle	In vivo mice silica nanoparticle nanotoxicity Medicine (General) R5-920 Chan WT Liu CC Chiang Chiau JS Tsai ST Liang CK Cheng ML Lee HC Yeung CY Hou SY In vivo toxicologic study of larger silica nanoparticles in mice
description	Wai-Tao Chan,1–3 Cheng-Che Liu,4 Jen-Shiu Chiang Chiau,5 Shang-Ting Tsai,6 Chih-Kai Liang,6 Mei-Lien Cheng,5 Hung-Chang Lee,7,8 Chun-Yun Yeung,1,3,9 Shao-Yi Hou2,6 1Department of Pediatric Gastroenterology, Hepatology and Nutrition, MacKay Children’s Hospital, 2Graduate Institute of Engineering Technology, National Taipei University of Technology, 3Mackay Medicine, Nursing, and Management College, 4Institute of Preventive Medicine, National Defense Medical Center, Taipei, 5Department of Medical Research, MacKay Memorial Hospital, Hsinchu, 6Graduate Institute of Biochemical and Biomedical Engineering, National Taipei University of Technology, Taipei, 7Department of Pediatrics, MacKay Memorial Hospital, Hsinchu, 8Department of Pediatrics, Taipei Medical University, Taipei, 9Department of Medicine, Mackay Medical College, New Taipei, Taiwan, Republic of China Abstract: Silica nanoparticles (SiNPs) are being studied and used for medical purposes. As nanotechnology grows rapidly, its biosafety and toxicity have frequently raised concerns. However, diverse results have been reported about the safety of SiNPs; several studies reported that smaller particles might exhibit toxic effects to some cell lines, and larger particles of 100 nm were reported to be genotoxic to the cocultured cells. Here, we investigated the in vivo toxicity of SiNPs of 150 nm in various dosages via intravenous administration in mice. The mice were observed for 14 days before blood examination and histopathological assay. All the mice survived and behaved normally after the administration of nanoparticles. No significant weight change was noted. Blood examinations showed no definite systemic dysfunction of organ systems. Histopathological studies of vital organs confirmed no SiNP-related adverse effects. We concluded that 150 nm SiNPs were biocompatible and safe for in vivo use in mice. Keywords: in vivo, mice, silica nanoparticle, nanotoxicity
format	article
author	Chan WT Liu CC Chiang Chiau JS Tsai ST Liang CK Cheng ML Lee HC Yeung CY Hou SY
author_facet	Chan WT Liu CC Chiang Chiau JS Tsai ST Liang CK Cheng ML Lee HC Yeung CY Hou SY
author_sort	Chan WT
title	In vivo toxicologic study of larger silica nanoparticles in mice
title_short	In vivo toxicologic study of larger silica nanoparticles in mice
title_full	In vivo toxicologic study of larger silica nanoparticles in mice
title_fullStr	In vivo toxicologic study of larger silica nanoparticles in mice
title_full_unstemmed	In vivo toxicologic study of larger silica nanoparticles in mice
title_sort	in vivo toxicologic study of larger silica nanoparticles in mice
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/aa3a6a4924254594932d6f190216c788
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In vivo toxicologic study of larger silica nanoparticles in mice

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