Spherulitic copper–copper oxide nanostructure-based highly sensitive nonenzymatic glucose sensor

Spherulitic copper–copper oxide nanostructure-based highly sensitive nonenzymatic glucose sensor

Gautam Das, Thao Quynh Ngan Tran, Hyon Hee Yoon Department of Chemical and Biological Engineering, Gachon University, Seongnam, Republic of South Korea Abstract: In this work, three different spherulitic nanostructures Cu–CuOA, Cu–CuOB, and Cu–CuOC were synthesized in...

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Autores principales: Das G, Tran TQN, Yoon HH
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2015
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Medicine (General)
R5-920
Acceso en línea:https://doaj.org/article/aa52a4dfa58c485c99c109cf703e323e
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spelling oai:doaj.org-article:aa52a4dfa58c485c99c109cf703e323e2021-12-02T02:31:35ZSpherulitic copper–copper oxide nanostructure-based highly sensitive nonenzymatic glucose sensor1178-2013https://doaj.org/article/aa52a4dfa58c485c99c109cf703e323e2015-08-01T00:00:00Zhttp://www.dovepress.com/spherulitic-copperndashcopper-oxide-nanostructure-based-highly-sensiti-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Gautam Das, Thao Quynh Ngan Tran, Hyon Hee Yoon Department of Chemical and Biological Engineering, Gachon University, Seongnam, Republic of South Korea Abstract: In this work, three different spherulitic nanostructures Cu–CuOA, Cu–CuOB, and Cu–CuOC were synthesized in water-in-oil microemulsions by varying the surfactant concentration (30 mM, 40 mM, and 50 mM, respectively). The structural and morphological characteristics of the Cu–CuO nanostructures were investigated by ultraviolet–visible (UV–vis) spectroscopy, X-ray diffraction, scanning electron microscopy, and high-resolution transmission electron microscopy techniques. The synthesized nanostructures were deposited on multiwalled carbon nanotube (MWCNT)-modified indium tin oxide (ITO) electrodes to fabricate a nonenzymatic highly sensitive amperometric glucose sensor. The performance of the ITO/MWCNT/Cu–CuO electrodes in the glucose assay was examined by cyclic voltammetry and chronoamperometric studies. The sensitivity of the sensor varied with the spherulite type; Cu–CuOA, Cu–CuOB, and Cu–CuOC exhibited a sensitivity of 1,229, 3,012, and 3,642 µA mM-1·cm-2, respectively. Moreover, the linear range is dependent on the structure types: 0.023–0.29 mM, 0.07–0.8 mM, and 0.023–0.34 mM for Cu–CuOA, Cu–CuOB, and Cu–CuOC, respectively. An excellent response time of 3 seconds and a low detection limit of 2 µM were observed for Cu–CuOB at an applied potential of +0.34 V. In addition, this electrode was found to be resistant to interference by common interfering agents such as urea, cystamine, l-ascorbic acid, and creatinine. The high performance of the Cu–CuO spherulites with nanowire-to-nanorod outgrowths was primarily due to the high surface area and stability, and good three-dimensional structure. Furthermore, the ITO/MWCNT/Cu–CuOB electrode applied to real urine and serum sample showed satisfactory performance. Keywords: copper oxide, multiwalled carbon nanotubes, glucose sensor, cyclic voltammetryDas GTran TQNYoon HHDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2015, Iss Special Issue on diverse applications in Nano-Theranostics, Pp 165-178 (2015)
institution DOAJ
collection DOAJ
language EN
topic Medicine (General)
R5-920
spellingShingle Medicine (General)
R5-920
Das G
Tran TQN
Yoon HH
Spherulitic copper–copper oxide nanostructure-based highly sensitive nonenzymatic glucose sensor
description Gautam Das, Thao Quynh Ngan Tran, Hyon Hee Yoon Department of Chemical and Biological Engineering, Gachon University, Seongnam, Republic of South Korea Abstract: In this work, three different spherulitic nanostructures Cu–CuOA, Cu–CuOB, and Cu–CuOC were synthesized in water-in-oil microemulsions by varying the surfactant concentration (30 mM, 40 mM, and 50 mM, respectively). The structural and morphological characteristics of the Cu–CuO nanostructures were investigated by ultraviolet–visible (UV–vis) spectroscopy, X-ray diffraction, scanning electron microscopy, and high-resolution transmission electron microscopy techniques. The synthesized nanostructures were deposited on multiwalled carbon nanotube (MWCNT)-modified indium tin oxide (ITO) electrodes to fabricate a nonenzymatic highly sensitive amperometric glucose sensor. The performance of the ITO/MWCNT/Cu–CuO electrodes in the glucose assay was examined by cyclic voltammetry and chronoamperometric studies. The sensitivity of the sensor varied with the spherulite type; Cu–CuOA, Cu–CuOB, and Cu–CuOC exhibited a sensitivity of 1,229, 3,012, and 3,642 µA mM-1·cm-2, respectively. Moreover, the linear range is dependent on the structure types: 0.023–0.29 mM, 0.07–0.8 mM, and 0.023–0.34 mM for Cu–CuOA, Cu–CuOB, and Cu–CuOC, respectively. An excellent response time of 3 seconds and a low detection limit of 2 µM were observed for Cu–CuOB at an applied potential of +0.34 V. In addition, this electrode was found to be resistant to interference by common interfering agents such as urea, cystamine, l-ascorbic acid, and creatinine. The high performance of the Cu–CuO spherulites with nanowire-to-nanorod outgrowths was primarily due to the high surface area and stability, and good three-dimensional structure. Furthermore, the ITO/MWCNT/Cu–CuOB electrode applied to real urine and serum sample showed satisfactory performance. Keywords: copper oxide, multiwalled carbon nanotubes, glucose sensor, cyclic voltammetry
format article
author Das G
Tran TQN
Yoon HH
author_facet Das G
Tran TQN
Yoon HH
author_sort Das G
title Spherulitic copper–copper oxide nanostructure-based highly sensitive nonenzymatic glucose sensor
title_short Spherulitic copper–copper oxide nanostructure-based highly sensitive nonenzymatic glucose sensor
title_full Spherulitic copper–copper oxide nanostructure-based highly sensitive nonenzymatic glucose sensor
title_fullStr Spherulitic copper–copper oxide nanostructure-based highly sensitive nonenzymatic glucose sensor
title_full_unstemmed Spherulitic copper–copper oxide nanostructure-based highly sensitive nonenzymatic glucose sensor
title_sort spherulitic copper–copper oxide nanostructure-based highly sensitive nonenzymatic glucose sensor
publisher Dove Medical Press
publishDate 2015
url https://doaj.org/article/aa52a4dfa58c485c99c109cf703e323e
work_keys_str_mv AT dasg spheruliticcopperndashcopperoxidenanostructurebasedhighlysensitivenonenzymaticglucosesensor
AT trantqn spheruliticcopperndashcopperoxidenanostructurebasedhighlysensitivenonenzymaticglucosesensor
AT yoonhh spheruliticcopperndashcopperoxidenanostructurebasedhighlysensitivenonenzymaticglucosesensor
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