Enucleated eyes after failed intra-arterial infusion of chemotherapy for unilateral retinoblastoma: histopathologic evaluation of vitreous seeding

Jonathan Kim1, Huy Do2, Peter Egbert11Department of Ophthalmology, Stanford Medical Center, Palo Alto, CA, USA; 2Department of Interventional Neuro-radiology, Stanford Medical Center, Stanford, CA, USAAbstract: Selective intra-arterial chemotherapy (IAC) has been adopted by many ocular oncology cent...

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Autores principales:	Kim JW, Do HM, Egbert P
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2011
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/aa5ea70bbfb64a3d9cf67265c6cf93e7
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spelling	oai:doaj.org-article:aa5ea70bbfb64a3d9cf67265c6cf93e72021-12-02T00:17:10ZEnucleated eyes after failed intra-arterial infusion of chemotherapy for unilateral retinoblastoma: histopathologic evaluation of vitreous seeding1177-54671177-5483https://doaj.org/article/aa5ea70bbfb64a3d9cf67265c6cf93e72011-11-01T00:00:00Zhttp://www.dovepress.com/enucleated-eyes-after-failed-intra-arterial-infusion-of-chemotherapy-f-a8728https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483Jonathan Kim1, Huy Do2, Peter Egbert11Department of Ophthalmology, Stanford Medical Center, Palo Alto, CA, USA; 2Department of Interventional Neuro-radiology, Stanford Medical Center, Stanford, CA, USAAbstract: Selective intra-arterial chemotherapy (IAC) has been adopted by many ocular oncology centers to treat advanced intraocular retinoblastoma. In this report, we describe two patients with unilateral intraocular retinoblastoma and persistent vitreous seeding, who were treated with IAC after failed systemic chemotherapy. Despite multiple sessions and increasing dosage of drug delivery, vitreous seeding in these cases failed to respond to IAC, and ultimately both eyes were enucleated for tumor control. Based on the histopathologic findings in these two cases, IAC appears to have limitations in treating persistent vitreous seeding in eyes which have failed systemic chemotherapy. Possible causes for failure of IAC to treat persistent vitreous seeding include poor vitreous penetration, inactive state of tumor seeds within the avascular vitreous cavity, and chemotherapeutic drug resistance.Keywords: chemotherapy, retinoblastoma, intra-arterial, failure, enucleation, eyeKim JWDo HMEgbert PDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2011, Iss default, Pp 1655-1658 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Kim JW Do HM Egbert P Enucleated eyes after failed intra-arterial infusion of chemotherapy for unilateral retinoblastoma: histopathologic evaluation of vitreous seeding
description	Jonathan Kim1, Huy Do2, Peter Egbert11Department of Ophthalmology, Stanford Medical Center, Palo Alto, CA, USA; 2Department of Interventional Neuro-radiology, Stanford Medical Center, Stanford, CA, USAAbstract: Selective intra-arterial chemotherapy (IAC) has been adopted by many ocular oncology centers to treat advanced intraocular retinoblastoma. In this report, we describe two patients with unilateral intraocular retinoblastoma and persistent vitreous seeding, who were treated with IAC after failed systemic chemotherapy. Despite multiple sessions and increasing dosage of drug delivery, vitreous seeding in these cases failed to respond to IAC, and ultimately both eyes were enucleated for tumor control. Based on the histopathologic findings in these two cases, IAC appears to have limitations in treating persistent vitreous seeding in eyes which have failed systemic chemotherapy. Possible causes for failure of IAC to treat persistent vitreous seeding include poor vitreous penetration, inactive state of tumor seeds within the avascular vitreous cavity, and chemotherapeutic drug resistance.Keywords: chemotherapy, retinoblastoma, intra-arterial, failure, enucleation, eye
format	article
author	Kim JW Do HM Egbert P
author_facet	Kim JW Do HM Egbert P
author_sort	Kim JW
title	Enucleated eyes after failed intra-arterial infusion of chemotherapy for unilateral retinoblastoma: histopathologic evaluation of vitreous seeding
title_short	Enucleated eyes after failed intra-arterial infusion of chemotherapy for unilateral retinoblastoma: histopathologic evaluation of vitreous seeding
title_full	Enucleated eyes after failed intra-arterial infusion of chemotherapy for unilateral retinoblastoma: histopathologic evaluation of vitreous seeding
title_fullStr	Enucleated eyes after failed intra-arterial infusion of chemotherapy for unilateral retinoblastoma: histopathologic evaluation of vitreous seeding
title_full_unstemmed	Enucleated eyes after failed intra-arterial infusion of chemotherapy for unilateral retinoblastoma: histopathologic evaluation of vitreous seeding
title_sort	enucleated eyes after failed intra-arterial infusion of chemotherapy for unilateral retinoblastoma: histopathologic evaluation of vitreous seeding
publisher	Dove Medical Press
publishDate	2011
url	https://doaj.org/article/aa5ea70bbfb64a3d9cf67265c6cf93e7
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Enucleated eyes after failed intra-arterial infusion of chemotherapy for unilateral retinoblastoma: histopathologic evaluation of vitreous seeding

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