HuR regulates telomerase activity through TERC methylation

Mutations in the RNA component TERC can cause telomerase dysfunction but the underlying mechanisms are largely unknown. Here, the authors show that RNA-binding protein HuR regulates telomerase function by enhancing the methylation of TERC, which is impaired by several disease-relevant TERC mutations...

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Main Authors:	Hao Tang, Hu Wang, Xiaolei Cheng, Xiuqin Fan, Fan Yang, Mengmeng Zhang, Yanlian Chen, Yuyang Tian, Cihang Liu, Dongxing Shao, Bin Jiang, Yali Dou, Yusheng Cong, Junyue Xing, Xiaotian Zhang, Xia Yi, Zhou Songyang, Wenbin Ma, Yong Zhao, Xian Wang, Jinbiao Ma, Myriam Gorospe, Zhenyu Ju, Wengong Wang
Format:	article
Language:	EN
Published:	Nature Portfolio 2018
Subjects:	Science Q
Online Access:	https://doaj.org/article/aa53894e70b84c8cbe7b0f25337b8313
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spelling	oai:doaj.org-article:aa53894e70b84c8cbe7b0f25337b83132021-12-02T17:32:17ZHuR regulates telomerase activity through TERC methylation10.1038/s41467-018-04617-72041-1723https://doaj.org/article/aa53894e70b84c8cbe7b0f25337b83132018-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04617-7https://doaj.org/toc/2041-1723Mutations in the RNA component TERC can cause telomerase dysfunction but the underlying mechanisms are largely unknown. Here, the authors show that RNA-binding protein HuR regulates telomerase function by enhancing the methylation of TERC, which is impaired by several disease-relevant TERC mutations.Hao TangHu WangXiaolei ChengXiuqin FanFan YangMengmeng ZhangYanlian ChenYuyang TianCihang LiuDongxing ShaoBin JiangYali DouYusheng CongJunyue XingXiaotian ZhangXia YiZhou SongyangWenbin MaYong ZhaoXian WangJinbiao MaMyriam GorospeZhenyu JuWengong WangNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hao Tang Hu Wang Xiaolei Cheng Xiuqin Fan Fan Yang Mengmeng Zhang Yanlian Chen Yuyang Tian Cihang Liu Dongxing Shao Bin Jiang Yali Dou Yusheng Cong Junyue Xing Xiaotian Zhang Xia Yi Zhou Songyang Wenbin Ma Yong Zhao Xian Wang Jinbiao Ma Myriam Gorospe Zhenyu Ju Wengong Wang HuR regulates telomerase activity through TERC methylation
description	Mutations in the RNA component TERC can cause telomerase dysfunction but the underlying mechanisms are largely unknown. Here, the authors show that RNA-binding protein HuR regulates telomerase function by enhancing the methylation of TERC, which is impaired by several disease-relevant TERC mutations.
format	article
author	Hao Tang Hu Wang Xiaolei Cheng Xiuqin Fan Fan Yang Mengmeng Zhang Yanlian Chen Yuyang Tian Cihang Liu Dongxing Shao Bin Jiang Yali Dou Yusheng Cong Junyue Xing Xiaotian Zhang Xia Yi Zhou Songyang Wenbin Ma Yong Zhao Xian Wang Jinbiao Ma Myriam Gorospe Zhenyu Ju Wengong Wang
author_facet	Hao Tang Hu Wang Xiaolei Cheng Xiuqin Fan Fan Yang Mengmeng Zhang Yanlian Chen Yuyang Tian Cihang Liu Dongxing Shao Bin Jiang Yali Dou Yusheng Cong Junyue Xing Xiaotian Zhang Xia Yi Zhou Songyang Wenbin Ma Yong Zhao Xian Wang Jinbiao Ma Myriam Gorospe Zhenyu Ju Wengong Wang
author_sort	Hao Tang
title	HuR regulates telomerase activity through TERC methylation
title_short	HuR regulates telomerase activity through TERC methylation
title_full	HuR regulates telomerase activity through TERC methylation
title_fullStr	HuR regulates telomerase activity through TERC methylation
title_full_unstemmed	HuR regulates telomerase activity through TERC methylation
title_sort	hur regulates telomerase activity through terc methylation
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/aa53894e70b84c8cbe7b0f25337b8313
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_version_	1718380327133511680

HuR regulates telomerase activity through TERC methylation

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