Orosomucoid, a new biomarker in the association between obesity and periodontitis.

Epidemiological data indicate an association between periodontitis and obesity. The biological mechanisms of this relationship remain unclear. A cross-sectional study was conducted to evaluate the relationship between periodontitis and the common systemic inflammatory markers in 32 morbidly obese pa...

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Autores principales:	Hélène Rangé, Christine Poitou, Adrien Boillot, Cécile Ciangura, Sandrine Katsahian, Jean-Marc Lacorte, Sébastien Czernichow, Olivier Meilhac, Philippe Bouchard, Catherine Chaussain
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/aa4df6716fad433d91b22ced3af4d007
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spelling	oai:doaj.org-article:aa4df6716fad433d91b22ced3af4d0072021-11-18T07:53:00ZOrosomucoid, a new biomarker in the association between obesity and periodontitis.1932-620310.1371/journal.pone.0057645https://doaj.org/article/aa4df6716fad433d91b22ced3af4d0072013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23526947/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Epidemiological data indicate an association between periodontitis and obesity. The biological mechanisms of this relationship remain unclear. A cross-sectional study was conducted to evaluate the relationship between periodontitis and the common systemic inflammatory markers in 32 morbidly obese patients recruited in a Clinical Nutrition department. Periodontal condition was evaluated using pocket depth (PD) measurement, a classical clinical marker of ongoing periodontitis. Major periodontal risk factors were recorded (age, gender, diabetes and smoking status), as well as plasma levels of inflammatory markers (CRP, orosomucoid, IL-6) and adipokines (adiponectin, leptin). All patients included in the sample exhibited evidence of periodontitis, 16 of whom were diagnosed as having severe disease. Adjusted logistic regression analysis indicated that the severity of periodontitis was associated with the plasma level of orosomucoid (p<0.04) after adjustment for age, gender and smoking. Our study thus suggests that the severity of periodontitis, in morbidly obese patients, is associated with the increase of orosomucoid levels.Hélène RangéChristine PoitouAdrien BoillotCécile CianguraSandrine KatsahianJean-Marc LacorteSébastien CzernichowOlivier MeilhacPhilippe BouchardCatherine ChaussainPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 3, p e57645 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hélène Rangé Christine Poitou Adrien Boillot Cécile Ciangura Sandrine Katsahian Jean-Marc Lacorte Sébastien Czernichow Olivier Meilhac Philippe Bouchard Catherine Chaussain Orosomucoid, a new biomarker in the association between obesity and periodontitis.
description	Epidemiological data indicate an association between periodontitis and obesity. The biological mechanisms of this relationship remain unclear. A cross-sectional study was conducted to evaluate the relationship between periodontitis and the common systemic inflammatory markers in 32 morbidly obese patients recruited in a Clinical Nutrition department. Periodontal condition was evaluated using pocket depth (PD) measurement, a classical clinical marker of ongoing periodontitis. Major periodontal risk factors were recorded (age, gender, diabetes and smoking status), as well as plasma levels of inflammatory markers (CRP, orosomucoid, IL-6) and adipokines (adiponectin, leptin). All patients included in the sample exhibited evidence of periodontitis, 16 of whom were diagnosed as having severe disease. Adjusted logistic regression analysis indicated that the severity of periodontitis was associated with the plasma level of orosomucoid (p<0.04) after adjustment for age, gender and smoking. Our study thus suggests that the severity of periodontitis, in morbidly obese patients, is associated with the increase of orosomucoid levels.
format	article
author	Hélène Rangé Christine Poitou Adrien Boillot Cécile Ciangura Sandrine Katsahian Jean-Marc Lacorte Sébastien Czernichow Olivier Meilhac Philippe Bouchard Catherine Chaussain
author_facet	Hélène Rangé Christine Poitou Adrien Boillot Cécile Ciangura Sandrine Katsahian Jean-Marc Lacorte Sébastien Czernichow Olivier Meilhac Philippe Bouchard Catherine Chaussain
author_sort	Hélène Rangé
title	Orosomucoid, a new biomarker in the association between obesity and periodontitis.
title_short	Orosomucoid, a new biomarker in the association between obesity and periodontitis.
title_full	Orosomucoid, a new biomarker in the association between obesity and periodontitis.
title_fullStr	Orosomucoid, a new biomarker in the association between obesity and periodontitis.
title_full_unstemmed	Orosomucoid, a new biomarker in the association between obesity and periodontitis.
title_sort	orosomucoid, a new biomarker in the association between obesity and periodontitis.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/aa4df6716fad433d91b22ced3af4d007
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Orosomucoid, a new biomarker in the association between obesity and periodontitis.

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