Role of Borneol Induced Autophagy in Enhancing Radiosensitivity of Malignant Glioma

Glioma is the common primary craniocerebral malignancy with unfavorable prognosis. It is currently treated by surgical resection supplemented by radiotherapy, although the resistance of glioma cells to radiation limits the therapeutic outcomes. The aim of the present study was to determine the poten...

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Autores principales:	Qinglin Li, Liang Xia, Caixing Sun, Huangjie Zhang, Mengying Zheng, Hongyan Zhang, Hongyang Lu, Zeng Wang
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	natural product borneol malignant glioma autophagy HIF-1α Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/aa40e67f51824214aa77a62edfed7f6b
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spelling	oai:doaj.org-article:aa40e67f51824214aa77a62edfed7f6b2021-12-01T15:00:13ZRole of Borneol Induced Autophagy in Enhancing Radiosensitivity of Malignant Glioma2234-943X10.3389/fonc.2021.749987https://doaj.org/article/aa40e67f51824214aa77a62edfed7f6b2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fonc.2021.749987/fullhttps://doaj.org/toc/2234-943XGlioma is the common primary craniocerebral malignancy with unfavorable prognosis. It is currently treated by surgical resection supplemented by radiotherapy, although the resistance of glioma cells to radiation limits the therapeutic outcomes. The aim of the present study was to determine the potential radiosensitizing effects of borneol and the underlying mechanisms. We found that borneol administration along with radiotherapy significantly inhibited the growth of primary glioma cells in vitro and in vivo. Furthermore, borneol markedly increased the number of autophagosomes in the glioma cells, which coincided with increased expression of beclin-1 and LC3. And the combination of borneol and radiation exposure significantly decreased the expression levels of HIF-1α, mTORC1 and eIF4E. In addition, silencing mTORC1 and eIF4E upregulated Beclin-1 and LC3 and decreased the expression of HIF-1α, thereby inhibiting tumor cell proliferation. Our findings suggest that borneol sensitizes glioma cells to radiation by inducing autophagy via inhibition of the mTORC1/eIF4E/HIF-1α regulatory axis.Qinglin LiLiang XiaCaixing SunHuangjie ZhangMengying ZhengHongyan ZhangHongyang LuZeng WangFrontiers Media S.A.articlenatural productborneolmalignant gliomaautophagyHIF-1αNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENFrontiers in Oncology, Vol 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	natural product borneol malignant glioma autophagy HIF-1α Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	natural product borneol malignant glioma autophagy HIF-1α Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Qinglin Li Liang Xia Caixing Sun Huangjie Zhang Mengying Zheng Hongyan Zhang Hongyang Lu Zeng Wang Role of Borneol Induced Autophagy in Enhancing Radiosensitivity of Malignant Glioma
description	Glioma is the common primary craniocerebral malignancy with unfavorable prognosis. It is currently treated by surgical resection supplemented by radiotherapy, although the resistance of glioma cells to radiation limits the therapeutic outcomes. The aim of the present study was to determine the potential radiosensitizing effects of borneol and the underlying mechanisms. We found that borneol administration along with radiotherapy significantly inhibited the growth of primary glioma cells in vitro and in vivo. Furthermore, borneol markedly increased the number of autophagosomes in the glioma cells, which coincided with increased expression of beclin-1 and LC3. And the combination of borneol and radiation exposure significantly decreased the expression levels of HIF-1α, mTORC1 and eIF4E. In addition, silencing mTORC1 and eIF4E upregulated Beclin-1 and LC3 and decreased the expression of HIF-1α, thereby inhibiting tumor cell proliferation. Our findings suggest that borneol sensitizes glioma cells to radiation by inducing autophagy via inhibition of the mTORC1/eIF4E/HIF-1α regulatory axis.
format	article
author	Qinglin Li Liang Xia Caixing Sun Huangjie Zhang Mengying Zheng Hongyan Zhang Hongyang Lu Zeng Wang
author_facet	Qinglin Li Liang Xia Caixing Sun Huangjie Zhang Mengying Zheng Hongyan Zhang Hongyang Lu Zeng Wang
author_sort	Qinglin Li
title	Role of Borneol Induced Autophagy in Enhancing Radiosensitivity of Malignant Glioma
title_short	Role of Borneol Induced Autophagy in Enhancing Radiosensitivity of Malignant Glioma
title_full	Role of Borneol Induced Autophagy in Enhancing Radiosensitivity of Malignant Glioma
title_fullStr	Role of Borneol Induced Autophagy in Enhancing Radiosensitivity of Malignant Glioma
title_full_unstemmed	Role of Borneol Induced Autophagy in Enhancing Radiosensitivity of Malignant Glioma
title_sort	role of borneol induced autophagy in enhancing radiosensitivity of malignant glioma
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/aa40e67f51824214aa77a62edfed7f6b
work_keys_str_mv	AT qinglinli roleofborneolinducedautophagyinenhancingradiosensitivityofmalignantglioma AT liangxia roleofborneolinducedautophagyinenhancingradiosensitivityofmalignantglioma AT caixingsun roleofborneolinducedautophagyinenhancingradiosensitivityofmalignantglioma AT huangjiezhang roleofborneolinducedautophagyinenhancingradiosensitivityofmalignantglioma AT mengyingzheng roleofborneolinducedautophagyinenhancingradiosensitivityofmalignantglioma AT hongyanzhang roleofborneolinducedautophagyinenhancingradiosensitivityofmalignantglioma AT hongyanglu roleofborneolinducedautophagyinenhancingradiosensitivityofmalignantglioma AT zengwang roleofborneolinducedautophagyinenhancingradiosensitivityofmalignantglioma
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Role of Borneol Induced Autophagy in Enhancing Radiosensitivity of Malignant Glioma

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