Robustness of sex-differences in functional connectivity over time in middle-aged marmosets

Abstract Nonhuman primates (NHPs) are an essential research model for gaining a comprehensive understanding of the neural mechanisms of neurocognitive aging in our own species. In the present study, we used resting state functional connectivity (rsFC) to investigate the relationship between prefront...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Benjamin C. Nephew, Marcelo Febo, Ryan Cali, Kathryn P. Workman, Laurellee Payne, Constance M. Moore, Jean A. King, Agnès Lacreuse
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/aa4a71dbbf2c4b7f9115486bfba354e8
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:aa4a71dbbf2c4b7f9115486bfba354e8
record_format	dspace
spelling	oai:doaj.org-article:aa4a71dbbf2c4b7f9115486bfba354e82021-12-02T18:37:07ZRobustness of sex-differences in functional connectivity over time in middle-aged marmosets10.1038/s41598-020-73811-92045-2322https://doaj.org/article/aa4a71dbbf2c4b7f9115486bfba354e82020-10-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-73811-9https://doaj.org/toc/2045-2322Abstract Nonhuman primates (NHPs) are an essential research model for gaining a comprehensive understanding of the neural mechanisms of neurocognitive aging in our own species. In the present study, we used resting state functional connectivity (rsFC) to investigate the relationship between prefrontal cortical and striatal neural interactions, and cognitive flexibility, in unanaesthetized common marmosets (Callithrix jacchus) at two time points during late middle age (8 months apart, similar to a span of 5–6 years in humans). Based on our previous findings, we also determine the reproducibility of connectivity measures over the course of 8 months, particularly previously observed sex differences in rsFC. Male marmosets exhibited remarkably similar patterns of stronger functional connectivity relative to females and greater cognitive flexibility between the two imaging time points. Network analysis revealed that the consistent sex differences in connectivity and related cognitive associations were characterized by greater node strength and/or degree values in several prefrontal, premotor and temporal regions, as well as stronger intra PFC connectivity, in males compared to females. The current study supports the existence of robust sex differences in prefrontal and striatal resting state networks that may contribute to differences in cognitive function and offers insight on the neural systems that may be compromised in cognitive aging and age-related conditions such as mild cognitive impairment and Alzheimer’s disease.Benjamin C. NephewMarcelo FeboRyan CaliKathryn P. WorkmanLaurellee PayneConstance M. MooreJean A. KingAgnès LacreuseNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Benjamin C. Nephew Marcelo Febo Ryan Cali Kathryn P. Workman Laurellee Payne Constance M. Moore Jean A. King Agnès Lacreuse Robustness of sex-differences in functional connectivity over time in middle-aged marmosets
description	Abstract Nonhuman primates (NHPs) are an essential research model for gaining a comprehensive understanding of the neural mechanisms of neurocognitive aging in our own species. In the present study, we used resting state functional connectivity (rsFC) to investigate the relationship between prefrontal cortical and striatal neural interactions, and cognitive flexibility, in unanaesthetized common marmosets (Callithrix jacchus) at two time points during late middle age (8 months apart, similar to a span of 5–6 years in humans). Based on our previous findings, we also determine the reproducibility of connectivity measures over the course of 8 months, particularly previously observed sex differences in rsFC. Male marmosets exhibited remarkably similar patterns of stronger functional connectivity relative to females and greater cognitive flexibility between the two imaging time points. Network analysis revealed that the consistent sex differences in connectivity and related cognitive associations were characterized by greater node strength and/or degree values in several prefrontal, premotor and temporal regions, as well as stronger intra PFC connectivity, in males compared to females. The current study supports the existence of robust sex differences in prefrontal and striatal resting state networks that may contribute to differences in cognitive function and offers insight on the neural systems that may be compromised in cognitive aging and age-related conditions such as mild cognitive impairment and Alzheimer’s disease.
format	article
author	Benjamin C. Nephew Marcelo Febo Ryan Cali Kathryn P. Workman Laurellee Payne Constance M. Moore Jean A. King Agnès Lacreuse
author_facet	Benjamin C. Nephew Marcelo Febo Ryan Cali Kathryn P. Workman Laurellee Payne Constance M. Moore Jean A. King Agnès Lacreuse
author_sort	Benjamin C. Nephew
title	Robustness of sex-differences in functional connectivity over time in middle-aged marmosets
title_short	Robustness of sex-differences in functional connectivity over time in middle-aged marmosets
title_full	Robustness of sex-differences in functional connectivity over time in middle-aged marmosets
title_fullStr	Robustness of sex-differences in functional connectivity over time in middle-aged marmosets
title_full_unstemmed	Robustness of sex-differences in functional connectivity over time in middle-aged marmosets
title_sort	robustness of sex-differences in functional connectivity over time in middle-aged marmosets
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/aa4a71dbbf2c4b7f9115486bfba354e8
work_keys_str_mv	AT benjamincnephew robustnessofsexdifferencesinfunctionalconnectivityovertimeinmiddleagedmarmosets AT marcelofebo robustnessofsexdifferencesinfunctionalconnectivityovertimeinmiddleagedmarmosets AT ryancali robustnessofsexdifferencesinfunctionalconnectivityovertimeinmiddleagedmarmosets AT kathrynpworkman robustnessofsexdifferencesinfunctionalconnectivityovertimeinmiddleagedmarmosets AT laurelleepayne robustnessofsexdifferencesinfunctionalconnectivityovertimeinmiddleagedmarmosets AT constancemmoore robustnessofsexdifferencesinfunctionalconnectivityovertimeinmiddleagedmarmosets AT jeanaking robustnessofsexdifferencesinfunctionalconnectivityovertimeinmiddleagedmarmosets AT agneslacreuse robustnessofsexdifferencesinfunctionalconnectivityovertimeinmiddleagedmarmosets
_version_	1718377819282604032

Robustness of sex-differences in functional connectivity over time in middle-aged marmosets

Ejemplares similares