The mitochondrial DNA polymerase gamma degrades linear DNA fragments precluding the formation of deletions

Mitochondrial DNA fragments are rapidly degraded when double strand breaks occur. Here the authors reveal that the exonuclease activity of polymerase gamma is important for efficient degradation of these fragments and to avoid formation of large deletions.

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Autores principales: Nadee Nissanka, Sandra R. Bacman, Melanie J. Plastini, Carlos T. Moraes
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/aa5ad2b48a7642f3848faf16ada6efe3
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