Glibenclamide does not improve outcome following severe collagenase-induced intracerebral hemorrhage in rats.
Intracerebral hemorrhage (ICH) is a devastating insult with few effective treatments. Edema and raised intracranial pressure contribute to poor outcome after ICH. Glibenclamide blocks the sulfonylurea 1 transient receptor potential melastatin 4 (Sur1-Trpm4) channel implicated in edema formation. Whi...
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Auteurs principaux: | Tiffany F C Kung, Cassandra M Wilkinson, Christine A Dirks, Glen C Jickling, Frederick Colbourne |
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Format: | article |
Langue: | EN |
Publié: |
Public Library of Science (PLoS)
2021
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Accès en ligne: | https://doaj.org/article/aa5fe3b5564147809f58863890600c95 |
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