Locus coeruleus degeneration is associated with disorganized functional topology in Parkinson’s disease

Degeneration of the locus coeruleus (LC) is recognized as a critical hallmark of Parkinson's disease (PD). Recent studies have reported that noradrenaline produced from the LC has critical effects on brain functional organization. However, it is unknown if LC degeneration in PD contributes to c...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Cheng Zhou, Tao Guo, Xueqin Bai, JingJing Wu, Ting Gao, Xiaojun Guan, Xiaocao Liu, Luyan Gu, Peiyu Huang, Min Xuan, Quanquan Gu, Xiaojun Xu, Baorong Zhang, Minming Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Parkinson’s disease Locus coeruleus Magnetic resonance imaging Graph theory Functional networks Computer applications to medicine. Medical informatics R858-859.7 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/aa3a7370e25f4f4fa55abf41c166e85e
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:aa3a7370e25f4f4fa55abf41c166e85e
record_format	dspace
spelling	oai:doaj.org-article:aa3a7370e25f4f4fa55abf41c166e85e2021-11-06T04:28:11ZLocus coeruleus degeneration is associated with disorganized functional topology in Parkinson’s disease2213-158210.1016/j.nicl.2021.102873https://doaj.org/article/aa3a7370e25f4f4fa55abf41c166e85e2021-01-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S221315822100317Xhttps://doaj.org/toc/2213-1582Degeneration of the locus coeruleus (LC) is recognized as a critical hallmark of Parkinson's disease (PD). Recent studies have reported that noradrenaline produced from the LC has critical effects on brain functional organization. However, it is unknown if LC degeneration in PD contributes to cognitive/motor manifestations through modulating brain functional organization. This study enrolled 94 PD patients and 68 healthy controls, and LC integrity was measured using the contrast-to-noise ratio of the LC (CNRLC) calculated from T1-weighted magnetic resonance imaging. We used graph-theory-based network analysis to characterize brain functional organization. The relationships among LC degeneration, network disruption, and cognitive/motor manifestations in PD were assessed. Whether network disruption was a mediator between LC degeneration and cognitive/motor impairments was assessed further. In addition, an independent PD subgroup (n = 35) having functional magnetic resonance scanning before and after levodopa administration was enrolled to evaluate whether LC degeneration-related network deficiencies were independent of dopamine deficiency. We demonstrated that PD patients have significant LC degeneration compared to healthy controls. CNRLC was positively correlated with Montreal Cognitive Assessment score and the nodal efficiency (NE) of several cognitive-related regions. Lower NE of the superior temporal gyrus was a mediator between LC degeneration and cognitive impairment in PD. However, levodopa treatment could not normalize the reduced NE of the superior temporal gyrus (mediator). In conclusion, we provided evidence for the relationship between LC degeneration and extensive network disruption in PD, and highlight the role of network disorganization in LC degeneration-related cognitive impairment.Cheng ZhouTao GuoXueqin BaiJingJing WuTing GaoXiaojun GuanXiaocao LiuLuyan GuPeiyu HuangMin XuanQuanquan GuXiaojun XuBaorong ZhangMinming ZhangElsevierarticleParkinson’s diseaseLocus coeruleusMagnetic resonance imagingGraph theoryFunctional networksComputer applications to medicine. Medical informaticsR858-859.7Neurology. Diseases of the nervous systemRC346-429ENNeuroImage: Clinical, Vol 32, Iss , Pp 102873- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Parkinson’s disease Locus coeruleus Magnetic resonance imaging Graph theory Functional networks Computer applications to medicine. Medical informatics R858-859.7 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Parkinson’s disease Locus coeruleus Magnetic resonance imaging Graph theory Functional networks Computer applications to medicine. Medical informatics R858-859.7 Neurology. Diseases of the nervous system RC346-429 Cheng Zhou Tao Guo Xueqin Bai JingJing Wu Ting Gao Xiaojun Guan Xiaocao Liu Luyan Gu Peiyu Huang Min Xuan Quanquan Gu Xiaojun Xu Baorong Zhang Minming Zhang Locus coeruleus degeneration is associated with disorganized functional topology in Parkinson’s disease
description	Degeneration of the locus coeruleus (LC) is recognized as a critical hallmark of Parkinson's disease (PD). Recent studies have reported that noradrenaline produced from the LC has critical effects on brain functional organization. However, it is unknown if LC degeneration in PD contributes to cognitive/motor manifestations through modulating brain functional organization. This study enrolled 94 PD patients and 68 healthy controls, and LC integrity was measured using the contrast-to-noise ratio of the LC (CNRLC) calculated from T1-weighted magnetic resonance imaging. We used graph-theory-based network analysis to characterize brain functional organization. The relationships among LC degeneration, network disruption, and cognitive/motor manifestations in PD were assessed. Whether network disruption was a mediator between LC degeneration and cognitive/motor impairments was assessed further. In addition, an independent PD subgroup (n = 35) having functional magnetic resonance scanning before and after levodopa administration was enrolled to evaluate whether LC degeneration-related network deficiencies were independent of dopamine deficiency. We demonstrated that PD patients have significant LC degeneration compared to healthy controls. CNRLC was positively correlated with Montreal Cognitive Assessment score and the nodal efficiency (NE) of several cognitive-related regions. Lower NE of the superior temporal gyrus was a mediator between LC degeneration and cognitive impairment in PD. However, levodopa treatment could not normalize the reduced NE of the superior temporal gyrus (mediator). In conclusion, we provided evidence for the relationship between LC degeneration and extensive network disruption in PD, and highlight the role of network disorganization in LC degeneration-related cognitive impairment.
format	article
author	Cheng Zhou Tao Guo Xueqin Bai JingJing Wu Ting Gao Xiaojun Guan Xiaocao Liu Luyan Gu Peiyu Huang Min Xuan Quanquan Gu Xiaojun Xu Baorong Zhang Minming Zhang
author_facet	Cheng Zhou Tao Guo Xueqin Bai JingJing Wu Ting Gao Xiaojun Guan Xiaocao Liu Luyan Gu Peiyu Huang Min Xuan Quanquan Gu Xiaojun Xu Baorong Zhang Minming Zhang
author_sort	Cheng Zhou
title	Locus coeruleus degeneration is associated with disorganized functional topology in Parkinson’s disease
title_short	Locus coeruleus degeneration is associated with disorganized functional topology in Parkinson’s disease
title_full	Locus coeruleus degeneration is associated with disorganized functional topology in Parkinson’s disease
title_fullStr	Locus coeruleus degeneration is associated with disorganized functional topology in Parkinson’s disease
title_full_unstemmed	Locus coeruleus degeneration is associated with disorganized functional topology in Parkinson’s disease
title_sort	locus coeruleus degeneration is associated with disorganized functional topology in parkinson’s disease
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/aa3a7370e25f4f4fa55abf41c166e85e
work_keys_str_mv	AT chengzhou locuscoeruleusdegenerationisassociatedwithdisorganizedfunctionaltopologyinparkinsonsdisease AT taoguo locuscoeruleusdegenerationisassociatedwithdisorganizedfunctionaltopologyinparkinsonsdisease AT xueqinbai locuscoeruleusdegenerationisassociatedwithdisorganizedfunctionaltopologyinparkinsonsdisease AT jingjingwu locuscoeruleusdegenerationisassociatedwithdisorganizedfunctionaltopologyinparkinsonsdisease AT tinggao locuscoeruleusdegenerationisassociatedwithdisorganizedfunctionaltopologyinparkinsonsdisease AT xiaojunguan locuscoeruleusdegenerationisassociatedwithdisorganizedfunctionaltopologyinparkinsonsdisease AT xiaocaoliu locuscoeruleusdegenerationisassociatedwithdisorganizedfunctionaltopologyinparkinsonsdisease AT luyangu locuscoeruleusdegenerationisassociatedwithdisorganizedfunctionaltopologyinparkinsonsdisease AT peiyuhuang locuscoeruleusdegenerationisassociatedwithdisorganizedfunctionaltopologyinparkinsonsdisease AT minxuan locuscoeruleusdegenerationisassociatedwithdisorganizedfunctionaltopologyinparkinsonsdisease AT quanquangu locuscoeruleusdegenerationisassociatedwithdisorganizedfunctionaltopologyinparkinsonsdisease AT xiaojunxu locuscoeruleusdegenerationisassociatedwithdisorganizedfunctionaltopologyinparkinsonsdisease AT baorongzhang locuscoeruleusdegenerationisassociatedwithdisorganizedfunctionaltopologyinparkinsonsdisease AT minmingzhang locuscoeruleusdegenerationisassociatedwithdisorganizedfunctionaltopologyinparkinsonsdisease
_version_	1718443935619088384

Locus coeruleus degeneration is associated with disorganized functional topology in Parkinson’s disease

Ejemplares similares