The mitochondrial DNA polymerase gamma degrades linear DNA fragments precluding the formation of deletions

Mitochondrial DNA fragments are rapidly degraded when double strand breaks occur. Here the authors reveal that the exonuclease activity of polymerase gamma is important for efficient degradation of these fragments and to avoid formation of large deletions.

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Autores principales:	Nadee Nissanka, Sandra R. Bacman, Melanie J. Plastini, Carlos T. Moraes
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/aa5ad2b48a7642f3848faf16ada6efe3
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spelling	oai:doaj.org-article:aa5ad2b48a7642f3848faf16ada6efe32021-12-02T17:31:46ZThe mitochondrial DNA polymerase gamma degrades linear DNA fragments precluding the formation of deletions10.1038/s41467-018-04895-12041-1723https://doaj.org/article/aa5ad2b48a7642f3848faf16ada6efe32018-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04895-1https://doaj.org/toc/2041-1723Mitochondrial DNA fragments are rapidly degraded when double strand breaks occur. Here the authors reveal that the exonuclease activity of polymerase gamma is important for efficient degradation of these fragments and to avoid formation of large deletions.Nadee NissankaSandra R. BacmanMelanie J. PlastiniCarlos T. MoraesNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Nadee Nissanka Sandra R. Bacman Melanie J. Plastini Carlos T. Moraes The mitochondrial DNA polymerase gamma degrades linear DNA fragments precluding the formation of deletions
description	Mitochondrial DNA fragments are rapidly degraded when double strand breaks occur. Here the authors reveal that the exonuclease activity of polymerase gamma is important for efficient degradation of these fragments and to avoid formation of large deletions.
format	article
author	Nadee Nissanka Sandra R. Bacman Melanie J. Plastini Carlos T. Moraes
author_facet	Nadee Nissanka Sandra R. Bacman Melanie J. Plastini Carlos T. Moraes
author_sort	Nadee Nissanka
title	The mitochondrial DNA polymerase gamma degrades linear DNA fragments precluding the formation of deletions
title_short	The mitochondrial DNA polymerase gamma degrades linear DNA fragments precluding the formation of deletions
title_full	The mitochondrial DNA polymerase gamma degrades linear DNA fragments precluding the formation of deletions
title_fullStr	The mitochondrial DNA polymerase gamma degrades linear DNA fragments precluding the formation of deletions
title_full_unstemmed	The mitochondrial DNA polymerase gamma degrades linear DNA fragments precluding the formation of deletions
title_sort	mitochondrial dna polymerase gamma degrades linear dna fragments precluding the formation of deletions
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/aa5ad2b48a7642f3848faf16ada6efe3
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The mitochondrial DNA polymerase gamma degrades linear DNA fragments precluding the formation of deletions

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