Probable REM sleep behavior disorder is associated with longitudinal cortical thinning in Parkinson’s disease

Abstract REM sleep behavior disorder (RBD) has a poor prognostic implication in both motor and non-motor functions in Parkinson’s disease (PD) patients. However, to the best of our knowledge no study to date investigated the longitudinal cerebral changes underlying RBD symptoms in PD. We performed t...

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Autores principales:	Eun Jin Yoon, Oury Monchi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/aa5a20d21a094527a6827cc9719d7669
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spelling	oai:doaj.org-article:aa5a20d21a094527a6827cc9719d76692021-12-02T13:20:25ZProbable REM sleep behavior disorder is associated with longitudinal cortical thinning in Parkinson’s disease10.1038/s41531-021-00164-z2373-8057https://doaj.org/article/aa5a20d21a094527a6827cc9719d76692021-03-01T00:00:00Zhttps://doi.org/10.1038/s41531-021-00164-zhttps://doaj.org/toc/2373-8057Abstract REM sleep behavior disorder (RBD) has a poor prognostic implication in both motor and non-motor functions in Parkinson’s disease (PD) patients. However, to the best of our knowledge no study to date investigated the longitudinal cerebral changes underlying RBD symptoms in PD. We performed the longitudinal study to investigate the association between probable RBD and cortical and subcortical changes in early, de novo PD patients. We studied 78 participants from the Parkinson’s Progression Marker Initiative who underwent structural MRI at baseline and after 2 years. The presence of probable RBD (pRBD) was evaluated using the RBD screening questionnaire. We compared the cross-sectional and longitudinal cortical thickness and subcortical volume changes, between PD patients with and without pRBD. At baseline, we found bilateral inferior temporal cortex thinning in the PD-pRBD group compared with the PD-noRBD group. Longitudinally, the PD-pRBD group revealed a significant increase in the rate of thinning in the left insula compared with the PD-noRBD group, and the increased thinning correlated with decreased cognitive performance. In subcortical volume analyses, the presence of pRBD was linked with volume decrease over time in the left caudate nucleus, pallidum and amygdala. The volume changes in the left caudate nucleus revealed correlations with global cognition. These results support the idea that RBD is an important marker of rapid progression in PD motor and non-motor symptoms and suggest that the atrophy in the left insula and caudate nucleus might be the underlying neurobiological mechanisms of the poorer prognosis in PD patients with RBD.Eun Jin YoonOury MonchiNature PortfolioarticleNeurology. Diseases of the nervous systemRC346-429ENnpj Parkinson's Disease, Vol 7, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurology. Diseases of the nervous system RC346-429 Eun Jin Yoon Oury Monchi Probable REM sleep behavior disorder is associated with longitudinal cortical thinning in Parkinson’s disease
description	Abstract REM sleep behavior disorder (RBD) has a poor prognostic implication in both motor and non-motor functions in Parkinson’s disease (PD) patients. However, to the best of our knowledge no study to date investigated the longitudinal cerebral changes underlying RBD symptoms in PD. We performed the longitudinal study to investigate the association between probable RBD and cortical and subcortical changes in early, de novo PD patients. We studied 78 participants from the Parkinson’s Progression Marker Initiative who underwent structural MRI at baseline and after 2 years. The presence of probable RBD (pRBD) was evaluated using the RBD screening questionnaire. We compared the cross-sectional and longitudinal cortical thickness and subcortical volume changes, between PD patients with and without pRBD. At baseline, we found bilateral inferior temporal cortex thinning in the PD-pRBD group compared with the PD-noRBD group. Longitudinally, the PD-pRBD group revealed a significant increase in the rate of thinning in the left insula compared with the PD-noRBD group, and the increased thinning correlated with decreased cognitive performance. In subcortical volume analyses, the presence of pRBD was linked with volume decrease over time in the left caudate nucleus, pallidum and amygdala. The volume changes in the left caudate nucleus revealed correlations with global cognition. These results support the idea that RBD is an important marker of rapid progression in PD motor and non-motor symptoms and suggest that the atrophy in the left insula and caudate nucleus might be the underlying neurobiological mechanisms of the poorer prognosis in PD patients with RBD.
format	article
author	Eun Jin Yoon Oury Monchi
author_facet	Eun Jin Yoon Oury Monchi
author_sort	Eun Jin Yoon
title	Probable REM sleep behavior disorder is associated with longitudinal cortical thinning in Parkinson’s disease
title_short	Probable REM sleep behavior disorder is associated with longitudinal cortical thinning in Parkinson’s disease
title_full	Probable REM sleep behavior disorder is associated with longitudinal cortical thinning in Parkinson’s disease
title_fullStr	Probable REM sleep behavior disorder is associated with longitudinal cortical thinning in Parkinson’s disease
title_full_unstemmed	Probable REM sleep behavior disorder is associated with longitudinal cortical thinning in Parkinson’s disease
title_sort	probable rem sleep behavior disorder is associated with longitudinal cortical thinning in parkinson’s disease
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/aa5a20d21a094527a6827cc9719d7669
work_keys_str_mv	AT eunjinyoon probableremsleepbehaviordisorderisassociatedwithlongitudinalcorticalthinninginparkinsonsdisease AT ourymonchi probableremsleepbehaviordisorderisassociatedwithlongitudinalcorticalthinninginparkinsonsdisease
_version_	1718393232048521216

Probable REM sleep behavior disorder is associated with longitudinal cortical thinning in Parkinson’s disease

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