p190-B RhoGAP and intracellular cytokine signals balance hematopoietic stem and progenitor cell self-renewal and differentiation

The success of hematopoietic stem cell (HSC) transplantation relies on understanding what regulates the fate decision to self-renew. Here, the authors show using bothin vitro assays and in vivotransplantation that loss of the RhoGAP p190-B enhances self-renewal by inhibiting TGFβ/p38 signalling.

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Autores principales: Ashwini Hinge, Juying Xu, Jose Javier, Eucabeth Mose, Sachin Kumar, Reuben Kapur, Edward F. Srour, Punam Malik, Bruce J. Aronow, Marie-Dominique Filippi
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Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/aa4e1e51138e4312ba30120be3566b6b
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spelling oai:doaj.org-article:aa4e1e51138e4312ba30120be3566b6b2021-12-02T17:06:29Zp190-B RhoGAP and intracellular cytokine signals balance hematopoietic stem and progenitor cell self-renewal and differentiation10.1038/ncomms143822041-1723https://doaj.org/article/aa4e1e51138e4312ba30120be3566b6b2017-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms14382https://doaj.org/toc/2041-1723The success of hematopoietic stem cell (HSC) transplantation relies on understanding what regulates the fate decision to self-renew. Here, the authors show using bothin vitro assays and in vivotransplantation that loss of the RhoGAP p190-B enhances self-renewal by inhibiting TGFβ/p38 signalling.Ashwini HingeJuying XuJose JavierEucabeth MoseSachin KumarReuben KapurEdward F. SrourPunam MalikBruce J. AronowMarie-Dominique FilippiNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Ashwini Hinge
Juying Xu
Jose Javier
Eucabeth Mose
Sachin Kumar
Reuben Kapur
Edward F. Srour
Punam Malik
Bruce J. Aronow
Marie-Dominique Filippi
p190-B RhoGAP and intracellular cytokine signals balance hematopoietic stem and progenitor cell self-renewal and differentiation
description The success of hematopoietic stem cell (HSC) transplantation relies on understanding what regulates the fate decision to self-renew. Here, the authors show using bothin vitro assays and in vivotransplantation that loss of the RhoGAP p190-B enhances self-renewal by inhibiting TGFβ/p38 signalling.
format article
author Ashwini Hinge
Juying Xu
Jose Javier
Eucabeth Mose
Sachin Kumar
Reuben Kapur
Edward F. Srour
Punam Malik
Bruce J. Aronow
Marie-Dominique Filippi
author_facet Ashwini Hinge
Juying Xu
Jose Javier
Eucabeth Mose
Sachin Kumar
Reuben Kapur
Edward F. Srour
Punam Malik
Bruce J. Aronow
Marie-Dominique Filippi
author_sort Ashwini Hinge
title p190-B RhoGAP and intracellular cytokine signals balance hematopoietic stem and progenitor cell self-renewal and differentiation
title_short p190-B RhoGAP and intracellular cytokine signals balance hematopoietic stem and progenitor cell self-renewal and differentiation
title_full p190-B RhoGAP and intracellular cytokine signals balance hematopoietic stem and progenitor cell self-renewal and differentiation
title_fullStr p190-B RhoGAP and intracellular cytokine signals balance hematopoietic stem and progenitor cell self-renewal and differentiation
title_full_unstemmed p190-B RhoGAP and intracellular cytokine signals balance hematopoietic stem and progenitor cell self-renewal and differentiation
title_sort p190-b rhogap and intracellular cytokine signals balance hematopoietic stem and progenitor cell self-renewal and differentiation
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/aa4e1e51138e4312ba30120be3566b6b
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