<i>Campylobacter</i> Biofilms: Potential of Natural Compounds to Disrupt <i>Campylobacter jejuni</i> Transmission
Microbial biofilms occur naturally in many environmental niches and can be a significant reservoir of infectious microbes in zoonotically transmitted diseases such as that caused by <i>Campylobacter jejuni</i>, the leading cause of acute human bacterial gastroenteritis world-wide. The gr...
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oai:doaj.org-article:aa4ec3e957834838870fe883614bcc142021-11-25T17:53:53Z<i>Campylobacter</i> Biofilms: Potential of Natural Compounds to Disrupt <i>Campylobacter jejuni</i> Transmission10.3390/ijms2222121591422-00671661-6596https://doaj.org/article/aa4ec3e957834838870fe883614bcc142021-11-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/22/12159https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Microbial biofilms occur naturally in many environmental niches and can be a significant reservoir of infectious microbes in zoonotically transmitted diseases such as that caused by <i>Campylobacter jejuni</i>, the leading cause of acute human bacterial gastroenteritis world-wide. The greatest challenge in reducing the disease caused by this organism is reducing transmission of <i>C. jejuni</i> to humans from poultry via the food chain. Biofilms enhance the stress tolerance and antimicrobial resistance of the microorganisms they harbor and are considered to play a crucial role for <i>Campylobacter</i> spp. survival and transmission to humans. Unconventional approaches to control biofilms and to improve the efficacy of currently used antibiotics are urgently needed. This review summarizes the use plant- and microorganism-derived antimicrobial and antibiofilm compounds such as essential oils, antimicrobial peptides (AMPs), polyphenolic extracts, algae extracts, probiotic-derived factors, <span style="font-variant: small-caps;">d</span>-amino acids (DAs) and glycolipid biosurfactants with potential to control biofilms formed by <i>Campylobacter</i>, and the suggested mechanisms of their action. Further investigation and use of such natural compounds could improve preventative and remedial strategies aimed to limit the transmission of campylobacters and other human pathogens via the food chain.Bassam A. ElgamoudiVictoria KorolikMDPI AGarticle<i>Campylobacter</i>biofilmnatural compoundsantibiofilmBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 12159, p 12159 (2021) |
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DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
<i>Campylobacter</i> biofilm natural compounds antibiofilm Biology (General) QH301-705.5 Chemistry QD1-999 |
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<i>Campylobacter</i> biofilm natural compounds antibiofilm Biology (General) QH301-705.5 Chemistry QD1-999 Bassam A. Elgamoudi Victoria Korolik <i>Campylobacter</i> Biofilms: Potential of Natural Compounds to Disrupt <i>Campylobacter jejuni</i> Transmission |
| description |
Microbial biofilms occur naturally in many environmental niches and can be a significant reservoir of infectious microbes in zoonotically transmitted diseases such as that caused by <i>Campylobacter jejuni</i>, the leading cause of acute human bacterial gastroenteritis world-wide. The greatest challenge in reducing the disease caused by this organism is reducing transmission of <i>C. jejuni</i> to humans from poultry via the food chain. Biofilms enhance the stress tolerance and antimicrobial resistance of the microorganisms they harbor and are considered to play a crucial role for <i>Campylobacter</i> spp. survival and transmission to humans. Unconventional approaches to control biofilms and to improve the efficacy of currently used antibiotics are urgently needed. This review summarizes the use plant- and microorganism-derived antimicrobial and antibiofilm compounds such as essential oils, antimicrobial peptides (AMPs), polyphenolic extracts, algae extracts, probiotic-derived factors, <span style="font-variant: small-caps;">d</span>-amino acids (DAs) and glycolipid biosurfactants with potential to control biofilms formed by <i>Campylobacter</i>, and the suggested mechanisms of their action. Further investigation and use of such natural compounds could improve preventative and remedial strategies aimed to limit the transmission of campylobacters and other human pathogens via the food chain. |
| format |
article |
| author |
Bassam A. Elgamoudi Victoria Korolik |
| author_facet |
Bassam A. Elgamoudi Victoria Korolik |
| author_sort |
Bassam A. Elgamoudi |
| title |
<i>Campylobacter</i> Biofilms: Potential of Natural Compounds to Disrupt <i>Campylobacter jejuni</i> Transmission |
| title_short |
<i>Campylobacter</i> Biofilms: Potential of Natural Compounds to Disrupt <i>Campylobacter jejuni</i> Transmission |
| title_full |
<i>Campylobacter</i> Biofilms: Potential of Natural Compounds to Disrupt <i>Campylobacter jejuni</i> Transmission |
| title_fullStr |
<i>Campylobacter</i> Biofilms: Potential of Natural Compounds to Disrupt <i>Campylobacter jejuni</i> Transmission |
| title_full_unstemmed |
<i>Campylobacter</i> Biofilms: Potential of Natural Compounds to Disrupt <i>Campylobacter jejuni</i> Transmission |
| title_sort |
<i>campylobacter</i> biofilms: potential of natural compounds to disrupt <i>campylobacter jejuni</i> transmission |
| publisher |
MDPI AG |
| publishDate |
2021 |
| url |
https://doaj.org/article/aa4ec3e957834838870fe883614bcc14 |
| work_keys_str_mv |
AT bassamaelgamoudi icampylobacteribiofilmspotentialofnaturalcompoundstodisrupticampylobacterjejuniitransmission AT victoriakorolik icampylobacteribiofilmspotentialofnaturalcompoundstodisrupticampylobacterjejuniitransmission |
| _version_ |
1718411879669301248 |