Single-molecule imaging correlates decreasing nuclear volume with increasing TF-chromatin associations during zebrafish development

Zygotic genome activation (ZGA), the onset of transcription after initial quiescence, is a major developmental step in many species. Here authors use single molecule tracking in live developing zebrafish embryos to show that increased transcription factor binding to DNA at ZGA is due to a shrinking...

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Auteurs principaux:	Matthias Reisser, Anja Palmer, Achim P. Popp, Christopher Jahn, Gilbert Weidinger, J. Christof M. Gebhardt
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2018
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/aa3a72768df54453a0f079cb56f836f5
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spelling	oai:doaj.org-article:aa3a72768df54453a0f079cb56f836f52021-12-02T17:32:32ZSingle-molecule imaging correlates decreasing nuclear volume with increasing TF-chromatin associations during zebrafish development10.1038/s41467-018-07731-82041-1723https://doaj.org/article/aa3a72768df54453a0f079cb56f836f52018-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07731-8https://doaj.org/toc/2041-1723Zygotic genome activation (ZGA), the onset of transcription after initial quiescence, is a major developmental step in many species. Here authors use single molecule tracking in live developing zebrafish embryos to show that increased transcription factor binding to DNA at ZGA is due to a shrinking nucleus.Matthias ReisserAnja PalmerAchim P. PoppChristopher JahnGilbert WeidingerJ. Christof M. GebhardtNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Matthias Reisser Anja Palmer Achim P. Popp Christopher Jahn Gilbert Weidinger J. Christof M. Gebhardt Single-molecule imaging correlates decreasing nuclear volume with increasing TF-chromatin associations during zebrafish development
description	Zygotic genome activation (ZGA), the onset of transcription after initial quiescence, is a major developmental step in many species. Here authors use single molecule tracking in live developing zebrafish embryos to show that increased transcription factor binding to DNA at ZGA is due to a shrinking nucleus.
format	article
author	Matthias Reisser Anja Palmer Achim P. Popp Christopher Jahn Gilbert Weidinger J. Christof M. Gebhardt
author_facet	Matthias Reisser Anja Palmer Achim P. Popp Christopher Jahn Gilbert Weidinger J. Christof M. Gebhardt
author_sort	Matthias Reisser
title	Single-molecule imaging correlates decreasing nuclear volume with increasing TF-chromatin associations during zebrafish development
title_short	Single-molecule imaging correlates decreasing nuclear volume with increasing TF-chromatin associations during zebrafish development
title_full	Single-molecule imaging correlates decreasing nuclear volume with increasing TF-chromatin associations during zebrafish development
title_fullStr	Single-molecule imaging correlates decreasing nuclear volume with increasing TF-chromatin associations during zebrafish development
title_full_unstemmed	Single-molecule imaging correlates decreasing nuclear volume with increasing TF-chromatin associations during zebrafish development
title_sort	single-molecule imaging correlates decreasing nuclear volume with increasing tf-chromatin associations during zebrafish development
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/aa3a72768df54453a0f079cb56f836f5
work_keys_str_mv	AT matthiasreisser singlemoleculeimagingcorrelatesdecreasingnuclearvolumewithincreasingtfchromatinassociationsduringzebrafishdevelopment AT anjapalmer singlemoleculeimagingcorrelatesdecreasingnuclearvolumewithincreasingtfchromatinassociationsduringzebrafishdevelopment AT achimppopp singlemoleculeimagingcorrelatesdecreasingnuclearvolumewithincreasingtfchromatinassociationsduringzebrafishdevelopment AT christopherjahn singlemoleculeimagingcorrelatesdecreasingnuclearvolumewithincreasingtfchromatinassociationsduringzebrafishdevelopment AT gilbertweidinger singlemoleculeimagingcorrelatesdecreasingnuclearvolumewithincreasingtfchromatinassociationsduringzebrafishdevelopment AT jchristofmgebhardt singlemoleculeimagingcorrelatesdecreasingnuclearvolumewithincreasingtfchromatinassociationsduringzebrafishdevelopment
_version_	1718380268412207104

Single-molecule imaging correlates decreasing nuclear volume with increasing TF-chromatin associations during zebrafish development

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