Clinicopathological Variables and Outcome in Chronic Myeloid Leukemia Associated With BCR-ABL1 Transcript Type and Body Weight: An Outcome of European LeukemiaNet Project
Objective It is debatable whether BCR-ABL1 transcript type has an impact on outcome of treatment of patients with CML, and it is not widely studied whether body weight influences response to treatment. In this study, we tried to find out if any of these factors has an impact on response to treatment...
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2021
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oai:doaj.org-article:aa6096a507c045d9acd9a0fc42e598642021-11-18T23:33:55ZClinicopathological Variables and Outcome in Chronic Myeloid Leukemia Associated With BCR-ABL1 Transcript Type and Body Weight: An Outcome of European LeukemiaNet Project1073-274810.1177/10732748211038429https://doaj.org/article/aa6096a507c045d9acd9a0fc42e598642021-08-01T00:00:00Zhttps://doi.org/10.1177/10732748211038429https://doaj.org/toc/1073-2748Objective It is debatable whether BCR-ABL1 transcript type has an impact on outcome of treatment of patients with CML, and it is not widely studied whether body weight influences response to treatment. In this study, we tried to find out if any of these factors has an impact on response to treatment and outcome. Methodology We conducted a retrospective analysis of the files of 79 patients being treated in our center for CML with known BCR-ABL1 breakpoints, and patients’ management and response assessment was done based on ELN 2013 guidelines. The analysis was performed based on two main groups, obese vs. normal BMI, and then based on BCR-ABL1 transcripts: e13a2 vs. e14a2. Cumulative incidence of MMR, CCyR, and DMR were estimated using the Kaplan–Meier survival curve method, and comparisons between groups were performed by the Log-rank/Gray test methods. Results/conclusion In the patient-cohort studied, there was no statistically significant difference in molecular response between patients with CML based on body weight or transcript type although patients in the obesity group achieved higher and faster MMR with no statistical significance.Mohammad A. J. Abdulla MDPrem Chandra PhDSusanna El Akiki PhDMahmood B. Aldapt MDSundus Sardar MBBSAmmar Chapra MBBSAbdulqadir J. Nashwan MSCClaudio Sorio MD, PhDLuisa Tomasello PhDChristian Boni PhDMohamed A. Yassin MBBS, CABM MSC, FACP MSCSAGE PublishingarticleNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancer Control, Vol 28 (2021) |
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DOAJ |
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EN |
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Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 |
| spellingShingle |
Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Mohammad A. J. Abdulla MD Prem Chandra PhD Susanna El Akiki PhD Mahmood B. Aldapt MD Sundus Sardar MBBS Ammar Chapra MBBS Abdulqadir J. Nashwan MSC Claudio Sorio MD, PhD Luisa Tomasello PhD Christian Boni PhD Mohamed A. Yassin MBBS, CABM MSC, FACP MSC Clinicopathological Variables and Outcome in Chronic Myeloid Leukemia Associated With BCR-ABL1 Transcript Type and Body Weight: An Outcome of European LeukemiaNet Project |
| description |
Objective It is debatable whether BCR-ABL1 transcript type has an impact on outcome of treatment of patients with CML, and it is not widely studied whether body weight influences response to treatment. In this study, we tried to find out if any of these factors has an impact on response to treatment and outcome. Methodology We conducted a retrospective analysis of the files of 79 patients being treated in our center for CML with known BCR-ABL1 breakpoints, and patients’ management and response assessment was done based on ELN 2013 guidelines. The analysis was performed based on two main groups, obese vs. normal BMI, and then based on BCR-ABL1 transcripts: e13a2 vs. e14a2. Cumulative incidence of MMR, CCyR, and DMR were estimated using the Kaplan–Meier survival curve method, and comparisons between groups were performed by the Log-rank/Gray test methods. Results/conclusion In the patient-cohort studied, there was no statistically significant difference in molecular response between patients with CML based on body weight or transcript type although patients in the obesity group achieved higher and faster MMR with no statistical significance. |
| format |
article |
| author |
Mohammad A. J. Abdulla MD Prem Chandra PhD Susanna El Akiki PhD Mahmood B. Aldapt MD Sundus Sardar MBBS Ammar Chapra MBBS Abdulqadir J. Nashwan MSC Claudio Sorio MD, PhD Luisa Tomasello PhD Christian Boni PhD Mohamed A. Yassin MBBS, CABM MSC, FACP MSC |
| author_facet |
Mohammad A. J. Abdulla MD Prem Chandra PhD Susanna El Akiki PhD Mahmood B. Aldapt MD Sundus Sardar MBBS Ammar Chapra MBBS Abdulqadir J. Nashwan MSC Claudio Sorio MD, PhD Luisa Tomasello PhD Christian Boni PhD Mohamed A. Yassin MBBS, CABM MSC, FACP MSC |
| author_sort |
Mohammad A. J. Abdulla MD |
| title |
Clinicopathological Variables and Outcome in Chronic Myeloid Leukemia Associated With BCR-ABL1 Transcript Type and Body Weight: An Outcome of European LeukemiaNet Project |
| title_short |
Clinicopathological Variables and Outcome in Chronic Myeloid Leukemia Associated With BCR-ABL1 Transcript Type and Body Weight: An Outcome of European LeukemiaNet Project |
| title_full |
Clinicopathological Variables and Outcome in Chronic Myeloid Leukemia Associated With BCR-ABL1 Transcript Type and Body Weight: An Outcome of European LeukemiaNet Project |
| title_fullStr |
Clinicopathological Variables and Outcome in Chronic Myeloid Leukemia Associated With BCR-ABL1 Transcript Type and Body Weight: An Outcome of European LeukemiaNet Project |
| title_full_unstemmed |
Clinicopathological Variables and Outcome in Chronic Myeloid Leukemia Associated With BCR-ABL1 Transcript Type and Body Weight: An Outcome of European LeukemiaNet Project |
| title_sort |
clinicopathological variables and outcome in chronic myeloid leukemia associated with bcr-abl1 transcript type and body weight: an outcome of european leukemianet project |
| publisher |
SAGE Publishing |
| publishDate |
2021 |
| url |
https://doaj.org/article/aa6096a507c045d9acd9a0fc42e59864 |
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