Glibenclamide does not improve outcome following severe collagenase-induced intracerebral hemorrhage in rats.

Glibenclamide does not improve outcome following severe collagenase-induced intracerebral hemorrhage in rats.

Intracerebral hemorrhage (ICH) is a devastating insult with few effective treatments. Edema and raised intracranial pressure contribute to poor outcome after ICH. Glibenclamide blocks the sulfonylurea 1 transient receptor potential melastatin 4 (Sur1-Trpm4) channel implicated in edema formation. Whi...

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Autores principales: Tiffany F C Kung, Cassandra M Wilkinson, Christine A Dirks, Glen C Jickling, Frederick Colbourne
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2021
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/aa5fe3b5564147809f58863890600c95
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