Difference in Cerebral Circulation Time between Subtypes of Moyamoya Disease and Moyamoya Syndrome

Difference in Cerebral Circulation Time between Subtypes of Moyamoya Disease and Moyamoya Syndrome

Abstract In this study, we evaluated the differences in hemodynamics between hemorrhagic and non-hemorrhagic moyamoya disease (MMD) and moyamoya syndrome (MMS) by measuring cerebral circulation time (CCT). This case-control study included 136 patients with MMD or MMS diagnosed between April 2015 and...

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Autores principales: Kaijiang Kang, Jingjing Lu, Dong Zhang, Youxiang Li, Dandan Wang, Peng Liu, Bohong Li, Yi Ju, Xingquan Zhao
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/aa59062f15384975af5e008b96d564fa
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spelling oai:doaj.org-article:aa59062f15384975af5e008b96d564fa2021-12-02T12:30:16ZDifference in Cerebral Circulation Time between Subtypes of Moyamoya Disease and Moyamoya Syndrome10.1038/s41598-017-02588-12045-2322https://doaj.org/article/aa59062f15384975af5e008b96d564fa2017-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-02588-1https://doaj.org/toc/2045-2322Abstract In this study, we evaluated the differences in hemodynamics between hemorrhagic and non-hemorrhagic moyamoya disease (MMD) and moyamoya syndrome (MMS) by measuring cerebral circulation time (CCT). This case-control study included 136 patients with MMD or MMS diagnosed between April 2015 and July 2016 at Beijing Tian Tan Hospital. Each hemisphere was analyzed separately. The difference in clinical, radiological characteristics and CCT between subtypes of MMD and MMS were analyzed statistically. The results showed that total CCT between hemorrhagic and non-hemorrhagic sides was not statistically different (16.55 s vs. 16.06 s, P = 0.562). The cerebral filling circulation time (CFCT) of hemorrhagic sides was significantly shorter than that of non-hemorrhagic sides (4.52 s vs. 5.41 s, P < 0.001), and the cerebral venous circulation time (CVCT) of hemorrhagic sides was significantly longer than that of non-hemorrhagic sides (12.02 s, vs. 10.64 s, P < 0.001). The ratio of CFCT to CVCT (F-V ratio) was inversely correlated with the possibility of hemorrhagic stroke. Therefore, we conclude that the rapid filling and poor venous drainage of cerebral circulation are likely risk factors of hemorrhagic stroke secondary to MMD or MMS. The F-V ratio can be used to identify individuals at high risk of hemorrhagic stroke.Kaijiang KangJingjing LuDong ZhangYouxiang LiDandan WangPeng LiuBohong LiYi JuXingquan ZhaoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Kaijiang Kang
Jingjing Lu
Dong Zhang
Youxiang Li
Dandan Wang
Peng Liu
Bohong Li
Yi Ju
Xingquan Zhao
Difference in Cerebral Circulation Time between Subtypes of Moyamoya Disease and Moyamoya Syndrome
description Abstract In this study, we evaluated the differences in hemodynamics between hemorrhagic and non-hemorrhagic moyamoya disease (MMD) and moyamoya syndrome (MMS) by measuring cerebral circulation time (CCT). This case-control study included 136 patients with MMD or MMS diagnosed between April 2015 and July 2016 at Beijing Tian Tan Hospital. Each hemisphere was analyzed separately. The difference in clinical, radiological characteristics and CCT between subtypes of MMD and MMS were analyzed statistically. The results showed that total CCT between hemorrhagic and non-hemorrhagic sides was not statistically different (16.55 s vs. 16.06 s, P = 0.562). The cerebral filling circulation time (CFCT) of hemorrhagic sides was significantly shorter than that of non-hemorrhagic sides (4.52 s vs. 5.41 s, P < 0.001), and the cerebral venous circulation time (CVCT) of hemorrhagic sides was significantly longer than that of non-hemorrhagic sides (12.02 s, vs. 10.64 s, P < 0.001). The ratio of CFCT to CVCT (F-V ratio) was inversely correlated with the possibility of hemorrhagic stroke. Therefore, we conclude that the rapid filling and poor venous drainage of cerebral circulation are likely risk factors of hemorrhagic stroke secondary to MMD or MMS. The F-V ratio can be used to identify individuals at high risk of hemorrhagic stroke.
format article
author Kaijiang Kang
Jingjing Lu
Dong Zhang
Youxiang Li
Dandan Wang
Peng Liu
Bohong Li
Yi Ju
Xingquan Zhao
author_facet Kaijiang Kang
Jingjing Lu
Dong Zhang
Youxiang Li
Dandan Wang
Peng Liu
Bohong Li
Yi Ju
Xingquan Zhao
author_sort Kaijiang Kang
title Difference in Cerebral Circulation Time between Subtypes of Moyamoya Disease and Moyamoya Syndrome
title_short Difference in Cerebral Circulation Time between Subtypes of Moyamoya Disease and Moyamoya Syndrome
title_full Difference in Cerebral Circulation Time between Subtypes of Moyamoya Disease and Moyamoya Syndrome
title_fullStr Difference in Cerebral Circulation Time between Subtypes of Moyamoya Disease and Moyamoya Syndrome
title_full_unstemmed Difference in Cerebral Circulation Time between Subtypes of Moyamoya Disease and Moyamoya Syndrome
title_sort difference in cerebral circulation time between subtypes of moyamoya disease and moyamoya syndrome
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/aa59062f15384975af5e008b96d564fa
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