A redox-mediated Kemp eliminase

The majority of enzymatic Kemp elimination reactions proceed via a well-established acid-base mechanism. Here, the authors show that cytochrome P450 is able to metabolize the leflunomide drug via a redox Kemp elimination, offering new insights into enzyme catalysis.

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Detalles Bibliográficos
Autores principales:	Aitao Li, Binju Wang, Adriana Ilie, Kshatresh D. Dubey, Gert Bange, Ivan V. Korendovych, Sason Shaik, Manfred T. Reetz
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/aa51e79cc994447a82719af128acff74
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spelling	oai:doaj.org-article:aa51e79cc994447a82719af128acff742021-12-02T14:41:07ZA redox-mediated Kemp eliminase10.1038/ncomms148762041-1723https://doaj.org/article/aa51e79cc994447a82719af128acff742017-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms14876https://doaj.org/toc/2041-1723The majority of enzymatic Kemp elimination reactions proceed via a well-established acid-base mechanism. Here, the authors show that cytochrome P450 is able to metabolize the leflunomide drug via a redox Kemp elimination, offering new insights into enzyme catalysis.Aitao LiBinju WangAdriana IlieKshatresh D. DubeyGert BangeIvan V. KorendovychSason ShaikManfred T. ReetzNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Aitao Li Binju Wang Adriana Ilie Kshatresh D. Dubey Gert Bange Ivan V. Korendovych Sason Shaik Manfred T. Reetz A redox-mediated Kemp eliminase
description	The majority of enzymatic Kemp elimination reactions proceed via a well-established acid-base mechanism. Here, the authors show that cytochrome P450 is able to metabolize the leflunomide drug via a redox Kemp elimination, offering new insights into enzyme catalysis.
format	article
author	Aitao Li Binju Wang Adriana Ilie Kshatresh D. Dubey Gert Bange Ivan V. Korendovych Sason Shaik Manfred T. Reetz
author_facet	Aitao Li Binju Wang Adriana Ilie Kshatresh D. Dubey Gert Bange Ivan V. Korendovych Sason Shaik Manfred T. Reetz
author_sort	Aitao Li
title	A redox-mediated Kemp eliminase
title_short	A redox-mediated Kemp eliminase
title_full	A redox-mediated Kemp eliminase
title_fullStr	A redox-mediated Kemp eliminase
title_full_unstemmed	A redox-mediated Kemp eliminase
title_sort	redox-mediated kemp eliminase
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/aa51e79cc994447a82719af128acff74
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A redox-mediated Kemp eliminase

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