p190-B RhoGAP and intracellular cytokine signals balance hematopoietic stem and progenitor cell self-renewal and differentiation
The success of hematopoietic stem cell (HSC) transplantation relies on understanding what regulates the fate decision to self-renew. Here, the authors show using bothin vitro assays and in vivotransplantation that loss of the RhoGAP p190-B enhances self-renewal by inhibiting TGFβ/p38 signalling.
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Nature Portfolio
2017
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oai:doaj.org-article:aa4e1e51138e4312ba30120be3566b6b2021-12-02T17:06:29Zp190-B RhoGAP and intracellular cytokine signals balance hematopoietic stem and progenitor cell self-renewal and differentiation10.1038/ncomms143822041-1723https://doaj.org/article/aa4e1e51138e4312ba30120be3566b6b2017-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms14382https://doaj.org/toc/2041-1723The success of hematopoietic stem cell (HSC) transplantation relies on understanding what regulates the fate decision to self-renew. Here, the authors show using bothin vitro assays and in vivotransplantation that loss of the RhoGAP p190-B enhances self-renewal by inhibiting TGFβ/p38 signalling.Ashwini HingeJuying XuJose JavierEucabeth MoseSachin KumarReuben KapurEdward F. SrourPunam MalikBruce J. AronowMarie-Dominique FilippiNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017) |
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Science Q Ashwini Hinge Juying Xu Jose Javier Eucabeth Mose Sachin Kumar Reuben Kapur Edward F. Srour Punam Malik Bruce J. Aronow Marie-Dominique Filippi p190-B RhoGAP and intracellular cytokine signals balance hematopoietic stem and progenitor cell self-renewal and differentiation |
description |
The success of hematopoietic stem cell (HSC) transplantation relies on understanding what regulates the fate decision to self-renew. Here, the authors show using bothin vitro assays and in vivotransplantation that loss of the RhoGAP p190-B enhances self-renewal by inhibiting TGFβ/p38 signalling. |
format |
article |
author |
Ashwini Hinge Juying Xu Jose Javier Eucabeth Mose Sachin Kumar Reuben Kapur Edward F. Srour Punam Malik Bruce J. Aronow Marie-Dominique Filippi |
author_facet |
Ashwini Hinge Juying Xu Jose Javier Eucabeth Mose Sachin Kumar Reuben Kapur Edward F. Srour Punam Malik Bruce J. Aronow Marie-Dominique Filippi |
author_sort |
Ashwini Hinge |
title |
p190-B RhoGAP and intracellular cytokine signals balance hematopoietic stem and progenitor cell self-renewal and differentiation |
title_short |
p190-B RhoGAP and intracellular cytokine signals balance hematopoietic stem and progenitor cell self-renewal and differentiation |
title_full |
p190-B RhoGAP and intracellular cytokine signals balance hematopoietic stem and progenitor cell self-renewal and differentiation |
title_fullStr |
p190-B RhoGAP and intracellular cytokine signals balance hematopoietic stem and progenitor cell self-renewal and differentiation |
title_full_unstemmed |
p190-B RhoGAP and intracellular cytokine signals balance hematopoietic stem and progenitor cell self-renewal and differentiation |
title_sort |
p190-b rhogap and intracellular cytokine signals balance hematopoietic stem and progenitor cell self-renewal and differentiation |
publisher |
Nature Portfolio |
publishDate |
2017 |
url |
https://doaj.org/article/aa4e1e51138e4312ba30120be3566b6b |
work_keys_str_mv |
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