An association analysis between mitochondrial DNA A10398G polymorphism and temperament in Japanese young adults.

The mitochondrial (mt) DNA C5178A and A10398G polymorphisms have been reported to be associated with mental disorders such as bipolar disorder. However, the effects of these polymorphisms on temperament in healthy people are poorly understood. Evaluating healthy subjects can have the advantage of pr...

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Autores principales:	Kunihiro Kishida, Mihoko Tominaga, Kiminori Matsubara, Masanori Taguchi, Masanori Noguchi, Noriaki Tsunawake, Yoshihiro Shidoji
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2009
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/aa63e0a733e0437b8f7345a5add64ce9
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id	oai:doaj.org-article:aa63e0a733e0437b8f7345a5add64ce9
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spelling	oai:doaj.org-article:aa63e0a733e0437b8f7345a5add64ce92021-11-25T06:28:15ZAn association analysis between mitochondrial DNA A10398G polymorphism and temperament in Japanese young adults.1932-620310.1371/journal.pone.0007763https://doaj.org/article/aa63e0a733e0437b8f7345a5add64ce92009-11-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/19898620/?tool=EBIhttps://doaj.org/toc/1932-6203The mitochondrial (mt) DNA C5178A and A10398G polymorphisms have been reported to be associated with mental disorders such as bipolar disorder. However, the effects of these polymorphisms on temperament in healthy people are poorly understood. Evaluating healthy subjects can have the advantage of providing new strategies for maintaining psychological health and preventing mental illness. We examined the association between mtDNA polymorphisms and temperament in Japanese students. There was no significant difference in examined temperament when analysed by genotypes, 5178-10398 haplotypes, or sex. The subgroup analysis based on sex indicated that there was an interactive effect of the mtDNA A10398G polymorphism and sex on anxiety and obsession. This finding is preliminary and cannot exclude the possibility of false-positive due to small sample size (144 subjects) and multiple statistical testing. Further studies involving a larger sample size or other ethnic groups are necessary to confirm that mtDNA A10398G polymorphism can be a genetic factor for temperament.Kunihiro KishidaMihoko TominagaKiminori MatsubaraMasanori TaguchiMasanori NoguchiNoriaki TsunawakeYoshihiro ShidojiPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 4, Iss 11, p e7763 (2009)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kunihiro Kishida Mihoko Tominaga Kiminori Matsubara Masanori Taguchi Masanori Noguchi Noriaki Tsunawake Yoshihiro Shidoji An association analysis between mitochondrial DNA A10398G polymorphism and temperament in Japanese young adults.
description	The mitochondrial (mt) DNA C5178A and A10398G polymorphisms have been reported to be associated with mental disorders such as bipolar disorder. However, the effects of these polymorphisms on temperament in healthy people are poorly understood. Evaluating healthy subjects can have the advantage of providing new strategies for maintaining psychological health and preventing mental illness. We examined the association between mtDNA polymorphisms and temperament in Japanese students. There was no significant difference in examined temperament when analysed by genotypes, 5178-10398 haplotypes, or sex. The subgroup analysis based on sex indicated that there was an interactive effect of the mtDNA A10398G polymorphism and sex on anxiety and obsession. This finding is preliminary and cannot exclude the possibility of false-positive due to small sample size (144 subjects) and multiple statistical testing. Further studies involving a larger sample size or other ethnic groups are necessary to confirm that mtDNA A10398G polymorphism can be a genetic factor for temperament.
format	article
author	Kunihiro Kishida Mihoko Tominaga Kiminori Matsubara Masanori Taguchi Masanori Noguchi Noriaki Tsunawake Yoshihiro Shidoji
author_facet	Kunihiro Kishida Mihoko Tominaga Kiminori Matsubara Masanori Taguchi Masanori Noguchi Noriaki Tsunawake Yoshihiro Shidoji
author_sort	Kunihiro Kishida
title	An association analysis between mitochondrial DNA A10398G polymorphism and temperament in Japanese young adults.
title_short	An association analysis between mitochondrial DNA A10398G polymorphism and temperament in Japanese young adults.
title_full	An association analysis between mitochondrial DNA A10398G polymorphism and temperament in Japanese young adults.
title_fullStr	An association analysis between mitochondrial DNA A10398G polymorphism and temperament in Japanese young adults.
title_full_unstemmed	An association analysis between mitochondrial DNA A10398G polymorphism and temperament in Japanese young adults.
title_sort	association analysis between mitochondrial dna a10398g polymorphism and temperament in japanese young adults.
publisher	Public Library of Science (PLoS)
publishDate	2009
url	https://doaj.org/article/aa63e0a733e0437b8f7345a5add64ce9
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An association analysis between mitochondrial DNA A10398G polymorphism and temperament in Japanese young adults.

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