Bioengineered 3D models of human pancreatic cancer recapitulate in vivo tumour biology

Bioengineered 3D models of human pancreatic cancer recapitulate in vivo tumour biology

Personalized cancer medicine currently lacks custom platforms that mimic the microenvironment of human tissues. Here, the authors show how self-assembled patient-derived models of pancreatic cancer recapitulate key biological features of the original tumours such as matrix composition and stemness.

Guardado en:
Detalles Bibliográficos
Autores principales: David Osuna de la Peña, Sara Maria David Trabulo, Estelle Collin, Ying Liu, Shreya Sharma, Marianthi Tatari, Diana Behrens, Mert Erkan, Rita T. Lawlor, Aldo Scarpa, Christopher Heeschen, Alvaro Mata, Daniela Loessner
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/aa4d680a8e804181b1c4842a522ec5d8
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:aa4d680a8e804181b1c4842a522ec5d8
record_format dspace
spelling oai:doaj.org-article:aa4d680a8e804181b1c4842a522ec5d82021-12-02T18:48:11ZBioengineered 3D models of human pancreatic cancer recapitulate in vivo tumour biology10.1038/s41467-021-25921-92041-1723https://doaj.org/article/aa4d680a8e804181b1c4842a522ec5d82021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25921-9https://doaj.org/toc/2041-1723Personalized cancer medicine currently lacks custom platforms that mimic the microenvironment of human tissues. Here, the authors show how self-assembled patient-derived models of pancreatic cancer recapitulate key biological features of the original tumours such as matrix composition and stemness.David Osuna de la PeñaSara Maria David TrabuloEstelle CollinYing LiuShreya SharmaMarianthi TatariDiana BehrensMert ErkanRita T. LawlorAldo ScarpaChristopher HeeschenAlvaro MataDaniela LoessnerNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
David Osuna de la Peña
Sara Maria David Trabulo
Estelle Collin
Ying Liu
Shreya Sharma
Marianthi Tatari
Diana Behrens
Mert Erkan
Rita T. Lawlor
Aldo Scarpa
Christopher Heeschen
Alvaro Mata
Daniela Loessner
Bioengineered 3D models of human pancreatic cancer recapitulate in vivo tumour biology
description Personalized cancer medicine currently lacks custom platforms that mimic the microenvironment of human tissues. Here, the authors show how self-assembled patient-derived models of pancreatic cancer recapitulate key biological features of the original tumours such as matrix composition and stemness.
format article
author David Osuna de la Peña
Sara Maria David Trabulo
Estelle Collin
Ying Liu
Shreya Sharma
Marianthi Tatari
Diana Behrens
Mert Erkan
Rita T. Lawlor
Aldo Scarpa
Christopher Heeschen
Alvaro Mata
Daniela Loessner
author_facet David Osuna de la Peña
Sara Maria David Trabulo
Estelle Collin
Ying Liu
Shreya Sharma
Marianthi Tatari
Diana Behrens
Mert Erkan
Rita T. Lawlor
Aldo Scarpa
Christopher Heeschen
Alvaro Mata
Daniela Loessner
author_sort David Osuna de la Peña
title Bioengineered 3D models of human pancreatic cancer recapitulate in vivo tumour biology
title_short Bioengineered 3D models of human pancreatic cancer recapitulate in vivo tumour biology
title_full Bioengineered 3D models of human pancreatic cancer recapitulate in vivo tumour biology
title_fullStr Bioengineered 3D models of human pancreatic cancer recapitulate in vivo tumour biology
title_full_unstemmed Bioengineered 3D models of human pancreatic cancer recapitulate in vivo tumour biology
title_sort bioengineered 3d models of human pancreatic cancer recapitulate in vivo tumour biology
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/aa4d680a8e804181b1c4842a522ec5d8
work_keys_str_mv AT davidosunadelapena bioengineered3dmodelsofhumanpancreaticcancerrecapitulateinvivotumourbiology
AT saramariadavidtrabulo bioengineered3dmodelsofhumanpancreaticcancerrecapitulateinvivotumourbiology
AT estellecollin bioengineered3dmodelsofhumanpancreaticcancerrecapitulateinvivotumourbiology
AT yingliu bioengineered3dmodelsofhumanpancreaticcancerrecapitulateinvivotumourbiology
AT shreyasharma bioengineered3dmodelsofhumanpancreaticcancerrecapitulateinvivotumourbiology
AT marianthitatari bioengineered3dmodelsofhumanpancreaticcancerrecapitulateinvivotumourbiology
AT dianabehrens bioengineered3dmodelsofhumanpancreaticcancerrecapitulateinvivotumourbiology
AT merterkan bioengineered3dmodelsofhumanpancreaticcancerrecapitulateinvivotumourbiology
AT ritatlawlor bioengineered3dmodelsofhumanpancreaticcancerrecapitulateinvivotumourbiology
AT aldoscarpa bioengineered3dmodelsofhumanpancreaticcancerrecapitulateinvivotumourbiology
AT christopherheeschen bioengineered3dmodelsofhumanpancreaticcancerrecapitulateinvivotumourbiology
AT alvaromata bioengineered3dmodelsofhumanpancreaticcancerrecapitulateinvivotumourbiology
AT danielaloessner bioengineered3dmodelsofhumanpancreaticcancerrecapitulateinvivotumourbiology
_version_ 1718377642727571456

Ejemplares similares