In Fungal Intracellular Pathogenesis, Form Determines Fate

ABSTRACT For pathogenic microbes to survive ingestion by macrophages, they must subvert powerful microbicidal mechanisms within the phagolysosome. After ingestion, Candida albicans undergoes a morphological transition producing hyphae, while the surrounding phagosome exhibits a loss of phagosomal ac...

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Autores principales:	Robin C. May, Arturo Casadevall
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2018
Materias:	Candida Cryptococcus fungus macrophage phagosome Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/aa588ecb4cd54e66a47eadd9cd8e6b4d
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spelling	oai:doaj.org-article:aa588ecb4cd54e66a47eadd9cd8e6b4d2021-11-15T15:58:21ZIn Fungal Intracellular Pathogenesis, Form Determines Fate10.1128/mBio.02092-182150-7511https://doaj.org/article/aa588ecb4cd54e66a47eadd9cd8e6b4d2018-11-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.02092-18https://doaj.org/toc/2150-7511ABSTRACT For pathogenic microbes to survive ingestion by macrophages, they must subvert powerful microbicidal mechanisms within the phagolysosome. After ingestion, Candida albicans undergoes a morphological transition producing hyphae, while the surrounding phagosome exhibits a loss of phagosomal acidity. However, how these two events are related has remained enigmatic. Now Westman et al. (mBio 9:e01226-18, 2018, https://doi.org/10.1128/mBio.01226-18) report that phagosomal neutralization results from disruption of phagosomal membrane integrity by the enlarging hyphae, directly implicating the morphological transition in physical damage that promotes intracellular survival. The C. albicans intracellular strategy shows parallels with another fungal pathogen, Cryptococcus neoformans, where a morphological changed involving capsular enlargement intracellularly is associated with loss of membrane integrity and death of the host cell. These similarities among distantly related pathogenic fungi suggest that morphological transitions that are common in fungi directly affect the outcome of the fungal cell-macrophage interaction. For this class of organisms, form determines fate in the intracellular environment.Robin C. MayArturo CasadevallAmerican Society for MicrobiologyarticleCandidaCryptococcusfungusmacrophagephagosomeMicrobiologyQR1-502ENmBio, Vol 9, Iss 5 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Candida Cryptococcus fungus macrophage phagosome Microbiology QR1-502
spellingShingle	Candida Cryptococcus fungus macrophage phagosome Microbiology QR1-502 Robin C. May Arturo Casadevall In Fungal Intracellular Pathogenesis, Form Determines Fate
description	ABSTRACT For pathogenic microbes to survive ingestion by macrophages, they must subvert powerful microbicidal mechanisms within the phagolysosome. After ingestion, Candida albicans undergoes a morphological transition producing hyphae, while the surrounding phagosome exhibits a loss of phagosomal acidity. However, how these two events are related has remained enigmatic. Now Westman et al. (mBio 9:e01226-18, 2018, https://doi.org/10.1128/mBio.01226-18) report that phagosomal neutralization results from disruption of phagosomal membrane integrity by the enlarging hyphae, directly implicating the morphological transition in physical damage that promotes intracellular survival. The C. albicans intracellular strategy shows parallels with another fungal pathogen, Cryptococcus neoformans, where a morphological changed involving capsular enlargement intracellularly is associated with loss of membrane integrity and death of the host cell. These similarities among distantly related pathogenic fungi suggest that morphological transitions that are common in fungi directly affect the outcome of the fungal cell-macrophage interaction. For this class of organisms, form determines fate in the intracellular environment.
format	article
author	Robin C. May Arturo Casadevall
author_facet	Robin C. May Arturo Casadevall
author_sort	Robin C. May
title	In Fungal Intracellular Pathogenesis, Form Determines Fate
title_short	In Fungal Intracellular Pathogenesis, Form Determines Fate
title_full	In Fungal Intracellular Pathogenesis, Form Determines Fate
title_fullStr	In Fungal Intracellular Pathogenesis, Form Determines Fate
title_full_unstemmed	In Fungal Intracellular Pathogenesis, Form Determines Fate
title_sort	in fungal intracellular pathogenesis, form determines fate
publisher	American Society for Microbiology
publishDate	2018
url	https://doaj.org/article/aa588ecb4cd54e66a47eadd9cd8e6b4d
work_keys_str_mv	AT robincmay infungalintracellularpathogenesisformdeterminesfate AT arturocasadevall infungalintracellularpathogenesisformdeterminesfate
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In Fungal Intracellular Pathogenesis, Form Determines Fate

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