A rare case of zolendronate infusion complication leading to glaucoma filtration surgery

A Khan1, G Lascaratos1, T Rane-Malcolm2, R Sanders21Princess Alexandra Eye Pavilion, Edinburgh, 2Department of Ophthalmology, Queen Margaret Hospital, Dunfermline, Fife, UKAbstract: Zolendronic acid is a nitrogenous biphosphonate commonly used as an intravenous infusion for the management of Paget&a...

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Autores principales:	Khan A, Lascaratos G, Rane-Malcolm T, Sanders R
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2011
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/aa3ea4303b414f11a096c0d2934f8d95
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spelling	oai:doaj.org-article:aa3ea4303b414f11a096c0d2934f8d952021-12-02T03:12:20ZA rare case of zolendronate infusion complication leading to glaucoma filtration surgery1177-54671177-5483https://doaj.org/article/aa3ea4303b414f11a096c0d2934f8d952011-08-01T00:00:00Zhttp://www.dovepress.com/a-rare-case-of-zolendronate-infusion-complication-leading-to-glaucoma--a8096https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483A Khan1, G Lascaratos1, T Rane-Malcolm2, R Sanders21Princess Alexandra Eye Pavilion, Edinburgh, 2Department of Ophthalmology, Queen Margaret Hospital, Dunfermline, Fife, UKAbstract: Zolendronic acid is a nitrogenous biphosphonate commonly used as an intravenous infusion for the management of Paget&rsquo;s disease, osteoporosis, and hypercalcemia of malignancy. We report a rare and challenging complication of zolendronate infusion: unilateral acute anterior uveitis followed by persistently raised intraocular pressure despite being on four different classes of antiglaucoma medication. The challenge was that the patient required topical steroid to treat her uveitis in the background of known glaucoma with corresponding steroid response. She eventually underwent a left phacotrabeculectomy augmented with 5-fluorouracil. Four weeks postoperatively she developed an encapsulated bleb and underwent needling with 5-fluorouracil. This case highlights the importance of having a high index of suspicion for anterior uveitis in patients with a red and painful eye after initiating biphosphonate therapy. Caution should also be exercised when prescribing biphosponates to glaucoma patients.Keywords: biphosponates, anterior uveitis, intraocular pressureKhan ALascaratos GRane-Malcolm TSanders RDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2011, Iss default, Pp 1147-1149 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Khan A Lascaratos G Rane-Malcolm T Sanders R A rare case of zolendronate infusion complication leading to glaucoma filtration surgery
description	A Khan1, G Lascaratos1, T Rane-Malcolm2, R Sanders21Princess Alexandra Eye Pavilion, Edinburgh, 2Department of Ophthalmology, Queen Margaret Hospital, Dunfermline, Fife, UKAbstract: Zolendronic acid is a nitrogenous biphosphonate commonly used as an intravenous infusion for the management of Paget&rsquo;s disease, osteoporosis, and hypercalcemia of malignancy. We report a rare and challenging complication of zolendronate infusion: unilateral acute anterior uveitis followed by persistently raised intraocular pressure despite being on four different classes of antiglaucoma medication. The challenge was that the patient required topical steroid to treat her uveitis in the background of known glaucoma with corresponding steroid response. She eventually underwent a left phacotrabeculectomy augmented with 5-fluorouracil. Four weeks postoperatively she developed an encapsulated bleb and underwent needling with 5-fluorouracil. This case highlights the importance of having a high index of suspicion for anterior uveitis in patients with a red and painful eye after initiating biphosphonate therapy. Caution should also be exercised when prescribing biphosponates to glaucoma patients.Keywords: biphosponates, anterior uveitis, intraocular pressure
format	article
author	Khan A Lascaratos G Rane-Malcolm T Sanders R
author_facet	Khan A Lascaratos G Rane-Malcolm T Sanders R
author_sort	Khan A
title	A rare case of zolendronate infusion complication leading to glaucoma filtration surgery
title_short	A rare case of zolendronate infusion complication leading to glaucoma filtration surgery
title_full	A rare case of zolendronate infusion complication leading to glaucoma filtration surgery
title_fullStr	A rare case of zolendronate infusion complication leading to glaucoma filtration surgery
title_full_unstemmed	A rare case of zolendronate infusion complication leading to glaucoma filtration surgery
title_sort	rare case of zolendronate infusion complication leading to glaucoma filtration surgery
publisher	Dove Medical Press
publishDate	2011
url	https://doaj.org/article/aa3ea4303b414f11a096c0d2934f8d95
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A rare case of zolendronate infusion complication leading to glaucoma filtration surgery

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