Enantiodivergence by minimal modification of an acyclic chiral secondary aminocatalyst

Enantiodivergent methods, which to access both enantiomers of the same compound, are of importance in drug synthesis. Here, the authors show that by simply changing a NiBu- to a NMe-group in readily available amine organocatalysts, high stereocontrol and broad scope are achieved in eight asymmetric...

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Autores principales:	Jun Dai, Zhuang Wang, Yuhua Deng, Lei Zhu, Fangzhi Peng, Yu Lan, Zhihui Shao
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/aa64014d1ebc414ba5b6bfcaf4d115fe
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spelling	oai:doaj.org-article:aa64014d1ebc414ba5b6bfcaf4d115fe2021-12-02T14:39:38ZEnantiodivergence by minimal modification of an acyclic chiral secondary aminocatalyst10.1038/s41467-019-13183-52041-1723https://doaj.org/article/aa64014d1ebc414ba5b6bfcaf4d115fe2019-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13183-5https://doaj.org/toc/2041-1723Enantiodivergent methods, which to access both enantiomers of the same compound, are of importance in drug synthesis. Here, the authors show that by simply changing a NiBu- to a NMe-group in readily available amine organocatalysts, high stereocontrol and broad scope are achieved in eight asymmetric reactions.Jun DaiZhuang WangYuhua DengLei ZhuFangzhi PengYu LanZhihui ShaoNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-8 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jun Dai Zhuang Wang Yuhua Deng Lei Zhu Fangzhi Peng Yu Lan Zhihui Shao Enantiodivergence by minimal modification of an acyclic chiral secondary aminocatalyst
description	Enantiodivergent methods, which to access both enantiomers of the same compound, are of importance in drug synthesis. Here, the authors show that by simply changing a NiBu- to a NMe-group in readily available amine organocatalysts, high stereocontrol and broad scope are achieved in eight asymmetric reactions.
format	article
author	Jun Dai Zhuang Wang Yuhua Deng Lei Zhu Fangzhi Peng Yu Lan Zhihui Shao
author_facet	Jun Dai Zhuang Wang Yuhua Deng Lei Zhu Fangzhi Peng Yu Lan Zhihui Shao
author_sort	Jun Dai
title	Enantiodivergence by minimal modification of an acyclic chiral secondary aminocatalyst
title_short	Enantiodivergence by minimal modification of an acyclic chiral secondary aminocatalyst
title_full	Enantiodivergence by minimal modification of an acyclic chiral secondary aminocatalyst
title_fullStr	Enantiodivergence by minimal modification of an acyclic chiral secondary aminocatalyst
title_full_unstemmed	Enantiodivergence by minimal modification of an acyclic chiral secondary aminocatalyst
title_sort	enantiodivergence by minimal modification of an acyclic chiral secondary aminocatalyst
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/aa64014d1ebc414ba5b6bfcaf4d115fe
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Enantiodivergence by minimal modification of an acyclic chiral secondary aminocatalyst

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