Dual vaccination against IL-4 and IL-13 protects against chronic allergic asthma in mice

Asthma is caused by hyperreactivity to benign antigens, with humoral immunity orchestrated by interleukin-4 (IL-4) and IL-13 being the key etiological factor. Here the authors show, in humanized mouse models, that dual vaccination against IL-4 and IL-13 induces their durable suppression ameliorate e...

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Autores principales:	Eva Conde, Romain Bertrand, Bianca Balbino, Jonathan Bonnefoy, Julien Stackowicz, Noémie Caillot, Fabien Colaone, Samir Hamdi, Raïssa Houmadi, Alexia Loste, Jasper B. J. Kamphuis, François Huetz, Laurent Guilleminault, Nicolas Gaudenzio, Aurélie Mougel, David Hardy, John N. Snouwaert, Beverly H. Koller, Vincent Serra, Pierre Bruhns, Géraldine Grouard-Vogel, Laurent L. Reber
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/aa43d94c3b9c4cd69ba35a1d0034149e
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spelling	oai:doaj.org-article:aa43d94c3b9c4cd69ba35a1d0034149e2021-12-02T16:57:13ZDual vaccination against IL-4 and IL-13 protects against chronic allergic asthma in mice10.1038/s41467-021-22834-52041-1723https://doaj.org/article/aa43d94c3b9c4cd69ba35a1d0034149e2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22834-5https://doaj.org/toc/2041-1723Asthma is caused by hyperreactivity to benign antigens, with humoral immunity orchestrated by interleukin-4 (IL-4) and IL-13 being the key etiological factor. Here the authors show, in humanized mouse models, that dual vaccination against IL-4 and IL-13 induces their durable suppression ameliorate experimental asthma, and to hint clinical translation.Eva CondeRomain BertrandBianca BalbinoJonathan BonnefoyJulien StackowiczNoémie CaillotFabien ColaoneSamir HamdiRaïssa HoumadiAlexia LosteJasper B. J. KamphuisFrançois HuetzLaurent GuilleminaultNicolas GaudenzioAurélie MougelDavid HardyJohn N. SnouwaertBeverly H. KollerVincent SerraPierre BruhnsGéraldine Grouard-VogelLaurent L. ReberNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Eva Conde Romain Bertrand Bianca Balbino Jonathan Bonnefoy Julien Stackowicz Noémie Caillot Fabien Colaone Samir Hamdi Raïssa Houmadi Alexia Loste Jasper B. J. Kamphuis François Huetz Laurent Guilleminault Nicolas Gaudenzio Aurélie Mougel David Hardy John N. Snouwaert Beverly H. Koller Vincent Serra Pierre Bruhns Géraldine Grouard-Vogel Laurent L. Reber Dual vaccination against IL-4 and IL-13 protects against chronic allergic asthma in mice
description	Asthma is caused by hyperreactivity to benign antigens, with humoral immunity orchestrated by interleukin-4 (IL-4) and IL-13 being the key etiological factor. Here the authors show, in humanized mouse models, that dual vaccination against IL-4 and IL-13 induces their durable suppression ameliorate experimental asthma, and to hint clinical translation.
format	article
author	Eva Conde Romain Bertrand Bianca Balbino Jonathan Bonnefoy Julien Stackowicz Noémie Caillot Fabien Colaone Samir Hamdi Raïssa Houmadi Alexia Loste Jasper B. J. Kamphuis François Huetz Laurent Guilleminault Nicolas Gaudenzio Aurélie Mougel David Hardy John N. Snouwaert Beverly H. Koller Vincent Serra Pierre Bruhns Géraldine Grouard-Vogel Laurent L. Reber
author_facet	Eva Conde Romain Bertrand Bianca Balbino Jonathan Bonnefoy Julien Stackowicz Noémie Caillot Fabien Colaone Samir Hamdi Raïssa Houmadi Alexia Loste Jasper B. J. Kamphuis François Huetz Laurent Guilleminault Nicolas Gaudenzio Aurélie Mougel David Hardy John N. Snouwaert Beverly H. Koller Vincent Serra Pierre Bruhns Géraldine Grouard-Vogel Laurent L. Reber
author_sort	Eva Conde
title	Dual vaccination against IL-4 and IL-13 protects against chronic allergic asthma in mice
title_short	Dual vaccination against IL-4 and IL-13 protects against chronic allergic asthma in mice
title_full	Dual vaccination against IL-4 and IL-13 protects against chronic allergic asthma in mice
title_fullStr	Dual vaccination against IL-4 and IL-13 protects against chronic allergic asthma in mice
title_full_unstemmed	Dual vaccination against IL-4 and IL-13 protects against chronic allergic asthma in mice
title_sort	dual vaccination against il-4 and il-13 protects against chronic allergic asthma in mice
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/aa43d94c3b9c4cd69ba35a1d0034149e
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Dual vaccination against IL-4 and IL-13 protects against chronic allergic asthma in mice

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