Adjunctive therapy in Parkinson's disease: the role of rasagiline
Kathryn D Gaines,1 Vanessa K Hinson21Department of Neurology, Aurora Advanced Healthcare, Milwaukee, WI, 2Department of Neurosciences, Movement Disorders Program, Medical University of South Carolina, Charleston, SC, USAAbstract: Parkinson's disease is the second most common neurodegener...
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Dove Medical Press
2012
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oai:doaj.org-article:aa42f0d91b954ce2a8df80a3d2961a922021-12-02T06:45:25ZAdjunctive therapy in Parkinson's disease: the role of rasagiline1176-63281178-2021https://doaj.org/article/aa42f0d91b954ce2a8df80a3d2961a922012-07-01T00:00:00Zhttp://www.dovepress.com/adjunctive-therapy-in-parkinson39s-disease-the-role-of-rasagiline-a10270https://doaj.org/toc/1176-6328https://doaj.org/toc/1178-2021Kathryn D Gaines,1 Vanessa K Hinson21Department of Neurology, Aurora Advanced Healthcare, Milwaukee, WI, 2Department of Neurosciences, Movement Disorders Program, Medical University of South Carolina, Charleston, SC, USAAbstract: Parkinson's disease is the second most common neurodegenerative disorder, currently affecting 1.5 million people in the US. In this review, we describe the diagnostic and pathological features of Parkinson's disease, as well as its clinical course. We then review pharmacologic treatments for the disease, with a particular focus on therapies adjunctive to levodopa and specifically the role of rasagiline. We review the four pivotal rasagiline trials, and discuss rasagiline and its use as adjunctive therapy for Parkinson's disease. Finally, we discuss potential side effects, drug interactions, and other practical aspects concerning the use of rasagiline in Parkinson's disease.Keywords: Parkinson's disease, treatment, rasagiline, clinical trialsGaines KDHinson VKDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2012, Iss default, Pp 285-294 (2012) |
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DOAJ |
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EN |
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Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 |
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Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Gaines KD Hinson VK Adjunctive therapy in Parkinson's disease: the role of rasagiline |
| description |
Kathryn D Gaines,1 Vanessa K Hinson21Department of Neurology, Aurora Advanced Healthcare, Milwaukee, WI, 2Department of Neurosciences, Movement Disorders Program, Medical University of South Carolina, Charleston, SC, USAAbstract: Parkinson's disease is the second most common neurodegenerative disorder, currently affecting 1.5 million people in the US. In this review, we describe the diagnostic and pathological features of Parkinson's disease, as well as its clinical course. We then review pharmacologic treatments for the disease, with a particular focus on therapies adjunctive to levodopa and specifically the role of rasagiline. We review the four pivotal rasagiline trials, and discuss rasagiline and its use as adjunctive therapy for Parkinson's disease. Finally, we discuss potential side effects, drug interactions, and other practical aspects concerning the use of rasagiline in Parkinson's disease.Keywords: Parkinson's disease, treatment, rasagiline, clinical trials |
| format |
article |
| author |
Gaines KD Hinson VK |
| author_facet |
Gaines KD Hinson VK |
| author_sort |
Gaines KD |
| title |
Adjunctive therapy in Parkinson's disease: the role of rasagiline |
| title_short |
Adjunctive therapy in Parkinson's disease: the role of rasagiline |
| title_full |
Adjunctive therapy in Parkinson's disease: the role of rasagiline |
| title_fullStr |
Adjunctive therapy in Parkinson's disease: the role of rasagiline |
| title_full_unstemmed |
Adjunctive therapy in Parkinson's disease: the role of rasagiline |
| title_sort |
adjunctive therapy in parkinson's disease: the role of rasagiline |
| publisher |
Dove Medical Press |
| publishDate |
2012 |
| url |
https://doaj.org/article/aa42f0d91b954ce2a8df80a3d2961a92 |
| work_keys_str_mv |
AT gaineskd adjunctivetherapyinparkinsonamp39sdiseasetheroleofrasagiline AT hinsonvk adjunctivetherapyinparkinsonamp39sdiseasetheroleofrasagiline |
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