Adropin and spexin hormones regulate the systemic inflammation in adenine-induced chronic kidney failure in rat

Chronic kidney disease is one of the major global health problems. Chronic renal failure is stimulated by many cytokines and chemokines. Adropin and spexin (SPX) are peptides hormones. These peptides could affect inflammatory conditions, but this is unclear. Due to the limited information, we planne...

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Autores principales:	Gulsun Memi, Burak Yazgan
Formato:	article
Lenguaje:	EN
Publicado:	Wolters Kluwer Medknow Publications 2021
Materias:	adropin chronic kidney failure inflammation interleukin spexin Physiology QP1-981
Acceso en línea:	https://doaj.org/article/aa476d12accd4d32bc94cd4939b2148d
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spelling	oai:doaj.org-article:aa476d12accd4d32bc94cd4939b2148d2021-11-12T10:09:38ZAdropin and spexin hormones regulate the systemic inflammation in adenine-induced chronic kidney failure in rat0304-49202666-005910.4103/cjp.cjp_13_21https://doaj.org/article/aa476d12accd4d32bc94cd4939b2148d2021-01-01T00:00:00Zhttp://www.cjphysiology.org/article.asp?issn=0304-4920;year=2021;volume=64;issue=4;spage=194;epage=201;aulast=Memihttps://doaj.org/toc/0304-4920https://doaj.org/toc/2666-0059Chronic kidney disease is one of the major global health problems. Chronic renal failure is stimulated by many cytokines and chemokines. Adropin and spexin (SPX) are peptides hormones. These peptides could affect inflammatory conditions, but this is unclear. Due to the limited information, we planned to investigate the impact of adropin and SPX hormones on systemic inflammation in adenine induced chronic kidney failure rat model. Chronic kidney failure was induced by administering adenine hemisulfate. Renal functions were measured by an autoanalyzer. Granulocyte colony-stimulating factor (G-CSF), interferon-gamma (IFN-γ), interleukin (IL)-1β, IL-2, IL-4, IL-5, IL-10, IL-12, IL-13, IL-17A, tumor necrosis factor-alpha, Eotaxin, growth-regulated oncogene-alpha, IP-10, monocyte chemoattractant protein (MCP)-1, MCP-3, macrophage inflammatory protein (MIP)-1α, MIP-2, and RANTES levels were determined by Luminex. We observed an increase in 24-h urine volume and serum creatinine. Blood urea nitrogen (BUN) and urine protein levels were also significantly higher in the chronic kidney failure (CKF) group. Urine protein and 24-h urine volume were reduced with adropin and SPX treatments. Furthermore, G-CSF, IFN-γ, IL-4, IL-5, IL-10, IL-12, IL-17A, and GRO-α significantly increased by CKF induction; however, these cytokines and chemokines significantly decreased by adropin treatment in the CKF group. Furthermore, adropin increased IP-10, MCP-1, MIP-1α, and MIP-2 levels. In addition, SPX treatment had a more limited effect, decreasing only G-CSF, IFN-γ, and IL-5 levels. The combined adropin + SPX treatment significantly reduced G-CSF, IFN-γ, IL-4, IL-5, IL-12, and IL-17A. Furthermore, IP-10, MCP-1, MCP-3, and MIP-2 were significantly increased by these combined treatments. Our findings indicate that renal functions and inflammatory response were modulated by adropin and SPX peptides. These peptides may have protective effects on systemic inflammation and renal failure progression.Gulsun MemiBurak YazganWolters Kluwer Medknow Publicationsarticleadropinchronic kidney failureinflammationinterleukinspexinPhysiologyQP1-981ENChinese Journal of Physiology, Vol 64, Iss 4, Pp 194-201 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	adropin chronic kidney failure inflammation interleukin spexin Physiology QP1-981
spellingShingle	adropin chronic kidney failure inflammation interleukin spexin Physiology QP1-981 Gulsun Memi Burak Yazgan Adropin and spexin hormones regulate the systemic inflammation in adenine-induced chronic kidney failure in rat
description	Chronic kidney disease is one of the major global health problems. Chronic renal failure is stimulated by many cytokines and chemokines. Adropin and spexin (SPX) are peptides hormones. These peptides could affect inflammatory conditions, but this is unclear. Due to the limited information, we planned to investigate the impact of adropin and SPX hormones on systemic inflammation in adenine induced chronic kidney failure rat model. Chronic kidney failure was induced by administering adenine hemisulfate. Renal functions were measured by an autoanalyzer. Granulocyte colony-stimulating factor (G-CSF), interferon-gamma (IFN-γ), interleukin (IL)-1β, IL-2, IL-4, IL-5, IL-10, IL-12, IL-13, IL-17A, tumor necrosis factor-alpha, Eotaxin, growth-regulated oncogene-alpha, IP-10, monocyte chemoattractant protein (MCP)-1, MCP-3, macrophage inflammatory protein (MIP)-1α, MIP-2, and RANTES levels were determined by Luminex. We observed an increase in 24-h urine volume and serum creatinine. Blood urea nitrogen (BUN) and urine protein levels were also significantly higher in the chronic kidney failure (CKF) group. Urine protein and 24-h urine volume were reduced with adropin and SPX treatments. Furthermore, G-CSF, IFN-γ, IL-4, IL-5, IL-10, IL-12, IL-17A, and GRO-α significantly increased by CKF induction; however, these cytokines and chemokines significantly decreased by adropin treatment in the CKF group. Furthermore, adropin increased IP-10, MCP-1, MIP-1α, and MIP-2 levels. In addition, SPX treatment had a more limited effect, decreasing only G-CSF, IFN-γ, and IL-5 levels. The combined adropin + SPX treatment significantly reduced G-CSF, IFN-γ, IL-4, IL-5, IL-12, and IL-17A. Furthermore, IP-10, MCP-1, MCP-3, and MIP-2 were significantly increased by these combined treatments. Our findings indicate that renal functions and inflammatory response were modulated by adropin and SPX peptides. These peptides may have protective effects on systemic inflammation and renal failure progression.
format	article
author	Gulsun Memi Burak Yazgan
author_facet	Gulsun Memi Burak Yazgan
author_sort	Gulsun Memi
title	Adropin and spexin hormones regulate the systemic inflammation in adenine-induced chronic kidney failure in rat
title_short	Adropin and spexin hormones regulate the systemic inflammation in adenine-induced chronic kidney failure in rat
title_full	Adropin and spexin hormones regulate the systemic inflammation in adenine-induced chronic kidney failure in rat
title_fullStr	Adropin and spexin hormones regulate the systemic inflammation in adenine-induced chronic kidney failure in rat
title_full_unstemmed	Adropin and spexin hormones regulate the systemic inflammation in adenine-induced chronic kidney failure in rat
title_sort	adropin and spexin hormones regulate the systemic inflammation in adenine-induced chronic kidney failure in rat
publisher	Wolters Kluwer Medknow Publications
publishDate	2021
url	https://doaj.org/article/aa476d12accd4d32bc94cd4939b2148d
work_keys_str_mv	AT gulsunmemi adropinandspexinhormonesregulatethesystemicinflammationinadenineinducedchronickidneyfailureinrat AT burakyazgan adropinandspexinhormonesregulatethesystemicinflammationinadenineinducedchronickidneyfailureinrat
_version_	1718431071040700416

Adropin and spexin hormones regulate the systemic inflammation in adenine-induced chronic kidney failure in rat

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